PRIMPOL

 

Full name: primase and DNA directed polymerase Alias Symbol: FLJ33167
Type: protein-coding gene Cytoband: 4q35.1
Entrez ID: 201973 HGNC ID: HGNC:26575 Ensembl Gene: ENSG00000164306 OMIM ID: 615421
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PRIMPOL:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRIMPOL 201973 227157_at -0.3400 0.3803
GSE26886 PRIMPOL 201973 227157_at -0.2793 0.4765
GSE45670 PRIMPOL 201973 227157_at -0.2523 0.1356
GSE53622 PRIMPOL 201973 77714 0.1114 0.1916
GSE53624 PRIMPOL 201973 77714 0.0862 0.3156
GSE63941 PRIMPOL 201973 227157_at -0.1348 0.8040
GSE77861 PRIMPOL 201973 227157_at 0.0517 0.8563
SRP007169 PRIMPOL 201973 RNAseq -0.3214 0.5090
SRP008496 PRIMPOL 201973 RNAseq 0.0243 0.9406
SRP064894 PRIMPOL 201973 RNAseq -0.0788 0.6165
SRP133303 PRIMPOL 201973 RNAseq 0.3826 0.1503
SRP159526 PRIMPOL 201973 RNAseq 0.3430 0.1513
SRP193095 PRIMPOL 201973 RNAseq 0.0869 0.5044
SRP219564 PRIMPOL 201973 RNAseq -0.6784 0.1953

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by PRIMPOL expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  


Copy number change of PRIMPOL:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRIMPOL 201973 3 13 14
GSE20123 PRIMPOL 201973 3 13 14
GSE43470 PRIMPOL 201973 1 12 30
GSE46452 PRIMPOL 201973 1 36 22
GSE47630 PRIMPOL 201973 0 22 18
GSE54993 PRIMPOL 201973 10 0 60
GSE54994 PRIMPOL 201973 2 12 39
GSE60625 PRIMPOL 201973 0 0 11
GSE74703 PRIMPOL 201973 1 9 26
GSE74704 PRIMPOL 201973 1 6 13

Total number of gains: 22; Total number of losses: 123; Total Number of normals: 247.  


 

Somatic mutations of PRIMPOL:

 

Generating mutation plots.

 

Highly correlated genes for PRIMPOL:

 

Showing top 20/67 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRIMPOLSMARCA20.690046303
PRIMPOLDET10.681473303
PRIMPOLKIAA11070.653044303
PRIMPOLXPO40.651996303
PRIMPOLTTC170.638908303
PRIMPOLPDK30.636869303
PRIMPOLDOCK80.630084303
PRIMPOLTTC280.623383303
PRIMPOLSETDB20.6169404
PRIMPOLRNF380.613358303
PRIMPOLTSHZ10.612222303
PRIMPOLFGFR1OP20.606164303
PRIMPOLWNT5B0.605893303
PRIMPOLSMIM200.601948403
PRIMPOLPIGB0.592971303
PRIMPOLPARVA0.592011403
PRIMPOLCGGBP10.590062403
PRIMPOLAKAP110.588198403
PRIMPOLN4BP2L20.587514303
PRIMPOLCREBL20.587345504

For details and further investigation, click here