| Full name: protein phosphatase 1 regulatory inhibitor subunit 1A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 5502 | HGNC ID: HGNC:9286 | Ensembl Gene: ENSG00000135447 | OMIM ID: 613246 |
| Drug and gene relationship at DGIdb | |||
PPP1R1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04720 | Long-term potentiation |
Expression of PPP1R1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R1A | 5502 | 205478_at | -1.0640 | 0.2795 | |
| GSE20347 | PPP1R1A | 5502 | 205478_at | -0.3533 | 0.0085 | |
| GSE23400 | PPP1R1A | 5502 | 205478_at | -0.8033 | 0.0000 | |
| GSE26886 | PPP1R1A | 5502 | 235129_at | -0.0643 | 0.6816 | |
| GSE29001 | PPP1R1A | 5502 | 205478_at | -0.3513 | 0.0074 | |
| GSE38129 | PPP1R1A | 5502 | 205478_at | -1.2889 | 0.0001 | |
| GSE45670 | PPP1R1A | 5502 | 205478_at | -0.5742 | 0.0000 | |
| GSE53622 | PPP1R1A | 5502 | 90516 | -0.3927 | 0.0043 | |
| GSE53624 | PPP1R1A | 5502 | 90516 | 0.0833 | 0.6659 | |
| GSE63941 | PPP1R1A | 5502 | 205478_at | 0.3764 | 0.3114 | |
| GSE77861 | PPP1R1A | 5502 | 235129_at | -0.1964 | 0.1540 | |
| GSE97050 | PPP1R1A | 5502 | A_24_P13285 | -0.2444 | 0.6107 | |
| SRP133303 | PPP1R1A | 5502 | RNAseq | -1.6657 | 0.1550 | |
| SRP159526 | PPP1R1A | 5502 | RNAseq | -2.7574 | 0.0001 | |
| SRP219564 | PPP1R1A | 5502 | RNAseq | -3.0147 | 0.0280 | |
| TCGA | PPP1R1A | 5502 | RNAseq | -3.4623 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PPP1R1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R1A | 5502 | 4 | 1 | 25 | |
| GSE20123 | PPP1R1A | 5502 | 4 | 1 | 25 | |
| GSE43470 | PPP1R1A | 5502 | 5 | 0 | 38 | |
| GSE46452 | PPP1R1A | 5502 | 7 | 1 | 51 | |
| GSE47630 | PPP1R1A | 5502 | 10 | 2 | 28 | |
| GSE54993 | PPP1R1A | 5502 | 0 | 5 | 65 | |
| GSE54994 | PPP1R1A | 5502 | 4 | 1 | 48 | |
| GSE60625 | PPP1R1A | 5502 | 0 | 0 | 11 | |
| GSE74703 | PPP1R1A | 5502 | 4 | 0 | 32 | |
| GSE74704 | PPP1R1A | 5502 | 3 | 1 | 16 | |
| TCGA | PPP1R1A | 5502 | 16 | 11 | 69 |
Total number of gains: 57; Total number of losses: 23; Total Number of normals: 408.
Somatic mutations of PPP1R1A:
Generating mutation plots.
Highly correlated genes for PPP1R1A:
Showing top 20/488 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R1A | ANGPTL1 | 0.747676 | 3 | 0 | 3 |
| PPP1R1A | HPSE2 | 0.740293 | 7 | 0 | 7 |
| PPP1R1A | LINC00472 | 0.735312 | 4 | 0 | 4 |
| PPP1R1A | OGN | 0.727818 | 5 | 0 | 5 |
| PPP1R1A | FXYD1 | 0.726166 | 7 | 0 | 7 |
| PPP1R1A | MYOM1 | 0.712117 | 8 | 0 | 6 |
| PPP1R1A | EIF4E3 | 0.704869 | 3 | 0 | 3 |
| PPP1R1A | GSC | 0.702818 | 3 | 0 | 3 |
| PPP1R1A | TMOD1 | 0.702099 | 6 | 0 | 5 |
| PPP1R1A | ATP1A2 | 0.693814 | 7 | 0 | 6 |
| PPP1R1A | GADL1 | 0.693811 | 4 | 0 | 4 |
| PPP1R1A | CKMT2 | 0.683441 | 9 | 0 | 7 |
| PPP1R1A | ADAMTS8 | 0.679963 | 5 | 0 | 5 |
| PPP1R1A | PDZRN4 | 0.679315 | 7 | 0 | 6 |
| PPP1R1A | HSPB2 | 0.675361 | 7 | 0 | 5 |
| PPP1R1A | KCNMA1 | 0.674038 | 6 | 0 | 5 |
| PPP1R1A | ABCA8 | 0.672791 | 6 | 0 | 5 |
| PPP1R1A | CASQ2 | 0.670612 | 8 | 0 | 6 |
| PPP1R1A | KCNA5 | 0.670181 | 8 | 0 | 7 |
| PPP1R1A | LINC01282 | 0.664671 | 3 | 0 | 3 |
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