| Full name: spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP | Alias Symbol: Ara1|Snu66|SNRNP110|HAF | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 9092 | HGNC ID: HGNC:10538 | Ensembl Gene: ENSG00000175467 | OMIM ID: 605941 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SART1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SART1 | 9092 | 200051_at | 0.3219 | 0.4729 | |
| GSE20347 | SART1 | 9092 | 200051_at | 0.0741 | 0.6778 | |
| GSE23400 | SART1 | 9092 | 200051_at | 0.3096 | 0.0000 | |
| GSE26886 | SART1 | 9092 | 200051_at | 1.0234 | 0.0000 | |
| GSE29001 | SART1 | 9092 | 200051_at | 0.3785 | 0.1501 | |
| GSE38129 | SART1 | 9092 | 200051_at | 0.1409 | 0.2019 | |
| GSE45670 | SART1 | 9092 | 200051_at | 0.2714 | 0.0847 | |
| GSE53622 | SART1 | 9092 | 27791 | 0.1471 | 0.0837 | |
| GSE53624 | SART1 | 9092 | 27791 | 0.4413 | 0.0000 | |
| GSE63941 | SART1 | 9092 | 200051_at | 0.6276 | 0.0632 | |
| GSE77861 | SART1 | 9092 | 200051_at | 0.5113 | 0.0029 | |
| GSE97050 | SART1 | 9092 | A_33_P3299435 | 0.0571 | 0.7982 | |
| SRP007169 | SART1 | 9092 | RNAseq | 1.5472 | 0.0246 | |
| SRP008496 | SART1 | 9092 | RNAseq | 1.8785 | 0.0010 | |
| SRP064894 | SART1 | 9092 | RNAseq | 0.5127 | 0.0089 | |
| SRP133303 | SART1 | 9092 | RNAseq | 0.5180 | 0.0320 | |
| SRP159526 | SART1 | 9092 | RNAseq | 0.4662 | 0.0278 | |
| SRP193095 | SART1 | 9092 | RNAseq | 0.5117 | 0.0000 | |
| SRP219564 | SART1 | 9092 | RNAseq | 0.4291 | 0.1711 | |
| TCGA | SART1 | 9092 | RNAseq | 0.1365 | 0.0036 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SART1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SART1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SART1 | 9092 | 8 | 5 | 17 | |
| GSE20123 | SART1 | 9092 | 8 | 5 | 17 | |
| GSE43470 | SART1 | 9092 | 6 | 1 | 36 | |
| GSE46452 | SART1 | 9092 | 11 | 3 | 45 | |
| GSE47630 | SART1 | 9092 | 7 | 5 | 28 | |
| GSE54993 | SART1 | 9092 | 3 | 0 | 67 | |
| GSE54994 | SART1 | 9092 | 8 | 5 | 40 | |
| GSE60625 | SART1 | 9092 | 0 | 3 | 8 | |
| GSE74703 | SART1 | 9092 | 4 | 0 | 32 | |
| GSE74704 | SART1 | 9092 | 6 | 3 | 11 | |
| TCGA | SART1 | 9092 | 24 | 6 | 66 |
Total number of gains: 85; Total number of losses: 36; Total Number of normals: 367.
Somatic mutations of SART1:
Generating mutation plots.
Highly correlated genes for SART1:
Showing top 20/422 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SART1 | EIF1AD | 0.705954 | 4 | 0 | 4 |
| SART1 | BLACAT1 | 0.704327 | 3 | 0 | 3 |
| SART1 | PPP1R35 | 0.685216 | 4 | 0 | 3 |
| SART1 | TOP1MT | 0.674624 | 5 | 0 | 4 |
| SART1 | MZT1 | 0.672422 | 3 | 0 | 3 |
| SART1 | NSUN6 | 0.661631 | 3 | 0 | 3 |
| SART1 | YWHAG | 0.659656 | 4 | 0 | 4 |
| SART1 | PRPF19 | 0.654229 | 6 | 0 | 4 |
| SART1 | LONP1 | 0.652082 | 8 | 0 | 7 |
| SART1 | XPR1 | 0.650045 | 4 | 0 | 3 |
| SART1 | ADAM17 | 0.64141 | 4 | 0 | 3 |
| SART1 | PTPRZ1 | 0.640907 | 4 | 0 | 3 |
| SART1 | COA6 | 0.639725 | 4 | 0 | 3 |
| SART1 | U2SURP | 0.639157 | 7 | 0 | 6 |
| SART1 | HR | 0.638172 | 3 | 0 | 3 |
| SART1 | IAH1 | 0.635886 | 4 | 0 | 3 |
| SART1 | COCH | 0.632235 | 5 | 0 | 3 |
| SART1 | DUSP9 | 0.632212 | 3 | 0 | 3 |
| SART1 | EPPK1 | 0.63178 | 4 | 0 | 3 |
| SART1 | FMNL2 | 0.630124 | 5 | 0 | 4 |
For details and further investigation, click here
