| Full name: glutamate metabotropic receptor 8 | Alias Symbol: GLUR8|GPRC1H|mGlu8|MGLUR8 | ||
| Type: protein-coding gene | Cytoband: 7q31.33 | ||
| Entrez ID: 2918 | HGNC ID: HGNC:4600 | Ensembl Gene: ENSG00000179603 | OMIM ID: 601116 |
| Drug and gene relationship at DGIdb | |||
GRM8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04724 | Glutamatergic synapse |
Expression of GRM8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRM8 | 2918 | 216256_at | -0.0883 | 0.7131 | |
| GSE20347 | GRM8 | 2918 | 216256_at | -0.2202 | 0.0015 | |
| GSE23400 | GRM8 | 2918 | 216256_at | -0.0661 | 0.0144 | |
| GSE26886 | GRM8 | 2918 | 216256_at | 0.1052 | 0.2525 | |
| GSE29001 | GRM8 | 2918 | 216256_at | -0.2260 | 0.0952 | |
| GSE38129 | GRM8 | 2918 | 216256_at | -0.2097 | 0.0001 | |
| GSE45670 | GRM8 | 2918 | 216256_at | 0.0884 | 0.3204 | |
| GSE53622 | GRM8 | 2918 | 142284 | -0.2680 | 0.0248 | |
| GSE53624 | GRM8 | 2918 | 142284 | 0.4126 | 0.0001 | |
| GSE63941 | GRM8 | 2918 | 216256_at | 0.2614 | 0.1055 | |
| GSE77861 | GRM8 | 2918 | 216256_at | 0.0558 | 0.6059 | |
| SRP133303 | GRM8 | 2918 | RNAseq | 1.4282 | 0.0000 | |
| TCGA | GRM8 | 2918 | RNAseq | -0.5609 | 0.1273 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GRM8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRM8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRM8 | 2918 | 7 | 2 | 21 | |
| GSE20123 | GRM8 | 2918 | 7 | 2 | 21 | |
| GSE43470 | GRM8 | 2918 | 2 | 4 | 37 | |
| GSE46452 | GRM8 | 2918 | 7 | 2 | 50 | |
| GSE47630 | GRM8 | 2918 | 7 | 4 | 29 | |
| GSE54993 | GRM8 | 2918 | 3 | 5 | 62 | |
| GSE54994 | GRM8 | 2918 | 9 | 7 | 37 | |
| GSE60625 | GRM8 | 2918 | 0 | 0 | 11 | |
| GSE74703 | GRM8 | 2918 | 2 | 4 | 30 | |
| GSE74704 | GRM8 | 2918 | 5 | 2 | 13 | |
| TCGA | GRM8 | 2918 | 25 | 25 | 46 |
Total number of gains: 74; Total number of losses: 57; Total Number of normals: 357.
Somatic mutations of GRM8:
Generating mutation plots.
Highly correlated genes for GRM8:
Showing top 20/195 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRM8 | AHSP | 0.721705 | 4 | 0 | 4 |
| GRM8 | CTF1 | 0.712442 | 3 | 0 | 3 |
| GRM8 | LINC00598 | 0.679981 | 3 | 0 | 3 |
| GRM8 | GGA1 | 0.678538 | 3 | 0 | 3 |
| GRM8 | PIK3R2 | 0.669286 | 3 | 0 | 3 |
| GRM8 | NRGN | 0.667684 | 3 | 0 | 3 |
| GRM8 | EPO | 0.657931 | 5 | 0 | 4 |
| GRM8 | CSF2RA | 0.64309 | 3 | 0 | 3 |
| GRM8 | LINC01136 | 0.641362 | 5 | 0 | 4 |
| GRM8 | SMR3B | 0.638761 | 3 | 0 | 3 |
| GRM8 | RAX | 0.638364 | 6 | 0 | 5 |
| GRM8 | ZNRF4 | 0.638259 | 3 | 0 | 3 |
| GRM8 | BEST1 | 0.635127 | 3 | 0 | 3 |
| GRM8 | DGCR9 | 0.632274 | 4 | 0 | 3 |
| GRM8 | POU6F1 | 0.626838 | 3 | 0 | 3 |
| GRM8 | HSF4 | 0.625621 | 4 | 0 | 3 |
| GRM8 | ADAMTS10 | 0.624958 | 3 | 0 | 3 |
| GRM8 | TM4SF20 | 0.623136 | 4 | 0 | 3 |
| GRM8 | ALPK3 | 0.620609 | 3 | 0 | 3 |
| GRM8 | TRIM15 | 0.619508 | 6 | 0 | 5 |
For details and further investigation, click here
