| Full name: one cut homeobox 2 | Alias Symbol: OC-2 | ||
| Type: protein-coding gene | Cytoband: 18q21.31 | ||
| Entrez ID: 9480 | HGNC ID: HGNC:8139 | Ensembl Gene: ENSG00000119547 | OMIM ID: 604894 |
| Drug and gene relationship at DGIdb | |||
Expression of ONECUT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ONECUT2 | 9480 | 230271_at | 0.0945 | 0.6950 | |
| GSE20347 | ONECUT2 | 9480 | 207676_at | 0.0886 | 0.1933 | |
| GSE23400 | ONECUT2 | 9480 | 207676_at | -0.0415 | 0.3000 | |
| GSE26886 | ONECUT2 | 9480 | 230271_at | 0.0245 | 0.8643 | |
| GSE29001 | ONECUT2 | 9480 | 207676_at | -0.0226 | 0.8271 | |
| GSE38129 | ONECUT2 | 9480 | 207676_at | 0.0695 | 0.3245 | |
| GSE45670 | ONECUT2 | 9480 | 230271_at | 0.1271 | 0.3563 | |
| GSE53622 | ONECUT2 | 9480 | 57857 | 0.8876 | 0.0000 | |
| GSE53624 | ONECUT2 | 9480 | 57857 | 1.5542 | 0.0000 | |
| GSE63941 | ONECUT2 | 9480 | 207676_at | 0.1537 | 0.2794 | |
| GSE77861 | ONECUT2 | 9480 | 230271_at | 0.0156 | 0.9144 | |
| SRP007169 | ONECUT2 | 9480 | RNAseq | 3.5514 | 0.0005 | |
| SRP133303 | ONECUT2 | 9480 | RNAseq | 3.2710 | 0.0000 | |
| TCGA | ONECUT2 | 9480 | RNAseq | 0.6529 | 0.0078 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ONECUT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ONECUT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ONECUT2 | 9480 | 2 | 9 | 19 | |
| GSE20123 | ONECUT2 | 9480 | 2 | 9 | 19 | |
| GSE43470 | ONECUT2 | 9480 | 0 | 5 | 38 | |
| GSE46452 | ONECUT2 | 9480 | 1 | 26 | 32 | |
| GSE47630 | ONECUT2 | 9480 | 5 | 20 | 15 | |
| GSE54993 | ONECUT2 | 9480 | 10 | 0 | 60 | |
| GSE54994 | ONECUT2 | 9480 | 0 | 18 | 35 | |
| GSE60625 | ONECUT2 | 9480 | 0 | 4 | 7 | |
| GSE74703 | ONECUT2 | 9480 | 0 | 5 | 31 | |
| GSE74704 | ONECUT2 | 9480 | 2 | 6 | 12 | |
| TCGA | ONECUT2 | 9480 | 9 | 44 | 43 |
Total number of gains: 31; Total number of losses: 146; Total Number of normals: 311.
Somatic mutations of ONECUT2:
Generating mutation plots.
Highly correlated genes for ONECUT2:
Showing top 20/57 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ONECUT2 | C20orf203 | 0.658794 | 3 | 0 | 3 |
| ONECUT2 | GZMK | 0.643127 | 3 | 0 | 3 |
| ONECUT2 | GLOD5 | 0.63496 | 3 | 0 | 3 |
| ONECUT2 | LILRB3 | 0.607015 | 4 | 0 | 3 |
| ONECUT2 | IFNE | 0.600797 | 3 | 0 | 3 |
| ONECUT2 | SNX32 | 0.597017 | 3 | 0 | 3 |
| ONECUT2 | DLL4 | 0.594834 | 3 | 0 | 3 |
| ONECUT2 | TNFSF11 | 0.587098 | 5 | 0 | 3 |
| ONECUT2 | TTI1 | 0.580702 | 3 | 0 | 3 |
| ONECUT2 | CTNND2 | 0.572541 | 3 | 0 | 3 |
| ONECUT2 | GNAO1 | 0.572041 | 4 | 0 | 3 |
| ONECUT2 | MRGBP | 0.570344 | 4 | 0 | 4 |
| ONECUT2 | UBE2U | 0.564373 | 3 | 0 | 3 |
| ONECUT2 | ITIH2 | 0.555929 | 4 | 0 | 3 |
| ONECUT2 | ALKBH2 | 0.555257 | 3 | 0 | 3 |
| ONECUT2 | AMBN | 0.554492 | 5 | 0 | 3 |
| ONECUT2 | SAAL1 | 0.546053 | 3 | 0 | 3 |
| ONECUT2 | DSCAM | 0.545965 | 7 | 0 | 4 |
| ONECUT2 | CBLN4 | 0.544102 | 3 | 0 | 3 |
| ONECUT2 | NOVA2 | 0.542635 | 4 | 0 | 3 |
For details and further investigation, click here
