| Full name: par-6 family cell polarity regulator alpha | Alias Symbol: PAR-6|PAR-6A|TAX40|PAR6alpha|TIP-40 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 50855 | HGNC ID: HGNC:15943 | Ensembl Gene: ENSG00000102981 | OMIM ID: 607484 |
PARD6A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04360 | Axon guidance | |
| hsa04530 | Tight junction |
Expression of PARD6A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARD6A | 50855 | 205245_at | -0.0868 | 0.8013 | |
| GSE20347 | PARD6A | 50855 | 205245_at | 0.0717 | 0.4596 | |
| GSE23400 | PARD6A | 50855 | 205245_at | -0.0931 | 0.0092 | |
| GSE26886 | PARD6A | 50855 | 205245_at | 0.0464 | 0.7815 | |
| GSE29001 | PARD6A | 50855 | 205245_at | -0.0821 | 0.5513 | |
| GSE38129 | PARD6A | 50855 | 205245_at | -0.1359 | 0.1301 | |
| GSE45670 | PARD6A | 50855 | 205245_at | -0.0592 | 0.5724 | |
| GSE53622 | PARD6A | 50855 | 142520 | -0.3691 | 0.0000 | |
| GSE53624 | PARD6A | 50855 | 142520 | -0.3056 | 0.0006 | |
| GSE63941 | PARD6A | 50855 | 205245_at | 0.8206 | 0.0057 | |
| GSE77861 | PARD6A | 50855 | 205245_at | -0.0481 | 0.8178 | |
| GSE97050 | PARD6A | 50855 | A_23_P140821 | -0.2938 | 0.6526 | |
| SRP064894 | PARD6A | 50855 | RNAseq | 0.2140 | 0.6331 | |
| SRP133303 | PARD6A | 50855 | RNAseq | -0.5889 | 0.1565 | |
| SRP159526 | PARD6A | 50855 | RNAseq | 0.1909 | 0.7110 | |
| SRP219564 | PARD6A | 50855 | RNAseq | -1.0089 | 0.1829 | |
| TCGA | PARD6A | 50855 | RNAseq | -0.6748 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PARD6A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARD6A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARD6A | 50855 | 9 | 2 | 19 | |
| GSE20123 | PARD6A | 50855 | 9 | 2 | 19 | |
| GSE43470 | PARD6A | 50855 | 1 | 9 | 33 | |
| GSE46452 | PARD6A | 50855 | 38 | 1 | 20 | |
| GSE47630 | PARD6A | 50855 | 11 | 8 | 21 | |
| GSE54993 | PARD6A | 50855 | 2 | 4 | 64 | |
| GSE54994 | PARD6A | 50855 | 8 | 10 | 35 | |
| GSE60625 | PARD6A | 50855 | 4 | 0 | 7 | |
| GSE74703 | PARD6A | 50855 | 1 | 6 | 29 | |
| GSE74704 | PARD6A | 50855 | 5 | 1 | 14 | |
| TCGA | PARD6A | 50855 | 29 | 12 | 55 |
Total number of gains: 117; Total number of losses: 55; Total Number of normals: 316.
Somatic mutations of PARD6A:
Generating mutation plots.
Highly correlated genes for PARD6A:
Showing top 20/310 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARD6A | PGC | 0.694561 | 3 | 0 | 3 |
| PARD6A | ZNF524 | 0.669884 | 3 | 0 | 3 |
| PARD6A | GPD1 | 0.657709 | 4 | 0 | 4 |
| PARD6A | UBOX5 | 0.652983 | 4 | 0 | 4 |
| PARD6A | HMCN2 | 0.641842 | 3 | 0 | 3 |
| PARD6A | SLC5A11 | 0.638526 | 3 | 0 | 3 |
| PARD6A | GPAT2 | 0.636372 | 3 | 0 | 3 |
| PARD6A | BSND | 0.636267 | 4 | 0 | 4 |
| PARD6A | SYCP3 | 0.627414 | 3 | 0 | 3 |
| PARD6A | LMAN1L | 0.626283 | 8 | 0 | 7 |
| PARD6A | CD70 | 0.624484 | 4 | 0 | 3 |
| PARD6A | WDR60 | 0.616748 | 4 | 0 | 3 |
| PARD6A | DOC2B | 0.615956 | 6 | 0 | 5 |
| PARD6A | TCL6 | 0.613761 | 4 | 0 | 4 |
| PARD6A | PGBD2 | 0.612847 | 3 | 0 | 3 |
| PARD6A | KLHL35 | 0.603641 | 5 | 0 | 4 |
| PARD6A | POLM | 0.601536 | 5 | 0 | 4 |
| PARD6A | LINC00950 | 0.599423 | 5 | 0 | 5 |
| PARD6A | MYBPC3 | 0.597813 | 5 | 0 | 5 |
| PARD6A | PDCD1 | 0.596929 | 6 | 0 | 5 |
For details and further investigation, click here
