| Full name: POU class 2 homeobox 3 | Alias Symbol: OCT11|PLA-1|Skn-1a|Epoc-1 | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 25833 | HGNC ID: HGNC:19864 | Ensembl Gene: ENSG00000137709 | OMIM ID: 607394 |
| Drug and gene relationship at DGIdb | |||
POU2F3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of POU2F3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POU2F3 | 25833 | 207109_at | -0.0893 | 0.8942 | |
| GSE20347 | POU2F3 | 25833 | 207109_at | -0.0499 | 0.8137 | |
| GSE23400 | POU2F3 | 25833 | 215355_at | -0.0904 | 0.0000 | |
| GSE26886 | POU2F3 | 25833 | 207109_at | 0.1835 | 0.5752 | |
| GSE29001 | POU2F3 | 25833 | 207109_at | -0.1939 | 0.7948 | |
| GSE38129 | POU2F3 | 25833 | 207109_at | 0.0821 | 0.6372 | |
| GSE45670 | POU2F3 | 25833 | 207109_at | 0.6926 | 0.0554 | |
| GSE53622 | POU2F3 | 25833 | 65069 | -0.3599 | 0.0247 | |
| GSE53624 | POU2F3 | 25833 | 65069 | -0.4751 | 0.0017 | |
| GSE63941 | POU2F3 | 25833 | 207109_at | 0.5012 | 0.2101 | |
| GSE77861 | POU2F3 | 25833 | 207109_at | 0.1249 | 0.4188 | |
| SRP007169 | POU2F3 | 25833 | RNAseq | -1.9220 | 0.0011 | |
| SRP064894 | POU2F3 | 25833 | RNAseq | -1.0048 | 0.0044 | |
| SRP133303 | POU2F3 | 25833 | RNAseq | -0.4738 | 0.0766 | |
| SRP159526 | POU2F3 | 25833 | RNAseq | -0.1582 | 0.8403 | |
| SRP193095 | POU2F3 | 25833 | RNAseq | -0.4215 | 0.0334 | |
| SRP219564 | POU2F3 | 25833 | RNAseq | -0.8256 | 0.1744 | |
| TCGA | POU2F3 | 25833 | RNAseq | 0.6735 | 0.0118 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by POU2F3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POU2F3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU2F3 | 25833 | 1 | 12 | 17 | |
| GSE20123 | POU2F3 | 25833 | 1 | 12 | 17 | |
| GSE43470 | POU2F3 | 25833 | 2 | 8 | 33 | |
| GSE46452 | POU2F3 | 25833 | 3 | 26 | 30 | |
| GSE47630 | POU2F3 | 25833 | 2 | 19 | 19 | |
| GSE54993 | POU2F3 | 25833 | 10 | 0 | 60 | |
| GSE54994 | POU2F3 | 25833 | 5 | 19 | 29 | |
| GSE60625 | POU2F3 | 25833 | 0 | 3 | 8 | |
| GSE74703 | POU2F3 | 25833 | 1 | 5 | 30 | |
| GSE74704 | POU2F3 | 25833 | 0 | 8 | 12 | |
| TCGA | POU2F3 | 25833 | 5 | 50 | 41 |
Total number of gains: 30; Total number of losses: 162; Total Number of normals: 296.
Somatic mutations of POU2F3:
Generating mutation plots.
Highly correlated genes for POU2F3:
Showing top 20/35 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU2F3 | MSMB | 0.672961 | 3 | 0 | 3 |
| POU2F3 | CERS4 | 0.621825 | 4 | 0 | 3 |
| POU2F3 | TMEM79 | 0.615333 | 4 | 0 | 3 |
| POU2F3 | SCO2 | 0.614373 | 4 | 0 | 3 |
| POU2F3 | ZNF839 | 0.609501 | 3 | 0 | 3 |
| POU2F3 | SMCR5 | 0.58717 | 3 | 0 | 3 |
| POU2F3 | GSTA3 | 0.586798 | 5 | 0 | 4 |
| POU2F3 | SLC35E1 | 0.585393 | 3 | 0 | 3 |
| POU2F3 | TMPRSS13 | 0.583586 | 6 | 0 | 4 |
| POU2F3 | PLEKHN1 | 0.582071 | 3 | 0 | 3 |
| POU2F3 | SYNGR1 | 0.557158 | 3 | 0 | 3 |
| POU2F3 | AACS | 0.553259 | 4 | 0 | 3 |
| POU2F3 | TTN-AS1 | 0.549529 | 3 | 0 | 3 |
| POU2F3 | SGPP2 | 0.547715 | 5 | 0 | 4 |
| POU2F3 | CDC42BPG | 0.538852 | 3 | 0 | 3 |
| POU2F3 | MAPKAPK3 | 0.53825 | 4 | 0 | 3 |
| POU2F3 | PRKCD | 0.53655 | 4 | 0 | 3 |
| POU2F3 | OSBPL2 | 0.535444 | 5 | 0 | 4 |
| POU2F3 | PPP2R1B | 0.534079 | 3 | 0 | 3 |
| POU2F3 | MASP2 | 0.532898 | 3 | 0 | 3 |
For details and further investigation, click here
