| Full name: paraoxonase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q21.3 | ||
| Entrez ID: 5446 | HGNC ID: HGNC:9206 | Ensembl Gene: ENSG00000105852 | OMIM ID: 602720 |
| Drug and gene relationship at DGIdb | |||
Expression of PON3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PON3 | 5446 | 213695_at | 1.1913 | 0.1257 | |
| GSE20347 | PON3 | 5446 | 213695_at | 0.3772 | 0.1035 | |
| GSE23400 | PON3 | 5446 | 213695_at | 0.0454 | 0.5277 | |
| GSE26886 | PON3 | 5446 | 213695_at | 1.2602 | 0.0096 | |
| GSE29001 | PON3 | 5446 | 213695_at | 0.4776 | 0.1889 | |
| GSE38129 | PON3 | 5446 | 213695_at | 0.4675 | 0.0716 | |
| GSE45670 | PON3 | 5446 | 213695_at | 0.4789 | 0.1776 | |
| GSE53622 | PON3 | 5446 | 79851 | 0.8661 | 0.0001 | |
| GSE53624 | PON3 | 5446 | 79851 | 0.9420 | 0.0000 | |
| GSE63941 | PON3 | 5446 | 213695_at | 2.1133 | 0.0878 | |
| GSE77861 | PON3 | 5446 | 213695_at | 0.7156 | 0.3377 | |
| GSE97050 | PON3 | 5446 | A_23_P215549 | 0.8538 | 0.2476 | |
| SRP133303 | PON3 | 5446 | RNAseq | 1.3959 | 0.0001 | |
| SRP159526 | PON3 | 5446 | RNAseq | 1.2111 | 0.0222 | |
| SRP219564 | PON3 | 5446 | RNAseq | 1.9265 | 0.0377 | |
| TCGA | PON3 | 5446 | RNAseq | 0.1385 | 0.7618 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by PON3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PON3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PON3 | 5446 | 13 | 0 | 17 | |
| GSE20123 | PON3 | 5446 | 13 | 0 | 17 | |
| GSE43470 | PON3 | 5446 | 7 | 1 | 35 | |
| GSE46452 | PON3 | 5446 | 12 | 0 | 47 | |
| GSE47630 | PON3 | 5446 | 8 | 2 | 30 | |
| GSE54993 | PON3 | 5446 | 1 | 9 | 60 | |
| GSE54994 | PON3 | 5446 | 16 | 2 | 35 | |
| GSE60625 | PON3 | 5446 | 0 | 5 | 6 | |
| GSE74703 | PON3 | 5446 | 6 | 1 | 29 | |
| GSE74704 | PON3 | 5446 | 9 | 0 | 11 | |
| TCGA | PON3 | 5446 | 56 | 4 | 36 |
Total number of gains: 141; Total number of losses: 24; Total Number of normals: 323.
Somatic mutations of PON3:
Generating mutation plots.
Highly correlated genes for PON3:
Showing top 20/175 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PON3 | WRN | 0.687432 | 4 | 0 | 4 |
| PON3 | RTTN | 0.686057 | 3 | 0 | 3 |
| PON3 | ETV4 | 0.685352 | 3 | 0 | 3 |
| PON3 | STK31 | 0.678407 | 3 | 0 | 3 |
| PON3 | BBS1 | 0.664097 | 3 | 0 | 3 |
| PON3 | EVA1A | 0.66384 | 3 | 0 | 3 |
| PON3 | GNPNAT1 | 0.653646 | 4 | 0 | 4 |
| PON3 | TIMM22 | 0.644412 | 3 | 0 | 3 |
| PON3 | BRDT | 0.643478 | 5 | 0 | 3 |
| PON3 | MND1 | 0.635552 | 4 | 0 | 3 |
| PON3 | LEMD1 | 0.635329 | 4 | 0 | 3 |
| PON3 | MUCL1 | 0.634294 | 5 | 0 | 5 |
| PON3 | PUS7 | 0.634042 | 5 | 0 | 4 |
| PON3 | RUVBL2 | 0.632683 | 4 | 0 | 3 |
| PON3 | MAGEA12 | 0.627995 | 5 | 0 | 3 |
| PON3 | CCDC34 | 0.623935 | 4 | 0 | 3 |
| PON3 | IGFBP4 | 0.620258 | 3 | 0 | 3 |
| PON3 | CTBP2 | 0.617042 | 3 | 0 | 3 |
| PON3 | C4orf46 | 0.61671 | 4 | 0 | 3 |
| PON3 | MAGEA4 | 0.6148 | 5 | 0 | 3 |
For details and further investigation, click here
