| Full name: SCO cytochrome c oxidase assembly protein 2 | Alias Symbol: SCO1L | ||
| Type: protein-coding gene | Cytoband: 22q13.33 | ||
| Entrez ID: 9997 | HGNC ID: HGNC:10604 | Ensembl Gene: ENSG00000130489 | OMIM ID: 604272 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SCO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCO2 | 9997 | 205241_at | 0.4561 | 0.5436 | |
| GSE20347 | SCO2 | 9997 | 205241_at | 0.1325 | 0.6949 | |
| GSE23400 | SCO2 | 9997 | 205241_at | 0.7898 | 0.0000 | |
| GSE26886 | SCO2 | 9997 | 205241_at | 0.2157 | 0.4889 | |
| GSE29001 | SCO2 | 9997 | 205241_at | 0.7738 | 0.0161 | |
| GSE38129 | SCO2 | 9997 | 205241_at | 0.3581 | 0.1408 | |
| GSE45670 | SCO2 | 9997 | 205241_at | 1.3264 | 0.0000 | |
| GSE63941 | SCO2 | 9997 | 205241_at | -0.5196 | 0.4310 | |
| GSE77861 | SCO2 | 9997 | 205241_at | 0.2546 | 0.2125 | |
| GSE97050 | SCO2 | 9997 | A_23_P132388 | 0.7082 | 0.1961 | |
| SRP007169 | SCO2 | 9997 | RNAseq | -3.4107 | 0.0000 | |
| SRP064894 | SCO2 | 9997 | RNAseq | 1.5236 | 0.0000 | |
| SRP133303 | SCO2 | 9997 | RNAseq | 0.4483 | 0.1847 | |
| SRP159526 | SCO2 | 9997 | RNAseq | -0.2495 | 0.5810 | |
| SRP193095 | SCO2 | 9997 | RNAseq | 0.2083 | 0.3423 | |
| SRP219564 | SCO2 | 9997 | RNAseq | 1.0675 | 0.0449 | |
| TCGA | SCO2 | 9997 | RNAseq | 0.4507 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by SCO2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SCO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCO2 | 9997 | 3 | 8 | 19 | |
| GSE20123 | SCO2 | 9997 | 3 | 8 | 19 | |
| GSE43470 | SCO2 | 9997 | 2 | 8 | 33 | |
| GSE46452 | SCO2 | 9997 | 31 | 2 | 26 | |
| GSE47630 | SCO2 | 9997 | 9 | 4 | 27 | |
| GSE54993 | SCO2 | 9997 | 4 | 6 | 60 | |
| GSE54994 | SCO2 | 9997 | 11 | 8 | 34 | |
| GSE60625 | SCO2 | 9997 | 5 | 0 | 6 | |
| GSE74703 | SCO2 | 9997 | 2 | 6 | 28 | |
| GSE74704 | SCO2 | 9997 | 1 | 4 | 15 | |
| TCGA | SCO2 | 9997 | 26 | 16 | 54 |
Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.
Somatic mutations of SCO2:
Generating mutation plots.
Highly correlated genes for SCO2:
Showing top 20/489 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCO2 | TYMP | 0.767744 | 9 | 0 | 9 |
| SCO2 | FBXO6 | 0.759185 | 3 | 0 | 3 |
| SCO2 | OCIAD2 | 0.731278 | 3 | 0 | 3 |
| SCO2 | PARP12 | 0.724776 | 6 | 0 | 6 |
| SCO2 | CENPW | 0.724465 | 3 | 0 | 3 |
| SCO2 | DTX3L | 0.71428 | 3 | 0 | 3 |
| SCO2 | GPR153 | 0.702548 | 4 | 0 | 4 |
| SCO2 | MASTL | 0.697186 | 3 | 0 | 3 |
| SCO2 | TTC39C | 0.694618 | 3 | 0 | 3 |
| SCO2 | RNF187 | 0.694481 | 3 | 0 | 3 |
| SCO2 | AGTRAP | 0.688884 | 4 | 0 | 4 |
| SCO2 | GEN1 | 0.677259 | 3 | 0 | 3 |
| SCO2 | TBX1 | 0.673443 | 3 | 0 | 3 |
| SCO2 | TAP1 | 0.670165 | 10 | 0 | 9 |
| SCO2 | RPS6KB1 | 0.667701 | 3 | 0 | 3 |
| SCO2 | OAS2 | 0.667678 | 8 | 0 | 7 |
| SCO2 | MMP9 | 0.667505 | 4 | 0 | 4 |
| SCO2 | AGFG1 | 0.666044 | 3 | 0 | 3 |
| SCO2 | LSM5 | 0.663624 | 4 | 0 | 3 |
| SCO2 | SLC2A9 | 0.662721 | 4 | 0 | 4 |
For details and further investigation, click here
