| Full name: period circadian regulator 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.23 | ||
| Entrez ID: 8863 | HGNC ID: HGNC:8847 | Ensembl Gene: ENSG00000049246 | OMIM ID: 603427 |
| Drug and gene relationship at DGIdb | |||
PER3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04710 | Circadian rhythm | |
| hsa04713 | Circadian entrainment |
Expression of PER3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PER3 | 8863 | 221045_s_at | -0.2159 | 0.8659 | |
| GSE20347 | PER3 | 8863 | 221045_s_at | -1.0215 | 0.0062 | |
| GSE23400 | PER3 | 8863 | 221045_s_at | -0.7534 | 0.0000 | |
| GSE26886 | PER3 | 8863 | 221045_s_at | -1.9721 | 0.0002 | |
| GSE29001 | PER3 | 8863 | 221045_s_at | -1.1595 | 0.0523 | |
| GSE38129 | PER3 | 8863 | 221045_s_at | -1.1929 | 0.0000 | |
| GSE45670 | PER3 | 8863 | 221045_s_at | -1.1136 | 0.0580 | |
| GSE53622 | PER3 | 8863 | 2854 | -1.2674 | 0.0000 | |
| GSE53624 | PER3 | 8863 | 48881 | -1.5416 | 0.0000 | |
| GSE63941 | PER3 | 8863 | 221045_s_at | 0.2689 | 0.8262 | |
| GSE77861 | PER3 | 8863 | 221045_s_at | -1.7911 | 0.0060 | |
| GSE97050 | PER3 | 8863 | A_24_P230948 | -0.4121 | 0.6594 | |
| SRP007169 | PER3 | 8863 | RNAseq | -0.7342 | 0.2769 | |
| SRP064894 | PER3 | 8863 | RNAseq | -0.9082 | 0.0045 | |
| SRP133303 | PER3 | 8863 | RNAseq | -0.6603 | 0.1036 | |
| SRP159526 | PER3 | 8863 | RNAseq | -0.9526 | 0.1986 | |
| SRP193095 | PER3 | 8863 | RNAseq | -1.3353 | 0.0000 | |
| SRP219564 | PER3 | 8863 | RNAseq | -0.8858 | 0.3169 | |
| TCGA | PER3 | 8863 | RNAseq | -0.3697 | 0.0055 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by PER3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PER3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PER3 | 8863 | 2 | 5 | 23 | |
| GSE20123 | PER3 | 8863 | 2 | 4 | 24 | |
| GSE43470 | PER3 | 8863 | 6 | 5 | 32 | |
| GSE46452 | PER3 | 8863 | 7 | 1 | 51 | |
| GSE47630 | PER3 | 8863 | 8 | 4 | 28 | |
| GSE54993 | PER3 | 8863 | 3 | 2 | 65 | |
| GSE54994 | PER3 | 8863 | 14 | 3 | 36 | |
| GSE60625 | PER3 | 8863 | 0 | 0 | 11 | |
| GSE74703 | PER3 | 8863 | 5 | 3 | 28 | |
| GSE74704 | PER3 | 8863 | 2 | 0 | 18 | |
| TCGA | PER3 | 8863 | 11 | 22 | 63 |
Total number of gains: 60; Total number of losses: 49; Total Number of normals: 379.
Somatic mutations of PER3:
Generating mutation plots.
Highly correlated genes for PER3:
Showing top 20/654 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PER3 | TTC33 | 0.803571 | 3 | 0 | 3 |
| PER3 | SLC25A27 | 0.721854 | 3 | 0 | 3 |
| PER3 | C5orf51 | 0.712989 | 3 | 0 | 3 |
| PER3 | TSNARE1 | 0.711915 | 3 | 0 | 3 |
| PER3 | ZNF784 | 0.693269 | 4 | 0 | 4 |
| PER3 | CACNA2D1 | 0.690581 | 3 | 0 | 3 |
| PER3 | PRIMA1 | 0.688853 | 3 | 0 | 3 |
| PER3 | ANO5 | 0.667778 | 4 | 0 | 3 |
| PER3 | PHF13 | 0.667382 | 3 | 0 | 3 |
| PER3 | LETMD1 | 0.666511 | 3 | 0 | 3 |
| PER3 | CYP2U1 | 0.656945 | 4 | 0 | 3 |
| PER3 | THRB | 0.654594 | 4 | 0 | 3 |
| PER3 | EIF4E3 | 0.653302 | 7 | 0 | 6 |
| PER3 | VEZF1 | 0.652887 | 4 | 0 | 3 |
| PER3 | PRADC1 | 0.651777 | 3 | 0 | 3 |
| PER3 | C1QTNF7 | 0.650916 | 6 | 0 | 5 |
| PER3 | NR1D2 | 0.650464 | 12 | 0 | 8 |
| PER3 | GFRA3 | 0.649976 | 3 | 0 | 3 |
| PER3 | RGMB | 0.649491 | 4 | 0 | 3 |
| PER3 | LSM14A | 0.646993 | 3 | 0 | 3 |
For details and further investigation, click here
