| Full name: 2'-5'-oligoadenylate synthetase like | Alias Symbol: TRIP14|p59OASL|OASL1 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 8638 | HGNC ID: HGNC:8090 | Ensembl Gene: ENSG00000135114 | OMIM ID: 603281 |
| Drug and gene relationship at DGIdb | |||
Expression of OASL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OASL | 8638 | 210797_s_at | 0.9328 | 0.0702 | |
| GSE20347 | OASL | 8638 | 210797_s_at | 0.1738 | 0.0842 | |
| GSE23400 | OASL | 8638 | 205660_at | 0.3793 | 0.0054 | |
| GSE26886 | OASL | 8638 | 210797_s_at | 0.0029 | 0.9885 | |
| GSE29001 | OASL | 8638 | 205660_at | 1.1011 | 0.0007 | |
| GSE38129 | OASL | 8638 | 210797_s_at | 0.4344 | 0.0058 | |
| GSE45670 | OASL | 8638 | 205660_at | 2.4758 | 0.0000 | |
| GSE53622 | OASL | 8638 | 43688 | 1.5691 | 0.0000 | |
| GSE53624 | OASL | 8638 | 43688 | 1.7101 | 0.0000 | |
| GSE63941 | OASL | 8638 | 210797_s_at | 1.6885 | 0.2002 | |
| GSE77861 | OASL | 8638 | 210797_s_at | 0.3791 | 0.2537 | |
| GSE97050 | OASL | 8638 | A_23_P139786 | 0.9994 | 0.1646 | |
| SRP008496 | OASL | 8638 | RNAseq | 2.7855 | 0.0027 | |
| SRP064894 | OASL | 8638 | RNAseq | 2.5333 | 0.0000 | |
| SRP133303 | OASL | 8638 | RNAseq | 2.1356 | 0.0000 | |
| SRP193095 | OASL | 8638 | RNAseq | 0.3404 | 0.4349 | |
| TCGA | OASL | 8638 | RNAseq | 0.1799 | 0.3900 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by OASL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OASL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OASL | 8638 | 6 | 2 | 22 | |
| GSE20123 | OASL | 8638 | 6 | 2 | 22 | |
| GSE43470 | OASL | 8638 | 2 | 2 | 39 | |
| GSE46452 | OASL | 8638 | 9 | 1 | 49 | |
| GSE47630 | OASL | 8638 | 9 | 3 | 28 | |
| GSE54993 | OASL | 8638 | 0 | 5 | 65 | |
| GSE54994 | OASL | 8638 | 6 | 7 | 40 | |
| GSE60625 | OASL | 8638 | 0 | 0 | 11 | |
| GSE74703 | OASL | 8638 | 2 | 1 | 33 | |
| GSE74704 | OASL | 8638 | 3 | 2 | 15 | |
| TCGA | OASL | 8638 | 21 | 11 | 64 |
Total number of gains: 64; Total number of losses: 36; Total Number of normals: 388.
Somatic mutations of OASL:
Generating mutation plots.
Highly correlated genes for OASL:
Showing top 20/404 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OASL | AGTRAP | 0.740636 | 3 | 0 | 3 |
| OASL | USP41 | 0.694346 | 3 | 0 | 3 |
| OASL | OAS3 | 0.69339 | 12 | 0 | 10 |
| OASL | DDX60 | 0.668412 | 12 | 0 | 11 |
| OASL | RSAD2 | 0.66558 | 12 | 0 | 10 |
| OASL | IFIT3 | 0.665292 | 13 | 0 | 10 |
| OASL | OAS2 | 0.662824 | 12 | 0 | 10 |
| OASL | DDX60L | 0.660702 | 5 | 0 | 4 |
| OASL | ACVR1C | 0.66034 | 3 | 0 | 3 |
| OASL | IFI44 | 0.656502 | 13 | 0 | 11 |
| OASL | MX2 | 0.655864 | 8 | 0 | 6 |
| OASL | ZNFX1 | 0.651937 | 7 | 0 | 7 |
| OASL | WDR66 | 0.651936 | 6 | 0 | 5 |
| OASL | EPSTI1 | 0.643603 | 7 | 0 | 6 |
| OASL | HELZ2 | 0.641385 | 6 | 0 | 4 |
| OASL | ISG15 | 0.641345 | 13 | 0 | 9 |
| OASL | TTYH3 | 0.641299 | 5 | 0 | 5 |
| OASL | ZBP1 | 0.641251 | 7 | 0 | 6 |
| OASL | IL4I1 | 0.64011 | 6 | 0 | 5 |
| OASL | KAAG1 | 0.636871 | 4 | 0 | 4 |
For details and further investigation, click here
