PIK3R2

 

Full name: phosphoinositide-3-kinase regulatory subunit 2 Alias Symbol: P85B|p85
Type: protein-coding gene Cytoband: 19p13.11
Entrez ID: 5296 HGNC ID: HGNC:8980 Ensembl Gene: ENSG00000105647 OMIM ID: 603157
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PIK3R2 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04960Aldosterone-regulated sodium reabsorption
hsa04973Carbohydrate digestion and absorption
hsa05100Bacterial invasion of epithelial cells
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PIK3R2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PIK3R2 5296 1568629_s_at 0.5345 0.2732
GSE20347 PIK3R2 5296 207105_s_at -0.1796 0.0230
GSE23400 PIK3R2 5296 207105_s_at -0.0828 0.0574
GSE26886 PIK3R2 5296 1568629_s_at 0.5422 0.0003
GSE29001 PIK3R2 5296 207105_s_at -0.3182 0.0403
GSE38129 PIK3R2 5296 207105_s_at -0.0595 0.6557
GSE45670 PIK3R2 5296 1568629_s_at 0.2619 0.0669
GSE53622 PIK3R2 5296 124771 -0.1286 0.0578
GSE53624 PIK3R2 5296 124771 -0.0291 0.7453
GSE63941 PIK3R2 5296 1568629_s_at -0.8757 0.0323
GSE77861 PIK3R2 5296 1568629_s_at 0.0739 0.7325
GSE97050 PIK3R2 5296 A_33_P3367855 -0.0577 0.8165
SRP007169 PIK3R2 5296 RNAseq 0.4129 0.2771
SRP008496 PIK3R2 5296 RNAseq 0.6867 0.0375
SRP064894 PIK3R2 5296 RNAseq 0.2358 0.1653
SRP133303 PIK3R2 5296 RNAseq -0.4119 0.0042
SRP159526 PIK3R2 5296 RNAseq 0.0558 0.8091
SRP193095 PIK3R2 5296 RNAseq -0.1475 0.3189
SRP219564 PIK3R2 5296 RNAseq 0.6260 0.1302
TCGA PIK3R2 5296 RNAseq 0.0367 0.4607

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PIK3R2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PIK3R2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PIK3R2 5296 4 4 22
GSE20123 PIK3R2 5296 3 2 25
GSE43470 PIK3R2 5296 2 6 35
GSE46452 PIK3R2 5296 47 1 11
GSE47630 PIK3R2 5296 4 8 28
GSE54993 PIK3R2 5296 15 4 51
GSE54994 PIK3R2 5296 6 13 34
GSE60625 PIK3R2 5296 9 0 2
GSE74703 PIK3R2 5296 2 4 30
GSE74704 PIK3R2 5296 0 2 18
TCGA PIK3R2 5296 17 9 70

Total number of gains: 109; Total number of losses: 53; Total Number of normals: 326.  

 

Somatic mutations of PIK3R2:

 

Generating mutation plots.

 

Highly correlated genes for PIK3R2:

 

Showing top 20/159 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PIK3R2CYP11B20.730117404
PIK3R2HYOU10.679593303
PIK3R2GRM80.669286303
PIK3R2F110.647264404
PIK3R2ADAM320.641302303
PIK3R2SH3BP20.64088303
PIK3R2SLC45A30.636509303
PIK3R2MARVELD10.632372303
PIK3R2ANKRD20.626807303
PIK3R2OR2H20.622633403
PIK3R2KMT2B0.618422303
PIK3R2DGCR90.612379303
PIK3R2CABIN10.604568605
PIK3R2MOSPD30.60442604
PIK3R2RHBDD20.601914303
PIK3R2ATAT10.601063403
PIK3R2FOXB10.599622404
PIK3R2APOA40.599422403
PIK3R2RABEP20.596253403
PIK3R2ZNF5260.595719303

For details and further investigation, click here