| Full name: protein kinase C and casein kinase substrate in neurons 1 | Alias Symbol: SDPI | ||
| Type: protein-coding gene | Cytoband: 6p21.3 | ||
| Entrez ID: 29993 | HGNC ID: HGNC:8570 | Ensembl Gene: ENSG00000124507 | OMIM ID: 606512 |
| Drug and gene relationship at DGIdb | |||
Expression of PACSIN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PACSIN1 | 29993 | 224360_s_at | 0.1193 | 0.6675 | |
| GSE26886 | PACSIN1 | 29993 | 224360_s_at | 0.0368 | 0.8354 | |
| GSE45670 | PACSIN1 | 29993 | 224360_s_at | -0.2130 | 0.0442 | |
| GSE53622 | PACSIN1 | 29993 | 124291 | -2.8098 | 0.0000 | |
| GSE53624 | PACSIN1 | 29993 | 124291 | -1.4234 | 0.0000 | |
| GSE63941 | PACSIN1 | 29993 | 224360_s_at | -0.0956 | 0.5531 | |
| GSE77861 | PACSIN1 | 29993 | 227053_at | 0.0090 | 0.9628 | |
| TCGA | PACSIN1 | 29993 | RNAseq | -1.6238 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PACSIN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PACSIN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PACSIN1 | 29993 | 5 | 0 | 25 | |
| GSE20123 | PACSIN1 | 29993 | 5 | 0 | 25 | |
| GSE43470 | PACSIN1 | 29993 | 5 | 1 | 37 | |
| GSE46452 | PACSIN1 | 29993 | 2 | 9 | 48 | |
| GSE47630 | PACSIN1 | 29993 | 8 | 4 | 28 | |
| GSE54993 | PACSIN1 | 29993 | 3 | 1 | 66 | |
| GSE54994 | PACSIN1 | 29993 | 11 | 4 | 38 | |
| GSE60625 | PACSIN1 | 29993 | 1 | 0 | 10 | |
| GSE74703 | PACSIN1 | 29993 | 5 | 0 | 31 | |
| GSE74704 | PACSIN1 | 29993 | 2 | 0 | 18 | |
| TCGA | PACSIN1 | 29993 | 16 | 15 | 65 |
Total number of gains: 63; Total number of losses: 34; Total Number of normals: 391.
Somatic mutations of PACSIN1:
Generating mutation plots.
Highly correlated genes for PACSIN1:
Showing top 20/126 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PACSIN1 | STK40 | 0.680957 | 3 | 0 | 3 |
| PACSIN1 | ANKRD35 | 0.675803 | 3 | 0 | 3 |
| PACSIN1 | C5orf66-AS1 | 0.669585 | 3 | 0 | 3 |
| PACSIN1 | EMP1 | 0.667106 | 3 | 0 | 3 |
| PACSIN1 | FNDC4 | 0.666051 | 3 | 0 | 3 |
| PACSIN1 | TP53I3 | 0.661743 | 3 | 0 | 3 |
| PACSIN1 | CHP1 | 0.660616 | 3 | 0 | 3 |
| PACSIN1 | LMO7 | 0.658708 | 3 | 0 | 3 |
| PACSIN1 | MAPK3 | 0.658179 | 3 | 0 | 3 |
| PACSIN1 | SASH1 | 0.65624 | 3 | 0 | 3 |
| PACSIN1 | CYSRT1 | 0.654154 | 3 | 0 | 3 |
| PACSIN1 | IKZF2 | 0.653544 | 3 | 0 | 3 |
| PACSIN1 | SERPINB6 | 0.652291 | 3 | 0 | 3 |
| PACSIN1 | GPD1L | 0.649928 | 3 | 0 | 3 |
| PACSIN1 | TREML2 | 0.649598 | 3 | 0 | 3 |
| PACSIN1 | SHROOM3 | 0.647971 | 3 | 0 | 3 |
| PACSIN1 | PITX1 | 0.647393 | 3 | 0 | 3 |
| PACSIN1 | USP54 | 0.646561 | 3 | 0 | 3 |
| PACSIN1 | VSIG2 | 0.646276 | 3 | 0 | 3 |
| PACSIN1 | PLEKHM1 | 0.64417 | 4 | 0 | 4 |
For details and further investigation, click here
