| Full name: ribosomal protein S6 kinase B2 | Alias Symbol: p70S6Kb|P70-BETA|STK14B|KLS|S6KB|S6Kbeta|S6Kβ | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 6199 | HGNC ID: HGNC:10437 | Ensembl Gene: ENSG00000175634 | OMIM ID: 608939 |
| Drug and gene relationship at DGIdb | |||
RPS6KB2 involved pathways:
Expression of RPS6KB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6KB2 | 6199 | 203777_s_at | 0.0148 | 0.9822 | |
| GSE20347 | RPS6KB2 | 6199 | 203777_s_at | -0.6068 | 0.0035 | |
| GSE23400 | RPS6KB2 | 6199 | 203777_s_at | -0.3483 | 0.0000 | |
| GSE26886 | RPS6KB2 | 6199 | 203777_s_at | -0.6844 | 0.0030 | |
| GSE29001 | RPS6KB2 | 6199 | 203777_s_at | -0.6185 | 0.0735 | |
| GSE38129 | RPS6KB2 | 6199 | 203777_s_at | -0.3380 | 0.1330 | |
| GSE45670 | RPS6KB2 | 6199 | 203777_s_at | -0.1071 | 0.5428 | |
| GSE53622 | RPS6KB2 | 6199 | 102864 | -0.7642 | 0.0000 | |
| GSE53624 | RPS6KB2 | 6199 | 102864 | -0.8664 | 0.0000 | |
| GSE63941 | RPS6KB2 | 6199 | 203777_s_at | 0.4610 | 0.3782 | |
| GSE77861 | RPS6KB2 | 6199 | 203777_s_at | -0.4002 | 0.0233 | |
| GSE97050 | RPS6KB2 | 6199 | A_33_P3230488 | 0.2116 | 0.5759 | |
| SRP007169 | RPS6KB2 | 6199 | RNAseq | -2.7952 | 0.0000 | |
| SRP008496 | RPS6KB2 | 6199 | RNAseq | -2.5140 | 0.0000 | |
| SRP064894 | RPS6KB2 | 6199 | RNAseq | -1.0203 | 0.0000 | |
| SRP133303 | RPS6KB2 | 6199 | RNAseq | -0.6589 | 0.0043 | |
| SRP159526 | RPS6KB2 | 6199 | RNAseq | -1.0049 | 0.0000 | |
| SRP193095 | RPS6KB2 | 6199 | RNAseq | -0.7990 | 0.0000 | |
| SRP219564 | RPS6KB2 | 6199 | RNAseq | -0.7252 | 0.0445 | |
| TCGA | RPS6KB2 | 6199 | RNAseq | 0.0131 | 0.8519 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RPS6KB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6KB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS6KB2 | 6199 | 10 | 3 | 17 | |
| GSE20123 | RPS6KB2 | 6199 | 10 | 3 | 17 | |
| GSE43470 | RPS6KB2 | 6199 | 5 | 1 | 37 | |
| GSE46452 | RPS6KB2 | 6199 | 14 | 3 | 42 | |
| GSE47630 | RPS6KB2 | 6199 | 8 | 5 | 27 | |
| GSE54993 | RPS6KB2 | 6199 | 3 | 1 | 66 | |
| GSE54994 | RPS6KB2 | 6199 | 13 | 4 | 36 | |
| GSE60625 | RPS6KB2 | 6199 | 0 | 3 | 8 | |
| GSE74703 | RPS6KB2 | 6199 | 4 | 0 | 32 | |
| GSE74704 | RPS6KB2 | 6199 | 8 | 1 | 11 | |
| TCGA | RPS6KB2 | 6199 | 29 | 8 | 59 |
Total number of gains: 104; Total number of losses: 32; Total Number of normals: 352.
Somatic mutations of RPS6KB2:
Generating mutation plots.
Highly correlated genes for RPS6KB2:
Showing top 20/796 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6KB2 | TMEM134 | 0.693485 | 13 | 0 | 12 |
| RPS6KB2 | C15orf48 | 0.67981 | 6 | 0 | 6 |
| RPS6KB2 | MVB12A | 0.678517 | 3 | 0 | 3 |
| RPS6KB2 | RHOD | 0.67557 | 13 | 0 | 11 |
| RPS6KB2 | PUSL1 | 0.665069 | 5 | 0 | 5 |
| RPS6KB2 | CNKSR1 | 0.661311 | 7 | 0 | 6 |
| RPS6KB2 | DHDDS | 0.658284 | 9 | 0 | 7 |
| RPS6KB2 | PTPRCAP | 0.654847 | 3 | 0 | 3 |
| RPS6KB2 | MYO1A | 0.653364 | 4 | 0 | 3 |
| RPS6KB2 | EML3 | 0.644678 | 12 | 0 | 11 |
| RPS6KB2 | CPTP | 0.644083 | 8 | 0 | 7 |
| RPS6KB2 | SP6 | 0.643107 | 4 | 0 | 3 |
| RPS6KB2 | PITHD1 | 0.641294 | 5 | 0 | 4 |
| RPS6KB2 | PRSS3 | 0.640425 | 10 | 0 | 9 |
| RPS6KB2 | AMFR | 0.639261 | 6 | 0 | 6 |
| RPS6KB2 | CTNNBIP1 | 0.637446 | 10 | 0 | 8 |
| RPS6KB2 | RABGGTA | 0.637173 | 9 | 0 | 7 |
| RPS6KB2 | KRT6C | 0.636884 | 3 | 0 | 3 |
| RPS6KB2 | NLRX1 | 0.635718 | 8 | 0 | 8 |
| RPS6KB2 | DHRS1 | 0.635337 | 12 | 0 | 9 |
For details and further investigation, click here
