| Full name: p21 (RAC1) activated kinase 3 | Alias Symbol: hPAK3|bPAK | ||
| Type: protein-coding gene | Cytoband: Xq23 | ||
| Entrez ID: 5063 | HGNC ID: HGNC:8592 | Ensembl Gene: ENSG00000077264 | OMIM ID: 300142 |
| Drug and gene relationship at DGIdb | |||
PAK3 involved pathways:
Expression of PAK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAK3 | 5063 | 214607_at | -0.3512 | 0.4210 | |
| GSE20347 | PAK3 | 5063 | 214607_at | 0.2022 | 0.2283 | |
| GSE23400 | PAK3 | 5063 | 214607_at | -0.1920 | 0.0001 | |
| GSE26886 | PAK3 | 5063 | 214607_at | 0.3018 | 0.2862 | |
| GSE29001 | PAK3 | 5063 | 214607_at | 0.1732 | 0.7673 | |
| GSE38129 | PAK3 | 5063 | 214607_at | -0.3051 | 0.0963 | |
| GSE45670 | PAK3 | 5063 | 214607_at | -0.5853 | 0.0003 | |
| GSE53622 | PAK3 | 5063 | 27997 | -1.5006 | 0.0000 | |
| GSE53624 | PAK3 | 5063 | 27997 | -1.2536 | 0.0000 | |
| GSE63941 | PAK3 | 5063 | 214607_at | -0.9042 | 0.0126 | |
| GSE77861 | PAK3 | 5063 | 214607_at | -0.0137 | 0.9342 | |
| SRP007169 | PAK3 | 5063 | RNAseq | 1.6199 | 0.0721 | |
| SRP064894 | PAK3 | 5063 | RNAseq | -0.4335 | 0.2608 | |
| SRP133303 | PAK3 | 5063 | RNAseq | -0.7995 | 0.0054 | |
| SRP159526 | PAK3 | 5063 | RNAseq | 0.9001 | 0.2733 | |
| SRP193095 | PAK3 | 5063 | RNAseq | -0.0557 | 0.8745 | |
| SRP219564 | PAK3 | 5063 | RNAseq | -0.4585 | 0.5165 | |
| TCGA | PAK3 | 5063 | RNAseq | -2.5847 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PAK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAK3:
No record found for this gene.
Somatic mutations of PAK3:
Generating mutation plots.
Highly correlated genes for PAK3:
Showing top 20/503 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAK3 | BEND5 | 0.680932 | 7 | 0 | 7 |
| PAK3 | MACROD2 | 0.659121 | 3 | 0 | 3 |
| PAK3 | APOD | 0.654481 | 6 | 0 | 5 |
| PAK3 | FGF3 | 0.652647 | 5 | 0 | 4 |
| PAK3 | ENPP6 | 0.649003 | 5 | 0 | 5 |
| PAK3 | ITGA9 | 0.64339 | 7 | 0 | 7 |
| PAK3 | MYOCD | 0.63444 | 4 | 0 | 4 |
| PAK3 | DDAH2 | 0.63195 | 4 | 0 | 4 |
| PAK3 | ADM2 | 0.629554 | 3 | 0 | 3 |
| PAK3 | AKAP3 | 0.629361 | 3 | 0 | 3 |
| PAK3 | GRK5 | 0.624905 | 3 | 0 | 3 |
| PAK3 | FCGRT | 0.624795 | 5 | 0 | 4 |
| PAK3 | ST6GALNAC3 | 0.624719 | 6 | 0 | 6 |
| PAK3 | STXBP6 | 0.624605 | 7 | 0 | 6 |
| PAK3 | PARM1 | 0.624405 | 9 | 0 | 7 |
| PAK3 | EFCAB1 | 0.623176 | 4 | 0 | 3 |
| PAK3 | CGNL1 | 0.621561 | 4 | 0 | 4 |
| PAK3 | KCNT2 | 0.620474 | 6 | 0 | 5 |
| PAK3 | SMTNL2 | 0.620118 | 5 | 0 | 5 |
| PAK3 | PPP1R12B | 0.619901 | 4 | 0 | 4 |
For details and further investigation, click here
