| Full name: occludin | Alias Symbol: PPP1R115 | ||
| Type: protein-coding gene | Cytoband: 5q13.2 | ||
| Entrez ID: 100506658 | HGNC ID: HGNC:8104 | Ensembl Gene: ENSG00000197822 | OMIM ID: 602876 |
| Drug and gene relationship at DGIdb | |||
OCLN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of OCLN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OCLN | 100506658 | 227492_at | -1.3710 | 0.2495 | |
| GSE20347 | OCLN | 100506658 | 209925_at | -1.3646 | 0.0000 | |
| GSE23400 | OCLN | 100506658 | 209925_at | -0.4426 | 0.0000 | |
| GSE26886 | OCLN | 100506658 | 227492_at | -2.5578 | 0.0000 | |
| GSE29001 | OCLN | 100506658 | 209925_at | -0.9303 | 0.0074 | |
| GSE38129 | OCLN | 100506658 | 209925_at | -0.9066 | 0.0002 | |
| GSE45670 | OCLN | 100506658 | 227492_at | -0.7749 | 0.0083 | |
| GSE53622 | OCLN | 100506658 | 59296 | -2.0444 | 0.0000 | |
| GSE53624 | OCLN | 100506658 | 59296 | -2.3992 | 0.0000 | |
| GSE63941 | OCLN | 100506658 | 227492_at | 3.8069 | 0.0006 | |
| GSE77861 | OCLN | 100506658 | 227492_at | -1.0577 | 0.0077 | |
| GSE97050 | OCLN | 100506658 | A_24_P102053 | -0.2935 | 0.7725 | |
| SRP007169 | OCLN | 100506658 | RNAseq | -0.8950 | 0.0223 | |
| SRP008496 | OCLN | 100506658 | RNAseq | -1.6247 | 0.0001 | |
| SRP064894 | OCLN | 100506658 | RNAseq | -1.7477 | 0.0000 | |
| SRP133303 | OCLN | 100506658 | RNAseq | -1.5416 | 0.0001 | |
| SRP159526 | OCLN | 100506658 | RNAseq | -2.4032 | 0.0000 | |
| SRP193095 | OCLN | 100506658 | RNAseq | -1.7181 | 0.0000 | |
| SRP219564 | OCLN | 100506658 | RNAseq | -2.5457 | 0.0003 | |
| TCGA | OCLN | 100506658 | RNAseq | -0.6115 | 0.0019 |
Upregulated datasets: 1; Downregulated datasets: 11.
Survival by OCLN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OCLN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OCLN | 100506658 | 1 | 13 | 16 | |
| GSE20123 | OCLN | 100506658 | 1 | 13 | 16 | |
| GSE43470 | OCLN | 100506658 | 1 | 12 | 30 | |
| GSE46452 | OCLN | 100506658 | 0 | 28 | 31 | |
| GSE47630 | OCLN | 100506658 | 1 | 19 | 20 | |
| GSE54993 | OCLN | 100506658 | 8 | 1 | 61 | |
| GSE54994 | OCLN | 100506658 | 1 | 21 | 31 | |
| GSE60625 | OCLN | 100506658 | 0 | 0 | 11 | |
| GSE74703 | OCLN | 100506658 | 1 | 9 | 26 | |
| GSE74704 | OCLN | 100506658 | 1 | 6 | 13 | |
| TCGA | OCLN | 100506658 | 4 | 51 | 41 |
Total number of gains: 19; Total number of losses: 173; Total Number of normals: 296.
Somatic mutations of OCLN:
Generating mutation plots.
Highly correlated genes for OCLN:
Showing top 20/1242 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OCLN | RBM47 | 0.795974 | 12 | 0 | 12 |
| OCLN | SNX24 | 0.794535 | 11 | 0 | 11 |
| OCLN | FCHO2 | 0.792389 | 6 | 0 | 6 |
| OCLN | GRHL1 | 0.788597 | 8 | 0 | 8 |
| OCLN | GDPD3 | 0.782714 | 11 | 0 | 11 |
| OCLN | C15orf48 | 0.782094 | 7 | 0 | 7 |
| OCLN | MAL2 | 0.780475 | 8 | 0 | 8 |
| OCLN | NCCRP1 | 0.77853 | 3 | 0 | 3 |
| OCLN | ACPP | 0.77659 | 11 | 0 | 11 |
| OCLN | BNIPL | 0.77604 | 7 | 0 | 7 |
| OCLN | TMEM154 | 0.774344 | 7 | 0 | 7 |
| OCLN | FAM3D | 0.773863 | 7 | 0 | 7 |
| OCLN | EPS8L1 | 0.770818 | 12 | 0 | 12 |
| OCLN | SCNN1B | 0.767658 | 11 | 0 | 11 |
| OCLN | VSIG10L | 0.767634 | 7 | 0 | 7 |
| OCLN | C18orf25 | 0.76608 | 10 | 0 | 10 |
| OCLN | MALL | 0.765562 | 11 | 0 | 11 |
| OCLN | S100A16 | 0.764041 | 7 | 0 | 7 |
| OCLN | ARHGAP27 | 0.762961 | 8 | 0 | 8 |
| OCLN | LIPH | 0.762751 | 8 | 0 | 8 |
For details and further investigation, click here
