PRKD1

 

Full name: protein kinase D1 Alias Symbol: PKCM|PKD|PKC-mu
Type: protein-coding gene Cytoband: 14q12
Entrez ID: 5587 HGNC ID: HGNC:9407 Ensembl Gene: ENSG00000184304 OMIM ID: 605435
Drug and gene relationship at DGIdb

 

PRKD1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04925Aldosterone synthesis and secretion

 

Expression of PRKD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKD1 5587 205880_at -0.6214 0.5155
GSE20347 PRKD1 5587 205880_at 0.2113 0.0567
GSE23400 PRKD1 5587 205880_at 0.1993 0.0131
GSE26886 PRKD1 5587 205880_at 1.5379 0.0081
GSE29001 PRKD1 5587 205880_at 0.1963 0.6474
GSE38129 PRKD1 5587 205880_at 0.2689 0.4159
GSE45670 PRKD1 5587 205880_at -1.3988 0.0009
GSE53622 PRKD1 5587 6766 0.3163 0.0317
GSE53624 PRKD1 5587 6766 0.4227 0.0016
GSE63941 PRKD1 5587 205880_at -3.6826 0.0155
GSE77861 PRKD1 5587 205880_at 0.1023 0.5428
GSE97050 PRKD1 5587 A_23_P106016 0.0147 0.9626
SRP007169 PRKD1 5587 RNAseq 3.0238 0.0004
SRP008496 PRKD1 5587 RNAseq 4.0299 0.0000
SRP064894 PRKD1 5587 RNAseq 0.8862 0.0031
SRP133303 PRKD1 5587 RNAseq 0.6623 0.0061
SRP159526 PRKD1 5587 RNAseq 1.2426 0.0202
SRP219564 PRKD1 5587 RNAseq 0.2049 0.7975
TCGA PRKD1 5587 RNAseq -0.2991 0.1498

Upregulated datasets: 4; Downregulated datasets: 2.  

 

Survival by PRKD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKD1 5587 9 4 17
GSE20123 PRKD1 5587 9 4 17
GSE43470 PRKD1 5587 8 2 33
GSE46452 PRKD1 5587 16 2 41
GSE47630 PRKD1 5587 11 10 19
GSE54993 PRKD1 5587 3 11 56
GSE54994 PRKD1 5587 19 5 29
GSE60625 PRKD1 5587 0 2 9
GSE74703 PRKD1 5587 7 2 27
GSE74704 PRKD1 5587 3 3 14
TCGA PRKD1 5587 33 15 48

Total number of gains: 118; Total number of losses: 60; Total Number of normals: 310.  

 

Somatic mutations of PRKD1:

 

Generating mutation plots.

 

Highly correlated genes for PRKD1:

 

Showing top 20/1026 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKD1SPATA90.717387303
PRKD1DCHS10.706724909
PRKD1AFF30.705613303
PRKD1SMAD90.704555707
PRKD1TMEM178A0.702627404
PRKD1CASQ20.700428404
PRKD1RASSF80.696415706
PRKD1DNAJC80.693188404
PRKD1SDC20.687792908
PRKD1ARHGEF90.684061403
PRKD1SCN3A0.683841303
PRKD1BICC10.683073909
PRKD1RASL11A0.68295303
PRKD1SLITRK60.6789303
PRKD1ANXA60.67884711011
PRKD1CLEC14A0.675787404
PRKD1USP510.67477303
PRKD1MPDZ0.67144411010
PRKD1C70.669725404
PRKD1ARHGAP60.669456605

For details and further investigation, click here