| Full name: paired related homeobox 1 | Alias Symbol: PHOX1 | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 5396 | HGNC ID: HGNC:9142 | Ensembl Gene: ENSG00000116132 | OMIM ID: 167420 |
| Drug and gene relationship at DGIdb | |||
Expression of PRRX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRRX1 | 5396 | 226695_at | 0.2158 | 0.8392 | |
| GSE20347 | PRRX1 | 5396 | 205991_s_at | 0.2388 | 0.0111 | |
| GSE23400 | PRRX1 | 5396 | 205991_s_at | 0.3993 | 0.0011 | |
| GSE26886 | PRRX1 | 5396 | 226695_at | 2.0046 | 0.0048 | |
| GSE29001 | PRRX1 | 5396 | 205991_s_at | 0.1107 | 0.5364 | |
| GSE38129 | PRRX1 | 5396 | 205991_s_at | 0.3086 | 0.0075 | |
| GSE45670 | PRRX1 | 5396 | 226695_at | -0.9782 | 0.0659 | |
| GSE53622 | PRRX1 | 5396 | 6573 | 1.0205 | 0.0000 | |
| GSE53624 | PRRX1 | 5396 | 6573 | 1.3534 | 0.0000 | |
| GSE63941 | PRRX1 | 5396 | 226695_at | -5.6731 | 0.0000 | |
| GSE77861 | PRRX1 | 5396 | 226695_at | 0.9047 | 0.0524 | |
| GSE97050 | PRRX1 | 5396 | A_33_P3263890 | 0.4427 | 0.1553 | |
| SRP007169 | PRRX1 | 5396 | RNAseq | 3.7407 | 0.0000 | |
| SRP008496 | PRRX1 | 5396 | RNAseq | 4.5479 | 0.0000 | |
| SRP064894 | PRRX1 | 5396 | RNAseq | 1.2764 | 0.0001 | |
| SRP133303 | PRRX1 | 5396 | RNAseq | 1.5678 | 0.0000 | |
| SRP159526 | PRRX1 | 5396 | RNAseq | 0.6764 | 0.0594 | |
| SRP193095 | PRRX1 | 5396 | RNAseq | 2.4330 | 0.0000 | |
| SRP219564 | PRRX1 | 5396 | RNAseq | 0.9829 | 0.0877 | |
| TCGA | PRRX1 | 5396 | RNAseq | 0.5814 | 0.0001 |
Upregulated datasets: 8; Downregulated datasets: 1.
Survival by PRRX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRRX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRRX1 | 5396 | 12 | 1 | 17 | |
| GSE20123 | PRRX1 | 5396 | 12 | 1 | 17 | |
| GSE43470 | PRRX1 | 5396 | 7 | 2 | 34 | |
| GSE46452 | PRRX1 | 5396 | 3 | 1 | 55 | |
| GSE47630 | PRRX1 | 5396 | 14 | 0 | 26 | |
| GSE54993 | PRRX1 | 5396 | 0 | 6 | 64 | |
| GSE54994 | PRRX1 | 5396 | 16 | 0 | 37 | |
| GSE60625 | PRRX1 | 5396 | 0 | 0 | 11 | |
| GSE74703 | PRRX1 | 5396 | 7 | 2 | 27 | |
| GSE74704 | PRRX1 | 5396 | 6 | 0 | 14 | |
| TCGA | PRRX1 | 5396 | 42 | 3 | 51 |
Total number of gains: 119; Total number of losses: 16; Total Number of normals: 353.
Somatic mutations of PRRX1:
Generating mutation plots.
Highly correlated genes for PRRX1:
Showing top 20/1088 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRRX1 | C11orf96 | 0.787477 | 4 | 0 | 4 |
| PRRX1 | CTSK | 0.781665 | 12 | 0 | 11 |
| PRRX1 | NBPF20 | 0.777566 | 3 | 0 | 3 |
| PRRX1 | RBPJ | 0.776614 | 3 | 0 | 3 |
| PRRX1 | FCGR3A | 0.769247 | 3 | 0 | 3 |
| PRRX1 | LRRC8C | 0.765196 | 3 | 0 | 3 |
| PRRX1 | PCOLCE | 0.759871 | 12 | 0 | 11 |
| PRRX1 | COL8A1 | 0.758811 | 11 | 0 | 10 |
| PRRX1 | COL6A3 | 0.752913 | 12 | 0 | 11 |
| PRRX1 | COL12A1 | 0.75116 | 9 | 0 | 9 |
| PRRX1 | ZNF595 | 0.746327 | 3 | 0 | 3 |
| PRRX1 | ACTA2 | 0.741702 | 5 | 0 | 5 |
| PRRX1 | KCNJ2 | 0.740336 | 3 | 0 | 3 |
| PRRX1 | VCAM1 | 0.740159 | 10 | 0 | 9 |
| PRRX1 | PKIG | 0.733932 | 5 | 0 | 5 |
| PRRX1 | TMEM200A | 0.733692 | 8 | 0 | 8 |
| PRRX1 | ZNF469 | 0.733333 | 7 | 0 | 7 |
| PRRX1 | FNDC1 | 0.732799 | 9 | 0 | 8 |
| PRRX1 | SLC39A13 | 0.731206 | 6 | 0 | 6 |
| PRRX1 | DNM3OS | 0.731098 | 4 | 0 | 3 |
For details and further investigation, click here
