DSN1

 

Full name: DSN1 component of MIS12 kinetochore complex Alias Symbol: dJ469A13.2|MIS13|KNL3|hKNL-3
Type: protein-coding gene Cytoband: 20q11.23
Entrez ID: 79980 HGNC ID: HGNC:16165 Ensembl Gene: ENSG00000149636 OMIM ID: 609175
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DSN1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DSN1 79980 219512_at 0.9524 0.0399
GSE20347 DSN1 79980 219512_at 0.9837 0.0000
GSE23400 DSN1 79980 219512_at 0.3955 0.0000
GSE26886 DSN1 79980 219512_at 0.0688 0.7183
GSE29001 DSN1 79980 219512_at 1.0422 0.0007
GSE38129 DSN1 79980 219512_at 1.1617 0.0000
GSE45670 DSN1 79980 219512_at 0.7744 0.0000
GSE53622 DSN1 79980 136859 0.9494 0.0000
GSE53624 DSN1 79980 136859 0.9401 0.0000
GSE63941 DSN1 79980 219512_at 0.7999 0.1821
GSE77861 DSN1 79980 219512_at 0.4699 0.0168
GSE97050 DSN1 79980 A_23_P165937 0.3226 0.6149
SRP007169 DSN1 79980 RNAseq 0.7319 0.0790
SRP008496 DSN1 79980 RNAseq 1.0385 0.0001
SRP064894 DSN1 79980 RNAseq 1.1290 0.0000
SRP133303 DSN1 79980 RNAseq 0.9156 0.0000
SRP159526 DSN1 79980 RNAseq 0.8866 0.0037
SRP193095 DSN1 79980 RNAseq 0.5029 0.0000
SRP219564 DSN1 79980 RNAseq 1.0269 0.0025
TCGA DSN1 79980 RNAseq 0.4308 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by DSN1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DSN1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DSN1 79980 14 2 14
GSE20123 DSN1 79980 14 2 14
GSE43470 DSN1 79980 12 0 31
GSE46452 DSN1 79980 29 0 30
GSE47630 DSN1 79980 24 0 16
GSE54993 DSN1 79980 0 17 53
GSE54994 DSN1 79980 24 0 29
GSE60625 DSN1 79980 0 0 11
GSE74703 DSN1 79980 11 0 25
GSE74704 DSN1 79980 10 1 9
TCGA DSN1 79980 49 3 44

Total number of gains: 187; Total number of losses: 25; Total Number of normals: 276.  

 

Somatic mutations of DSN1:

 

Generating mutation plots.

 

Highly correlated genes for DSN1:

 

Showing top 20/1413 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DSN1GINS10.76270611011
DSN1CMSS10.74646505
DSN1CDC60.744654808
DSN1ACTL6A0.7334381009
DSN1MYBL20.73214411011
DSN1PRIM20.728386909
DSN1RPN20.723991009
DSN1ERCC6L0.72277510010
DSN1AURKA0.71851912011
DSN1MTFR20.715283606
DSN1C18orf540.715012505
DSN1UBE2C0.71419912012
DSN1CDCA50.713405706
DSN1NUDT10.7131911010
DSN1DTYMK0.71251410010
DSN1MAD2L10.71244411010
DSN1CSTF10.71213411011
DSN1RFC40.71196412010
DSN1ORC60.70925311010
DSN1DLGAP50.70917411010

For details and further investigation, click here