WRN

 

Full name: WRN RecQ like helicase Alias Symbol: RECQL2|RECQ3
Type: protein-coding gene Cytoband: 8p12
Entrez ID: 7486 HGNC ID: HGNC:12791 Ensembl Gene: ENSG00000165392 OMIM ID: 604611
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of WRN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WRN 7486 205667_at 0.6683 0.1328
GSE20347 WRN 7486 205667_at 0.7066 0.0000
GSE23400 WRN 7486 205667_at 0.3678 0.0000
GSE26886 WRN 7486 205667_at 1.0080 0.0006
GSE29001 WRN 7486 205667_at 0.4642 0.0545
GSE38129 WRN 7486 205667_at 0.5846 0.0001
GSE45670 WRN 7486 205667_at 0.4122 0.0293
GSE53622 WRN 7486 53500 0.5139 0.0000
GSE53624 WRN 7486 53500 0.6084 0.0000
GSE63941 WRN 7486 205667_at 0.2412 0.6360
GSE77861 WRN 7486 205667_at 0.5052 0.0785
GSE97050 WRN 7486 A_23_P250813 0.6675 0.1716
SRP007169 WRN 7486 RNAseq 1.0401 0.0111
SRP008496 WRN 7486 RNAseq 0.9209 0.0010
SRP064894 WRN 7486 RNAseq 0.0596 0.7817
SRP133303 WRN 7486 RNAseq 0.0131 0.9394
SRP159526 WRN 7486 RNAseq 0.3069 0.3738
SRP193095 WRN 7486 RNAseq 0.4180 0.0003
SRP219564 WRN 7486 RNAseq 0.2718 0.2626
TCGA WRN 7486 RNAseq -0.0072 0.9122

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by WRN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WRN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WRN 7486 4 11 15
GSE20123 WRN 7486 4 11 15
GSE43470 WRN 7486 4 7 32
GSE46452 WRN 7486 13 13 33
GSE47630 WRN 7486 10 8 22
GSE54993 WRN 7486 2 15 53
GSE54994 WRN 7486 11 15 27
GSE60625 WRN 7486 3 0 8
GSE74703 WRN 7486 4 6 26
GSE74704 WRN 7486 3 7 10
TCGA WRN 7486 19 40 37

Total number of gains: 77; Total number of losses: 133; Total Number of normals: 278.  

 

Somatic mutations of WRN:

 

Generating mutation plots.

 

Highly correlated genes for WRN:

 

Showing top 20/1489 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WRNEME10.751638505
WRNCDCA20.738335606
WRNMAK160.73640212012
WRNISY10.725717303
WRNTMEM650.713803303
WRNUBE2J20.712962303
WRNSNAP470.712816303
WRNDBF40.71241909
WRNNAA380.704829303
WRNLRRC580.69972505
WRNFIGNL10.692324504
WRNPBK0.6885021209
WRNCENPBD10.687661404
WRNPON30.687432404
WRNCEP550.680027909
WRNPUS70.67865111010
WRNCXCL30.676131403
WRNMETTL230.674128505
WRNFAF20.673528303
WRNASPM0.67248710010

For details and further investigation, click here