MYD88

 

Full name: MYD88 innate immune signal transduction adaptor Alias Symbol: 
Type: protein-coding gene Cytoband: 3p22.2
Entrez ID: 4615 HGNC ID: HGNC:7562 Ensembl Gene: ENSG00000172936 OMIM ID: 602170
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MYD88 involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05132Salmonella infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection

 

Expression of MYD88:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MYD88 4615 209124_at 0.1691 0.7982
GSE20347 MYD88 4615 209124_at -0.8414 0.0000
GSE23400 MYD88 4615 209124_at -0.4410 0.0000
GSE26886 MYD88 4615 209124_at -1.3781 0.0000
GSE29001 MYD88 4615 209124_at -0.6815 0.0002
GSE38129 MYD88 4615 209124_at -0.6260 0.0008
GSE45670 MYD88 4615 209124_at 0.1290 0.4178
GSE53622 MYD88 4615 9455 -0.2750 0.0036
GSE53624 MYD88 4615 9455 -0.6601 0.0000
GSE63941 MYD88 4615 209124_at -0.6094 0.3711
GSE77861 MYD88 4615 209124_at -0.5512 0.0420
GSE97050 MYD88 4615 A_23_P362659 0.4569 0.3291
SRP007169 MYD88 4615 RNAseq -1.8008 0.0000
SRP008496 MYD88 4615 RNAseq -1.7263 0.0000
SRP064894 MYD88 4615 RNAseq -0.5851 0.0002
SRP133303 MYD88 4615 RNAseq -0.5336 0.0112
SRP159526 MYD88 4615 RNAseq -1.2640 0.0001
SRP193095 MYD88 4615 RNAseq -1.0799 0.0000
SRP219564 MYD88 4615 RNAseq -1.0373 0.0186
TCGA MYD88 4615 RNAseq 0.0593 0.3247

Upregulated datasets: 0; Downregulated datasets: 6.  

 

Survival by MYD88 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MYD88:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MYD88 4615 0 19 11
GSE20123 MYD88 4615 0 19 11
GSE43470 MYD88 4615 0 20 23
GSE46452 MYD88 4615 2 17 40
GSE47630 MYD88 4615 1 25 14
GSE54993 MYD88 4615 6 3 61
GSE54994 MYD88 4615 1 33 19
GSE60625 MYD88 4615 5 0 6
GSE74703 MYD88 4615 0 16 20
GSE74704 MYD88 4615 0 13 7
TCGA MYD88 4615 1 71 24

Total number of gains: 16; Total number of losses: 236; Total Number of normals: 236.  

 

Somatic mutations of MYD88:

 

Generating mutation plots.

 

Highly correlated genes for MYD88:

 

Showing top 20/1254 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MYD88ACAA10.75597510010
MYD88SULT2B10.734317706
MYD88ACTR3C0.731194303
MYD88TMEM2200.73072303
MYD88ELOVL10.730028404
MYD88PRADC10.728202303
MYD88ZNF8440.719717303
MYD88RAB420.719305303
MYD88PPL0.717088808
MYD88TOM10.711281009
MYD88EVPL0.708965908
MYD88ACTR30.708373606
MYD88TRIP100.705287909
MYD88PRMT20.703221504
MYD88EPS8L10.702573908
MYD88SH3GL10.7021951009
MYD88PDLIM20.701656707
MYD88MXD10.699548909
MYD88ASCC20.69754410010
MYD88VPS37B0.696944909

For details and further investigation, click here