| Full name: pre-mRNA processing factor 8 | Alias Symbol: PRPC8|Prp8|hPrp8|SNRNP220 | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 10594 | HGNC ID: HGNC:17340 | Ensembl Gene: ENSG00000174231 | OMIM ID: 607300 |
| Drug and gene relationship at DGIdb | |||
Expression of PRPF8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRPF8 | 10594 | 200000_s_at | 0.3330 | 0.1717 | |
| GSE20347 | PRPF8 | 10594 | 200000_s_at | 0.0985 | 0.5326 | |
| GSE23400 | PRPF8 | 10594 | 200000_s_at | 0.3221 | 0.0000 | |
| GSE26886 | PRPF8 | 10594 | 200000_s_at | 1.1232 | 0.0000 | |
| GSE29001 | PRPF8 | 10594 | 200000_s_at | -0.0883 | 0.8313 | |
| GSE38129 | PRPF8 | 10594 | 200000_s_at | 0.1290 | 0.2175 | |
| GSE45670 | PRPF8 | 10594 | 200000_s_at | 0.1832 | 0.2156 | |
| GSE53622 | PRPF8 | 10594 | 157008 | 0.2361 | 0.0000 | |
| GSE53624 | PRPF8 | 10594 | 157008 | 0.3617 | 0.0000 | |
| GSE63941 | PRPF8 | 10594 | 200000_s_at | 0.4879 | 0.0820 | |
| GSE77861 | PRPF8 | 10594 | 200000_s_at | 0.2319 | 0.3982 | |
| GSE97050 | PRPF8 | 10594 | A_23_P38219 | 0.4253 | 0.1694 | |
| SRP007169 | PRPF8 | 10594 | RNAseq | 1.2696 | 0.0010 | |
| SRP008496 | PRPF8 | 10594 | RNAseq | 0.9238 | 0.0005 | |
| SRP064894 | PRPF8 | 10594 | RNAseq | 0.1746 | 0.2015 | |
| SRP133303 | PRPF8 | 10594 | RNAseq | -0.0983 | 0.4006 | |
| SRP159526 | PRPF8 | 10594 | RNAseq | 0.2319 | 0.0417 | |
| SRP193095 | PRPF8 | 10594 | RNAseq | 0.3135 | 0.0041 | |
| SRP219564 | PRPF8 | 10594 | RNAseq | 0.3768 | 0.1991 | |
| TCGA | PRPF8 | 10594 | RNAseq | -0.0039 | 0.9244 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PRPF8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRPF8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRPF8 | 10594 | 5 | 2 | 23 | |
| GSE20123 | PRPF8 | 10594 | 5 | 3 | 22 | |
| GSE43470 | PRPF8 | 10594 | 3 | 6 | 34 | |
| GSE46452 | PRPF8 | 10594 | 34 | 1 | 24 | |
| GSE47630 | PRPF8 | 10594 | 8 | 1 | 31 | |
| GSE54993 | PRPF8 | 10594 | 9 | 3 | 58 | |
| GSE54994 | PRPF8 | 10594 | 8 | 8 | 37 | |
| GSE60625 | PRPF8 | 10594 | 4 | 0 | 7 | |
| GSE74703 | PRPF8 | 10594 | 2 | 3 | 31 | |
| GSE74704 | PRPF8 | 10594 | 3 | 1 | 16 | |
| TCGA | PRPF8 | 10594 | 20 | 21 | 55 |
Total number of gains: 101; Total number of losses: 49; Total Number of normals: 338.
Somatic mutations of PRPF8:
Generating mutation plots.
Highly correlated genes for PRPF8:
Showing top 20/543 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRPF8 | ABCC10 | 0.731572 | 4 | 0 | 3 |
| PRPF8 | DYRK2 | 0.719283 | 3 | 0 | 3 |
| PRPF8 | TXNDC12 | 0.704628 | 5 | 0 | 4 |
| PRPF8 | MMP15 | 0.679539 | 3 | 0 | 3 |
| PRPF8 | PITPNA-AS1 | 0.676165 | 5 | 0 | 4 |
| PRPF8 | NAA38 | 0.675056 | 5 | 0 | 3 |
| PRPF8 | RIOK1 | 0.6718 | 4 | 0 | 4 |
| PRPF8 | PLEKHG4B | 0.655626 | 4 | 0 | 3 |
| PRPF8 | SENP3 | 0.653777 | 9 | 0 | 9 |
| PRPF8 | SLC25A11 | 0.651334 | 10 | 0 | 10 |
| PRPF8 | PPIL1 | 0.650322 | 4 | 0 | 4 |
| PRPF8 | TBC1D7 | 0.645045 | 3 | 0 | 3 |
| PRPF8 | ADPGK | 0.636011 | 4 | 0 | 4 |
| PRPF8 | CTSD | 0.635437 | 4 | 0 | 3 |
| PRPF8 | PDCD2 | 0.631045 | 4 | 0 | 4 |
| PRPF8 | CENPL | 0.630578 | 4 | 0 | 4 |
| PRPF8 | HAUS6 | 0.629673 | 4 | 0 | 4 |
| PRPF8 | AURKAIP1 | 0.629032 | 4 | 0 | 3 |
| PRPF8 | LTBP3 | 0.62817 | 4 | 0 | 3 |
| PRPF8 | CSNK2A2 | 0.628073 | 4 | 0 | 3 |
For details and further investigation, click here
