| Full name: TELO2 interacting protein 1 | Alias Symbol: smg-10 | ||
| Type: protein-coding gene | Cytoband: 20q11.23 | ||
| Entrez ID: 9675 | HGNC ID: HGNC:29029 | Ensembl Gene: ENSG00000101407 | OMIM ID: 614425 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TTI1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of TTI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTI1 | 9675 | 212898_at | 1.1017 | 0.0569 | |
| GSE20347 | TTI1 | 9675 | 212898_at | 1.0238 | 0.0000 | |
| GSE23400 | TTI1 | 9675 | 212898_at | 0.5787 | 0.0000 | |
| GSE26886 | TTI1 | 9675 | 212898_at | 1.0688 | 0.0000 | |
| GSE29001 | TTI1 | 9675 | 212898_at | 1.0671 | 0.0002 | |
| GSE38129 | TTI1 | 9675 | 212898_at | 1.0210 | 0.0000 | |
| GSE45670 | TTI1 | 9675 | 212898_at | 0.8318 | 0.0000 | |
| GSE53622 | TTI1 | 9675 | 141650 | -0.9015 | 0.0000 | |
| GSE53624 | TTI1 | 9675 | 5478 | 0.7334 | 0.0000 | |
| GSE63941 | TTI1 | 9675 | 212898_at | 1.3289 | 0.0048 | |
| GSE77861 | TTI1 | 9675 | 212898_at | 0.6381 | 0.0253 | |
| GSE97050 | TTI1 | 9675 | A_24_P327499 | 0.0136 | 0.9661 | |
| SRP007169 | TTI1 | 9675 | RNAseq | 1.5493 | 0.0008 | |
| SRP008496 | TTI1 | 9675 | RNAseq | 1.6221 | 0.0000 | |
| SRP064894 | TTI1 | 9675 | RNAseq | 0.7663 | 0.0000 | |
| SRP133303 | TTI1 | 9675 | RNAseq | 0.8498 | 0.0000 | |
| SRP159526 | TTI1 | 9675 | RNAseq | 0.8883 | 0.0022 | |
| SRP193095 | TTI1 | 9675 | RNAseq | 0.7327 | 0.0000 | |
| SRP219564 | TTI1 | 9675 | RNAseq | 0.8328 | 0.0034 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by TTI1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of TTI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTI1 | 9675 | 14 | 2 | 14 | |
| GSE20123 | TTI1 | 9675 | 14 | 2 | 14 | |
| GSE43470 | TTI1 | 9675 | 12 | 0 | 31 | |
| GSE46452 | TTI1 | 9675 | 29 | 0 | 30 | |
| GSE47630 | TTI1 | 9675 | 24 | 0 | 16 | |
| GSE54993 | TTI1 | 9675 | 0 | 17 | 53 | |
| GSE54994 | TTI1 | 9675 | 23 | 0 | 30 | |
| GSE60625 | TTI1 | 9675 | 0 | 0 | 11 | |
| GSE74703 | TTI1 | 9675 | 10 | 0 | 26 | |
| GSE74704 | TTI1 | 9675 | 10 | 1 | 9 | |
| TCGA | TTI1 | 9675 | 48 | 3 | 45 |
Total number of gains: 184; Total number of losses: 25; Total Number of normals: 279.
Somatic mutations of TTI1:
Generating mutation plots.
Highly correlated genes for TTI1:
Showing top 20/272 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTI1 | RAE1 | 0.744567 | 10 | 0 | 9 |
| TTI1 | TAF4 | 0.726861 | 10 | 0 | 9 |
| TTI1 | IPO9 | 0.707521 | 9 | 0 | 9 |
| TTI1 | PPP1R16A | 0.703156 | 3 | 0 | 3 |
| TTI1 | RAD54L | 0.682769 | 8 | 0 | 8 |
| TTI1 | MTERF3 | 0.681271 | 8 | 0 | 8 |
| TTI1 | RPRD1B | 0.680659 | 4 | 0 | 4 |
| TTI1 | TMEM132A | 0.675629 | 8 | 0 | 8 |
| TTI1 | PSMA7 | 0.672462 | 10 | 0 | 8 |
| TTI1 | PLCG1 | 0.664696 | 7 | 0 | 6 |
| TTI1 | ENTPD6 | 0.659765 | 8 | 0 | 7 |
| TTI1 | TMEM223 | 0.657928 | 8 | 0 | 7 |
| TTI1 | TOMM34 | 0.656556 | 10 | 0 | 9 |
| TTI1 | TIMMDC1 | 0.651039 | 4 | 0 | 4 |
| TTI1 | FEN1 | 0.648646 | 10 | 0 | 9 |
| TTI1 | AAR2 | 0.646858 | 9 | 0 | 8 |
| TTI1 | IMMP1L | 0.641511 | 3 | 0 | 3 |
| TTI1 | MRPS17 | 0.640871 | 9 | 0 | 7 |
| TTI1 | AP2A1 | 0.640467 | 3 | 0 | 3 |
| TTI1 | RBM28 | 0.639546 | 9 | 0 | 8 |
For details and further investigation, click here
