| Full name: mannosidase alpha class 2A member 1 | Alias Symbol: GOLIM7 | ||
| Type: protein-coding gene | Cytoband: 5q21.3 | ||
| Entrez ID: 4124 | HGNC ID: HGNC:6824 | Ensembl Gene: ENSG00000112893 | OMIM ID: 154582 |
| Drug and gene relationship at DGIdb | |||
Expression of MAN2A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAN2A1 | 4124 | 205105_at | 0.2327 | 0.7162 | |
| GSE20347 | MAN2A1 | 4124 | 205105_at | -0.4591 | 0.0537 | |
| GSE23400 | MAN2A1 | 4124 | 205105_at | 0.0329 | 0.7783 | |
| GSE26886 | MAN2A1 | 4124 | 226538_at | -0.5140 | 0.0149 | |
| GSE29001 | MAN2A1 | 4124 | 205105_at | -0.3047 | 0.4975 | |
| GSE38129 | MAN2A1 | 4124 | 205105_at | -0.2041 | 0.2878 | |
| GSE45670 | MAN2A1 | 4124 | 226538_at | 0.0777 | 0.6869 | |
| GSE53622 | MAN2A1 | 4124 | 21554 | 0.0008 | 0.9947 | |
| GSE53624 | MAN2A1 | 4124 | 21554 | -0.0948 | 0.1828 | |
| GSE63941 | MAN2A1 | 4124 | 226538_at | -1.5543 | 0.0168 | |
| GSE77861 | MAN2A1 | 4124 | 226538_at | -0.2978 | 0.6072 | |
| GSE97050 | MAN2A1 | 4124 | A_23_P360769 | -0.5535 | 0.5724 | |
| SRP007169 | MAN2A1 | 4124 | RNAseq | -0.2727 | 0.5219 | |
| SRP008496 | MAN2A1 | 4124 | RNAseq | 0.0645 | 0.8245 | |
| SRP064894 | MAN2A1 | 4124 | RNAseq | 0.3104 | 0.1518 | |
| SRP133303 | MAN2A1 | 4124 | RNAseq | 0.4726 | 0.0278 | |
| SRP159526 | MAN2A1 | 4124 | RNAseq | -0.4547 | 0.3536 | |
| SRP193095 | MAN2A1 | 4124 | RNAseq | -0.5876 | 0.0000 | |
| SRP219564 | MAN2A1 | 4124 | RNAseq | -0.0695 | 0.8255 | |
| TCGA | MAN2A1 | 4124 | RNAseq | -0.1510 | 0.0349 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MAN2A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAN2A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAN2A1 | 4124 | 1 | 13 | 16 | |
| GSE20123 | MAN2A1 | 4124 | 1 | 13 | 16 | |
| GSE43470 | MAN2A1 | 4124 | 3 | 8 | 32 | |
| GSE46452 | MAN2A1 | 4124 | 0 | 28 | 31 | |
| GSE47630 | MAN2A1 | 4124 | 0 | 21 | 19 | |
| GSE54993 | MAN2A1 | 4124 | 9 | 1 | 60 | |
| GSE54994 | MAN2A1 | 4124 | 1 | 17 | 35 | |
| GSE60625 | MAN2A1 | 4124 | 0 | 0 | 11 | |
| GSE74703 | MAN2A1 | 4124 | 2 | 6 | 28 | |
| GSE74704 | MAN2A1 | 4124 | 1 | 7 | 12 | |
| TCGA | MAN2A1 | 4124 | 2 | 41 | 53 |
Total number of gains: 20; Total number of losses: 155; Total Number of normals: 313.
Somatic mutations of MAN2A1:
Generating mutation plots.
Highly correlated genes for MAN2A1:
Showing top 20/380 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAN2A1 | AHCY | 0.687515 | 3 | 0 | 3 |
| MAN2A1 | PGM2 | 0.670981 | 3 | 0 | 3 |
| MAN2A1 | TRAPPC6B | 0.667152 | 3 | 0 | 3 |
| MAN2A1 | PHACTR4 | 0.66103 | 3 | 0 | 3 |
| MAN2A1 | GRPEL2 | 0.660298 | 3 | 0 | 3 |
| MAN2A1 | GLUD2 | 0.659698 | 3 | 0 | 3 |
| MAN2A1 | ZMIZ1 | 0.657335 | 3 | 0 | 3 |
| MAN2A1 | LPAR3 | 0.651587 | 3 | 0 | 3 |
| MAN2A1 | PJA2 | 0.651558 | 7 | 0 | 6 |
| MAN2A1 | MAP4K5 | 0.645829 | 3 | 0 | 3 |
| MAN2A1 | UGP2 | 0.645312 | 3 | 0 | 3 |
| MAN2A1 | EAF1 | 0.643883 | 5 | 0 | 5 |
| MAN2A1 | AK3 | 0.642667 | 3 | 0 | 3 |
| MAN2A1 | ACSL3 | 0.640158 | 3 | 0 | 3 |
| MAN2A1 | SUMF2 | 0.638538 | 3 | 0 | 3 |
| MAN2A1 | APPL2 | 0.6361 | 3 | 0 | 3 |
| MAN2A1 | SPTLC3 | 0.634745 | 3 | 0 | 3 |
| MAN2A1 | HOOK3 | 0.631496 | 3 | 0 | 3 |
| MAN2A1 | RSPRY1 | 0.631042 | 3 | 0 | 3 |
| MAN2A1 | HUS1 | 0.626672 | 3 | 0 | 3 |
For details and further investigation, click here
