| Full name: POU class 6 homeobox 2 | Alias Symbol: RPF-1 | ||
| Type: protein-coding gene | Cytoband: 7p14.1 | ||
| Entrez ID: 11281 | HGNC ID: HGNC:21694 | Ensembl Gene: ENSG00000106536 | OMIM ID: 609062 |
| Drug and gene relationship at DGIdb | |||
Expression of POU6F2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POU6F2 | 11281 | 207450_s_at | 0.2872 | 0.2812 | |
| GSE20347 | POU6F2 | 11281 | 207450_s_at | 0.0691 | 0.2385 | |
| GSE23400 | POU6F2 | 11281 | 207450_s_at | -0.1005 | 0.0088 | |
| GSE26886 | POU6F2 | 11281 | 207450_s_at | 0.4760 | 0.0026 | |
| GSE29001 | POU6F2 | 11281 | 207450_s_at | 0.0413 | 0.6927 | |
| GSE38129 | POU6F2 | 11281 | 207450_s_at | 0.1282 | 0.0832 | |
| GSE45670 | POU6F2 | 11281 | 207450_s_at | 0.2985 | 0.0040 | |
| GSE53622 | POU6F2 | 11281 | 93 | 2.1759 | 0.0000 | |
| GSE53624 | POU6F2 | 11281 | 93 | 2.6388 | 0.0000 | |
| GSE63941 | POU6F2 | 11281 | 207450_s_at | 0.4261 | 0.0455 | |
| GSE77861 | POU6F2 | 11281 | 207450_s_at | 0.0119 | 0.9209 | |
| GSE97050 | POU6F2 | 11281 | A_23_P147900 | 0.7995 | 0.3719 | |
| SRP133303 | POU6F2 | 11281 | RNAseq | 3.6699 | 0.0000 | |
| SRP159526 | POU6F2 | 11281 | RNAseq | 4.1036 | 0.0000 | |
| TCGA | POU6F2 | 11281 | RNAseq | 2.9199 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by POU6F2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POU6F2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU6F2 | 11281 | 15 | 0 | 15 | |
| GSE20123 | POU6F2 | 11281 | 14 | 0 | 16 | |
| GSE43470 | POU6F2 | 11281 | 4 | 0 | 39 | |
| GSE46452 | POU6F2 | 11281 | 11 | 1 | 47 | |
| GSE47630 | POU6F2 | 11281 | 8 | 1 | 31 | |
| GSE54993 | POU6F2 | 11281 | 0 | 7 | 63 | |
| GSE54994 | POU6F2 | 11281 | 18 | 3 | 32 | |
| GSE60625 | POU6F2 | 11281 | 0 | 0 | 11 | |
| GSE74703 | POU6F2 | 11281 | 4 | 0 | 32 | |
| GSE74704 | POU6F2 | 11281 | 8 | 0 | 12 | |
| TCGA | POU6F2 | 11281 | 52 | 8 | 36 |
Total number of gains: 134; Total number of losses: 20; Total Number of normals: 334.
Somatic mutations of POU6F2:
Generating mutation plots.
Highly correlated genes for POU6F2:
Showing top 20/248 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU6F2 | GJA3 | 0.733585 | 3 | 0 | 3 |
| POU6F2 | POU6F2-AS2 | 0.692077 | 6 | 0 | 6 |
| POU6F2 | VSIG1 | 0.660287 | 3 | 0 | 3 |
| POU6F2 | ANGPT2 | 0.654713 | 3 | 0 | 3 |
| POU6F2 | WDR72 | 0.631477 | 6 | 0 | 5 |
| POU6F2 | SIX1 | 0.630125 | 3 | 0 | 3 |
| POU6F2 | SPRR2G | 0.629896 | 3 | 0 | 3 |
| POU6F2 | ANKRD53 | 0.626192 | 3 | 0 | 3 |
| POU6F2 | TSPO2 | 0.625351 | 3 | 0 | 3 |
| POU6F2 | MAGEA4 | 0.622304 | 4 | 0 | 3 |
| POU6F2 | GDPD2 | 0.617945 | 4 | 0 | 3 |
| POU6F2 | SOX11 | 0.616745 | 4 | 0 | 3 |
| POU6F2 | FABP4 | 0.612253 | 3 | 0 | 3 |
| POU6F2 | DLX6 | 0.60668 | 4 | 0 | 3 |
| POU6F2 | INO80B | 0.605916 | 4 | 0 | 4 |
| POU6F2 | FMNL2 | 0.605157 | 4 | 0 | 3 |
| POU6F2 | WFDC5 | 0.604365 | 4 | 0 | 3 |
| POU6F2 | DHRS13 | 0.60279 | 5 | 0 | 5 |
| POU6F2 | COL27A1 | 0.602443 | 3 | 0 | 3 |
| POU6F2 | HOXC9 | 0.601953 | 3 | 0 | 3 |
For details and further investigation, click here
