| Full name: phosphoserine aminotransferase 1 | Alias Symbol: PSA | ||
| Type: protein-coding gene | Cytoband: 9q21.2 | ||
| Entrez ID: 29968 | HGNC ID: HGNC:19129 | Ensembl Gene: ENSG00000135069 | OMIM ID: 610936 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PSAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSAT1 | 29968 | 223062_s_at | 0.7563 | 0.2944 | |
| GSE20347 | PSAT1 | 29968 | 220892_s_at | 0.4305 | 0.0049 | |
| GSE23400 | PSAT1 | 29968 | 220892_s_at | 0.5558 | 0.0000 | |
| GSE26886 | PSAT1 | 29968 | 223062_s_at | -0.4402 | 0.0876 | |
| GSE29001 | PSAT1 | 29968 | 220892_s_at | 0.1585 | 0.1335 | |
| GSE38129 | PSAT1 | 29968 | 220892_s_at | 0.5820 | 0.0002 | |
| GSE45670 | PSAT1 | 29968 | 223062_s_at | 0.4412 | 0.2120 | |
| GSE53622 | PSAT1 | 29968 | 7296 | 0.5500 | 0.0002 | |
| GSE53624 | PSAT1 | 29968 | 7296 | 0.8518 | 0.0000 | |
| GSE63941 | PSAT1 | 29968 | 223062_s_at | 0.9034 | 0.2879 | |
| GSE77861 | PSAT1 | 29968 | 223062_s_at | 0.5577 | 0.0840 | |
| GSE97050 | PSAT1 | 29968 | A_23_P259692 | 0.3175 | 0.3619 | |
| SRP007169 | PSAT1 | 29968 | RNAseq | 1.8717 | 0.0007 | |
| SRP008496 | PSAT1 | 29968 | RNAseq | 1.4157 | 0.0003 | |
| SRP064894 | PSAT1 | 29968 | RNAseq | 0.6718 | 0.0661 | |
| SRP133303 | PSAT1 | 29968 | RNAseq | 0.7387 | 0.1006 | |
| SRP159526 | PSAT1 | 29968 | RNAseq | 0.6630 | 0.0113 | |
| SRP193095 | PSAT1 | 29968 | RNAseq | 0.4702 | 0.0558 | |
| SRP219564 | PSAT1 | 29968 | RNAseq | 1.1039 | 0.0190 | |
| TCGA | PSAT1 | 29968 | RNAseq | 0.3018 | 0.0020 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PSAT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSAT1 | 29968 | 5 | 10 | 15 | |
| GSE20123 | PSAT1 | 29968 | 5 | 10 | 15 | |
| GSE43470 | PSAT1 | 29968 | 6 | 5 | 32 | |
| GSE46452 | PSAT1 | 29968 | 6 | 14 | 39 | |
| GSE47630 | PSAT1 | 29968 | 1 | 18 | 21 | |
| GSE54993 | PSAT1 | 29968 | 4 | 2 | 64 | |
| GSE54994 | PSAT1 | 29968 | 4 | 12 | 37 | |
| GSE60625 | PSAT1 | 29968 | 0 | 0 | 11 | |
| GSE74703 | PSAT1 | 29968 | 5 | 4 | 27 | |
| GSE74704 | PSAT1 | 29968 | 3 | 7 | 10 | |
| TCGA | PSAT1 | 29968 | 19 | 28 | 49 |
Total number of gains: 58; Total number of losses: 110; Total Number of normals: 320.
Somatic mutations of PSAT1:
Generating mutation plots.
Highly correlated genes for PSAT1:
Showing top 20/386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSAT1 | PNPO | 0.709128 | 3 | 0 | 3 |
| PSAT1 | BAIAP2L2 | 0.692026 | 3 | 0 | 3 |
| PSAT1 | SCD | 0.659069 | 4 | 0 | 3 |
| PSAT1 | SLC2A9 | 0.651281 | 3 | 0 | 3 |
| PSAT1 | G3BP1 | 0.651056 | 5 | 0 | 5 |
| PSAT1 | SERPINI1 | 0.641007 | 4 | 0 | 3 |
| PSAT1 | CABLES2 | 0.636924 | 3 | 0 | 3 |
| PSAT1 | PDP2 | 0.633748 | 4 | 0 | 3 |
| PSAT1 | LPAR3 | 0.630552 | 4 | 0 | 3 |
| PSAT1 | MZT1 | 0.62517 | 5 | 0 | 4 |
| PSAT1 | DKC1 | 0.623325 | 3 | 0 | 3 |
| PSAT1 | XPOT | 0.622942 | 11 | 0 | 9 |
| PSAT1 | PDK1 | 0.622117 | 4 | 0 | 3 |
| PSAT1 | CNNM4 | 0.621022 | 5 | 0 | 3 |
| PSAT1 | NCBP1 | 0.619389 | 6 | 0 | 5 |
| PSAT1 | BCAM | 0.617281 | 3 | 0 | 3 |
| PSAT1 | TLCD1 | 0.61468 | 6 | 0 | 5 |
| PSAT1 | ASNS | 0.612401 | 8 | 0 | 6 |
| PSAT1 | TBX1 | 0.611863 | 3 | 0 | 3 |
| PSAT1 | PRC1 | 0.609307 | 10 | 0 | 9 |
For details and further investigation, click here
