| Full name: PBX homeobox 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 80714 | HGNC ID: HGNC:13403 | Ensembl Gene: ENSG00000105717 | OMIM ID: 608127 |
| Drug and gene relationship at DGIdb | |||
Expression of PBX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PBX4 | 80714 | 230536_at | 0.5427 | 0.1071 | |
| GSE26886 | PBX4 | 80714 | 230536_at | 0.8097 | 0.0003 | |
| GSE45670 | PBX4 | 80714 | 230536_at | 0.3688 | 0.0605 | |
| GSE53622 | PBX4 | 80714 | 70408 | 0.5547 | 0.0000 | |
| GSE53624 | PBX4 | 80714 | 70408 | 0.5873 | 0.0000 | |
| GSE63941 | PBX4 | 80714 | 230536_at | 0.7228 | 0.0721 | |
| GSE77861 | PBX4 | 80714 | 230536_at | 0.0165 | 0.9314 | |
| GSE97050 | PBX4 | 80714 | A_23_P90419 | 0.3164 | 0.2272 | |
| SRP064894 | PBX4 | 80714 | RNAseq | 0.6978 | 0.0020 | |
| SRP133303 | PBX4 | 80714 | RNAseq | 0.5450 | 0.0793 | |
| SRP159526 | PBX4 | 80714 | RNAseq | 0.2133 | 0.7587 | |
| SRP219564 | PBX4 | 80714 | RNAseq | 1.1825 | 0.0168 | |
| TCGA | PBX4 | 80714 | RNAseq | 0.1557 | 0.6046 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PBX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PBX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PBX4 | 80714 | 4 | 5 | 21 | |
| GSE20123 | PBX4 | 80714 | 3 | 3 | 24 | |
| GSE43470 | PBX4 | 80714 | 2 | 5 | 36 | |
| GSE46452 | PBX4 | 80714 | 47 | 1 | 11 | |
| GSE47630 | PBX4 | 80714 | 5 | 8 | 27 | |
| GSE54993 | PBX4 | 80714 | 16 | 4 | 50 | |
| GSE54994 | PBX4 | 80714 | 6 | 13 | 34 | |
| GSE60625 | PBX4 | 80714 | 9 | 0 | 2 | |
| GSE74703 | PBX4 | 80714 | 2 | 3 | 31 | |
| GSE74704 | PBX4 | 80714 | 0 | 3 | 17 | |
| TCGA | PBX4 | 80714 | 16 | 10 | 70 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of PBX4:
Generating mutation plots.
Highly correlated genes for PBX4:
Showing top 20/340 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PBX4 | PLA2G15 | 0.747445 | 3 | 0 | 3 |
| PBX4 | MEST | 0.707152 | 3 | 0 | 3 |
| PBX4 | NUP43 | 0.662584 | 4 | 0 | 4 |
| PBX4 | ZBTB17 | 0.654306 | 5 | 0 | 4 |
| PBX4 | TTC13 | 0.65224 | 4 | 0 | 3 |
| PBX4 | TOMM40 | 0.65045 | 4 | 0 | 3 |
| PBX4 | BAIAP2L2 | 0.647788 | 3 | 0 | 3 |
| PBX4 | NADK | 0.646461 | 5 | 0 | 5 |
| PBX4 | ATP11A | 0.642196 | 3 | 0 | 3 |
| PBX4 | AP2A1 | 0.639539 | 4 | 0 | 4 |
| PBX4 | TRMT2A | 0.639052 | 3 | 0 | 3 |
| PBX4 | CSNK1G2 | 0.63701 | 5 | 0 | 4 |
| PBX4 | RUVBL1 | 0.634659 | 4 | 0 | 3 |
| PBX4 | IGF2BP2 | 0.633648 | 4 | 0 | 3 |
| PBX4 | PLA2G7 | 0.63127 | 5 | 0 | 4 |
| PBX4 | INTS1 | 0.629772 | 4 | 0 | 3 |
| PBX4 | ETV7 | 0.627877 | 5 | 0 | 5 |
| PBX4 | TAP1 | 0.626933 | 4 | 0 | 3 |
| PBX4 | SNRPC | 0.626688 | 4 | 0 | 3 |
| PBX4 | LAMA5 | 0.625355 | 3 | 0 | 3 |
For details and further investigation, click here
