Full name: TNF receptor associated factor 2	Alias Symbol: TRAP3|RNF117
Type: protein-coding gene	Cytoband: 9q34.3
Entrez ID: 7186	HGNC ID: HGNC:12032	Ensembl Gene: ENSG00000127191	OMIM ID: 601895
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 28/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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TRAF2 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04064	NF-kappa B signaling pathway	View
hsa04071	Sphingolipid signaling pathway	View
hsa04210	Apoptosis	View
hsa04380	Osteoclast differentiation	View
hsa04622	RIG-I-like receptor signaling pathway	View
hsa04668	TNF signaling pathway	View
hsa04920	Adipocytokine signaling pathway	View
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	View
hsa05160	Hepatitis C	View
hsa05168	Herpes simplex infection	View
hsa05169	Epstein-Barr virus infection	View
hsa05200	Pathways in cancer	View
hsa05222	Small cell lung cancer	View

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Expression of TRAF2:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	TRAF2	7186	204413_at	0.2508	0.3728	Show
GSE20347	TRAF2	7186	204413_at	0.1638	0.0741	Show
GSE23400	TRAF2	7186	204413_at	0.1400	0.0016	Show
GSE26886	TRAF2	7186	204413_at	0.3292	0.0478	Show
GSE29001	TRAF2	7186	204413_at	0.1747	0.4199	Show
GSE38129	TRAF2	7186	204413_at	0.2326	0.0013	Show
GSE45670	TRAF2	7186	204413_at	0.3313	0.0028	Show
GSE53622	TRAF2	7186	20878	0.5025	0.0000	Show
GSE53624	TRAF2	7186	20878	0.5350	0.0000	Show
GSE63941	TRAF2	7186	204413_at	0.8680	0.0040	Show
GSE77861	TRAF2	7186	204413_at	0.1066	0.4539	Show
GSE97050	TRAF2	7186	A_33_P3803639	0.3496	0.2576	Show
SRP007169	TRAF2	7186	RNAseq	-0.1141	0.8228	Show
SRP008496	TRAF2	7186	RNAseq	0.4057	0.3268	Show
SRP064894	TRAF2	7186	RNAseq	0.7396	0.0141	Show
SRP133303	TRAF2	7186	RNAseq	0.1638	0.3039	Show
SRP159526	TRAF2	7186	RNAseq	0.3257	0.4665	Show
SRP193095	TRAF2	7186	RNAseq	0.1250	0.2684	Show
SRP219564	TRAF2	7186	RNAseq	0.7392	0.0848	Show
TCGA	TRAF2	7186	RNAseq	0.2628	0.0002	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by TRAF2 expression:

 

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Copy number change of TRAF2:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	TRAF2	7186	5	7	18	Show
GSE20123	TRAF2	7186	5	7	18	Show
GSE43470	TRAF2	7186	3	7	33	Show
GSE46452	TRAF2	7186	6	13	40	Show
GSE47630	TRAF2	7186	6	15	19	Show
GSE54993	TRAF2	7186	3	3	64	Show
GSE54994	TRAF2	7186	12	8	33	Show
GSE60625	TRAF2	7186	0	0	11	Show
GSE74703	TRAF2	7186	3	5	28	Show
GSE74704	TRAF2	7186	3	5	12	Show
TCGA	TRAF2	7186	29	23	44	Show

Total number of gains: 75; Total number of losses: 93; Total Number of normals: 320.  Download Data

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Somatic mutations of TRAF2:

 

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Highly correlated genes for TRAF2:

 

Showing top 20/775 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
TRAF2	CRYBB2	0.789613	3	0	3
TRAF2	PPP1CA	0.749361	3	0	3
TRAF2	DGKH	0.723899	3	0	3
TRAF2	PTPN4	0.720299	3	0	3
TRAF2	PKNOX1	0.718299	3	0	3
TRAF2	MRPL38	0.697587	4	0	3
TRAF2	ARL6IP6	0.697405	3	0	3
TRAF2	NUSAP1	0.695324	5	0	4
TRAF2	ARF1	0.692071	4	0	3
TRAF2	GRIN3B	0.69147	3	0	3
TRAF2	WIPI2	0.68801	3	0	3
TRAF2	SNAPC2	0.687506	4	0	4
TRAF2	ZNF691	0.687505	4	0	4
TRAF2	NFKBIL1	0.686132	3	0	3
TRAF2	SEMG2	0.683873	4	0	3
TRAF2	OXCT2	0.683642	3	0	3
TRAF2	OGG1	0.683312	3	0	3
TRAF2	CDCA7	0.679338	4	0	3
TRAF2	MAST1	0.679061	3	0	3
TRAF2	PLD2	0.678703	3	0	3

For details and further investigation, click here