| Full name: PH domain and leucine rich repeat protein phosphatase 1 | Alias Symbol: KIAA0606|SCOP|PPM3A | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 23239 | HGNC ID: HGNC:20610 | Ensembl Gene: ENSG00000081913 | OMIM ID: 609396 |
PHLPP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway |
Expression of PHLPP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHLPP1 | 23239 | 212719_at | -0.0091 | 0.9938 | |
| GSE20347 | PHLPP1 | 23239 | 212719_at | -0.0786 | 0.7310 | |
| GSE23400 | PHLPP1 | 23239 | 212719_at | -0.0742 | 0.4058 | |
| GSE26886 | PHLPP1 | 23239 | 212719_at | -0.1752 | 0.4635 | |
| GSE29001 | PHLPP1 | 23239 | 212719_at | -0.0629 | 0.8431 | |
| GSE38129 | PHLPP1 | 23239 | 212719_at | -0.0619 | 0.7455 | |
| GSE45670 | PHLPP1 | 23239 | 212719_at | -0.2794 | 0.2469 | |
| GSE63941 | PHLPP1 | 23239 | 212719_at | 1.6486 | 0.0218 | |
| GSE77861 | PHLPP1 | 23239 | 212719_at | 0.3013 | 0.6203 | |
| GSE97050 | PHLPP1 | 23239 | A_23_P89762 | -0.1806 | 0.3867 | |
| SRP007169 | PHLPP1 | 23239 | RNAseq | -0.8663 | 0.0189 | |
| SRP008496 | PHLPP1 | 23239 | RNAseq | -0.8695 | 0.0002 | |
| SRP064894 | PHLPP1 | 23239 | RNAseq | -0.8159 | 0.0000 | |
| SRP133303 | PHLPP1 | 23239 | RNAseq | -0.3013 | 0.1634 | |
| SRP159526 | PHLPP1 | 23239 | RNAseq | 0.2006 | 0.2860 | |
| SRP193095 | PHLPP1 | 23239 | RNAseq | -0.3639 | 0.0008 | |
| SRP219564 | PHLPP1 | 23239 | RNAseq | -0.9176 | 0.0110 | |
| TCGA | PHLPP1 | 23239 | RNAseq | -0.0160 | 0.8053 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PHLPP1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PHLPP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHLPP1 | 23239 | 1 | 9 | 20 | |
| GSE20123 | PHLPP1 | 23239 | 1 | 9 | 20 | |
| GSE43470 | PHLPP1 | 23239 | 0 | 7 | 36 | |
| GSE46452 | PHLPP1 | 23239 | 1 | 26 | 32 | |
| GSE47630 | PHLPP1 | 23239 | 5 | 21 | 14 | |
| GSE54993 | PHLPP1 | 23239 | 9 | 0 | 61 | |
| GSE54994 | PHLPP1 | 23239 | 1 | 18 | 34 | |
| GSE60625 | PHLPP1 | 23239 | 0 | 4 | 7 | |
| GSE74703 | PHLPP1 | 23239 | 0 | 7 | 29 | |
| GSE74704 | PHLPP1 | 23239 | 1 | 6 | 13 | |
| TCGA | PHLPP1 | 23239 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of PHLPP1:
Generating mutation plots.
Highly correlated genes for PHLPP1:
Showing top 20/143 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHLPP1 | FOPNL | 0.771106 | 3 | 0 | 3 |
| PHLPP1 | CAND1 | 0.759045 | 3 | 0 | 3 |
| PHLPP1 | SMURF1 | 0.74798 | 3 | 0 | 3 |
| PHLPP1 | POLR2G | 0.747862 | 3 | 0 | 3 |
| PHLPP1 | CLEC16A | 0.742529 | 3 | 0 | 3 |
| PHLPP1 | STK35 | 0.738271 | 3 | 0 | 3 |
| PHLPP1 | PIGS | 0.730514 | 3 | 0 | 3 |
| PHLPP1 | FASTKD2 | 0.724532 | 3 | 0 | 3 |
| PHLPP1 | PLEKHA7 | 0.716146 | 3 | 0 | 3 |
| PHLPP1 | TUFM | 0.713485 | 3 | 0 | 3 |
| PHLPP1 | MRPL38 | 0.711738 | 3 | 0 | 3 |
| PHLPP1 | CD2BP2 | 0.702137 | 3 | 0 | 3 |
| PHLPP1 | OSBPL9 | 0.701011 | 3 | 0 | 3 |
| PHLPP1 | STX10 | 0.699291 | 3 | 0 | 3 |
| PHLPP1 | CDC14A | 0.694568 | 3 | 0 | 3 |
| PHLPP1 | SORL1 | 0.691129 | 3 | 0 | 3 |
| PHLPP1 | COMMD2 | 0.689168 | 3 | 0 | 3 |
| PHLPP1 | COG1 | 0.686228 | 3 | 0 | 3 |
| PHLPP1 | FAM192A | 0.677654 | 3 | 0 | 3 |
| PHLPP1 | AKAP9 | 0.677408 | 3 | 0 | 3 |
For details and further investigation, click here
