| Full name: aldo-keto reductase family 1 member C1 | Alias Symbol: DDH|MBAB|DD1|HAKRC | ||
| Type: protein-coding gene | Cytoband: 10p15.1 | ||
| Entrez ID: 1645 | HGNC ID: HGNC:384 | Ensembl Gene: ENSG00000187134 | OMIM ID: 600449 |
| Drug and gene relationship at DGIdb | |||
Expression of AKR1C1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR1C1 | 1645 | 216594_x_at | 0.2083 | 0.9222 | |
| GSE20347 | AKR1C1 | 1645 | 204151_x_at | 1.1541 | 0.0367 | |
| GSE23400 | AKR1C1 | 1645 | 204151_x_at | 0.5065 | 0.0911 | |
| GSE26886 | AKR1C1 | 1645 | 204151_x_at | -0.0339 | 0.9669 | |
| GSE29001 | AKR1C1 | 1645 | 204151_x_at | 0.1744 | 0.8292 | |
| GSE38129 | AKR1C1 | 1645 | 204151_x_at | 0.9593 | 0.0401 | |
| GSE45670 | AKR1C1 | 1645 | 204151_x_at | 0.9091 | 0.1245 | |
| GSE53622 | AKR1C1 | 1645 | 148483 | 0.9240 | 0.0056 | |
| GSE53624 | AKR1C1 | 1645 | 148483 | 1.1104 | 0.0000 | |
| GSE63941 | AKR1C1 | 1645 | 204151_x_at | -1.6645 | 0.4825 | |
| GSE77861 | AKR1C1 | 1645 | 204151_x_at | 1.0313 | 0.2969 | |
| GSE97050 | AKR1C1 | 1645 | A_23_P257971 | 0.2594 | 0.6428 | |
| SRP007169 | AKR1C1 | 1645 | RNAseq | 4.1442 | 0.0000 | |
| SRP008496 | AKR1C1 | 1645 | RNAseq | 3.9126 | 0.0000 | |
| SRP064894 | AKR1C1 | 1645 | RNAseq | 0.4257 | 0.3477 | |
| SRP133303 | AKR1C1 | 1645 | RNAseq | -0.4032 | 0.3135 | |
| SRP159526 | AKR1C1 | 1645 | RNAseq | 3.9178 | 0.0000 | |
| SRP193095 | AKR1C1 | 1645 | RNAseq | 1.9818 | 0.0000 | |
| TCGA | AKR1C1 | 1645 | RNAseq | 0.1596 | 0.5431 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by AKR1C1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKR1C1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR1C1 | 1645 | 6 | 7 | 17 | |
| GSE20123 | AKR1C1 | 1645 | 6 | 6 | 18 | |
| GSE43470 | AKR1C1 | 1645 | 4 | 6 | 33 | |
| GSE46452 | AKR1C1 | 1645 | 2 | 14 | 43 | |
| GSE47630 | AKR1C1 | 1645 | 6 | 14 | 20 | |
| GSE54993 | AKR1C1 | 1645 | 11 | 0 | 59 | |
| GSE54994 | AKR1C1 | 1645 | 4 | 10 | 39 | |
| GSE60625 | AKR1C1 | 1645 | 0 | 0 | 11 | |
| GSE74703 | AKR1C1 | 1645 | 2 | 4 | 30 | |
| GSE74704 | AKR1C1 | 1645 | 1 | 5 | 14 | |
| TCGA | AKR1C1 | 1645 | 19 | 27 | 50 |
Total number of gains: 61; Total number of losses: 93; Total Number of normals: 334.
Somatic mutations of AKR1C1:
Generating mutation plots.
Highly correlated genes for AKR1C1:
Showing top 20/139 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR1C1 | AKR1C2 | 0.993399 | 9 | 0 | 9 |
| AKR1C1 | AKR1C3 | 0.888724 | 12 | 0 | 12 |
| AKR1C1 | AKR1C4 | 0.754223 | 11 | 0 | 11 |
| AKR1C1 | CD44 | 0.720787 | 4 | 0 | 4 |
| AKR1C1 | GPX2 | 0.705464 | 11 | 0 | 10 |
| AKR1C1 | SLC28A3 | 0.703073 | 3 | 0 | 3 |
| AKR1C1 | AKR1B10 | 0.700913 | 10 | 0 | 10 |
| AKR1C1 | PRSS12 | 0.682073 | 3 | 0 | 3 |
| AKR1C1 | SLC7A11 | 0.680633 | 12 | 0 | 11 |
| AKR1C1 | SRXN1 | 0.677363 | 6 | 0 | 5 |
| AKR1C1 | NQO1 | 0.667707 | 10 | 0 | 9 |
| AKR1C1 | IL1R2 | 0.643214 | 3 | 0 | 3 |
| AKR1C1 | NIPAL4 | 0.642427 | 3 | 0 | 3 |
| AKR1C1 | CYP4F11 | 0.639495 | 11 | 0 | 9 |
| AKR1C1 | GSTM3 | 0.634261 | 10 | 0 | 10 |
| AKR1C1 | PIR | 0.633882 | 10 | 0 | 9 |
| AKR1C1 | GCLC | 0.633837 | 11 | 0 | 10 |
| AKR1C1 | AEBP2 | 0.632617 | 3 | 0 | 3 |
| AKR1C1 | ARV1 | 0.632489 | 3 | 0 | 3 |
| AKR1C1 | PTPMT1 | 0.628872 | 3 | 0 | 3 |
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