| Full name: pyruvate carboxylase | Alias Symbol: PCB | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 5091 | HGNC ID: HGNC:8636 | Ensembl Gene: ENSG00000173599 | OMIM ID: 608786 |
| Drug and gene relationship at DGIdb | |||
Expression of PC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PC | 5091 | 204476_s_at | 1.3093 | 0.0725 | |
| GSE20347 | PC | 5091 | 204476_s_at | 0.7908 | 0.0054 | |
| GSE23400 | PC | 5091 | 204476_s_at | 0.3664 | 0.0001 | |
| GSE26886 | PC | 5091 | 204476_s_at | 0.6614 | 0.0163 | |
| GSE29001 | PC | 5091 | 204476_s_at | 0.3962 | 0.3241 | |
| GSE38129 | PC | 5091 | 204476_s_at | 0.8018 | 0.0037 | |
| GSE45670 | PC | 5091 | 204476_s_at | 1.3014 | 0.0004 | |
| GSE53622 | PC | 5091 | 22650 | 0.6183 | 0.0000 | |
| GSE53624 | PC | 5091 | 22650 | 0.8369 | 0.0000 | |
| GSE63941 | PC | 5091 | 204476_s_at | 0.0768 | 0.9121 | |
| GSE77861 | PC | 5091 | 204476_s_at | 0.6293 | 0.0748 | |
| GSE97050 | PC | 5091 | A_33_P3244347 | 0.4371 | 0.2779 | |
| SRP007169 | PC | 5091 | RNAseq | 1.6845 | 0.0003 | |
| SRP008496 | PC | 5091 | RNAseq | 0.7420 | 0.1019 | |
| SRP064894 | PC | 5091 | RNAseq | 0.7154 | 0.0032 | |
| SRP133303 | PC | 5091 | RNAseq | 1.1865 | 0.0001 | |
| SRP159526 | PC | 5091 | RNAseq | 1.7755 | 0.0031 | |
| SRP193095 | PC | 5091 | RNAseq | 1.3953 | 0.0000 | |
| SRP219564 | PC | 5091 | RNAseq | 0.8246 | 0.3016 | |
| TCGA | PC | 5091 | RNAseq | 0.2773 | 0.0078 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by PC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PC | 5091 | 9 | 3 | 18 | |
| GSE20123 | PC | 5091 | 9 | 3 | 18 | |
| GSE43470 | PC | 5091 | 6 | 1 | 36 | |
| GSE46452 | PC | 5091 | 12 | 3 | 44 | |
| GSE47630 | PC | 5091 | 9 | 4 | 27 | |
| GSE54993 | PC | 5091 | 3 | 0 | 67 | |
| GSE54994 | PC | 5091 | 12 | 7 | 34 | |
| GSE60625 | PC | 5091 | 0 | 3 | 8 | |
| GSE74703 | PC | 5091 | 4 | 0 | 32 | |
| GSE74704 | PC | 5091 | 7 | 1 | 12 | |
| TCGA | PC | 5091 | 25 | 9 | 62 |
Total number of gains: 96; Total number of losses: 34; Total Number of normals: 358.
Somatic mutations of PC:
Generating mutation plots.
Highly correlated genes for PC:
Showing top 20/554 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PC | POLR1A | 0.733093 | 3 | 0 | 3 |
| PC | CYB561A3 | 0.69964 | 3 | 0 | 3 |
| PC | PSMG3 | 0.680167 | 4 | 0 | 4 |
| PC | C4orf46 | 0.67979 | 3 | 0 | 3 |
| PC | MTFP1 | 0.674278 | 5 | 0 | 4 |
| PC | POLE4 | 0.673845 | 6 | 0 | 5 |
| PC | SCLY | 0.667798 | 4 | 0 | 4 |
| PC | CD276 | 0.667403 | 5 | 0 | 5 |
| PC | EME1 | 0.665742 | 4 | 0 | 4 |
| PC | CDCA5 | 0.663613 | 7 | 0 | 6 |
| PC | POU6F2-AS2 | 0.663596 | 4 | 0 | 4 |
| PC | HAUS8 | 0.662571 | 6 | 0 | 4 |
| PC | ENOX2 | 0.659304 | 4 | 0 | 4 |
| PC | MIB2 | 0.654909 | 4 | 0 | 3 |
| PC | CDCA2 | 0.654613 | 4 | 0 | 3 |
| PC | STEAP1B | 0.653518 | 6 | 0 | 6 |
| PC | CASC15 | 0.648153 | 4 | 0 | 4 |
| PC | RCC1 | 0.64755 | 4 | 0 | 4 |
| PC | LRR1 | 0.644135 | 5 | 0 | 3 |
| PC | WFDC5 | 0.643427 | 4 | 0 | 3 |
For details and further investigation, click here
