| Full name: proteasome activator subunit 3 | Alias Symbol: Ki|PA28-gamma|REG-GAMMA|PA28G | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 10197 | HGNC ID: HGNC:9570 | Ensembl Gene: ENSG00000131467 | OMIM ID: 605129 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PSME3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation |
Expression of PSME3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSME3 | 10197 | 209852_x_at | 0.5614 | 0.1511 | |
| GSE20347 | PSME3 | 10197 | 209852_x_at | 0.2502 | 0.1226 | |
| GSE23400 | PSME3 | 10197 | 209852_x_at | 0.4184 | 0.0000 | |
| GSE26886 | PSME3 | 10197 | 209852_x_at | -0.3813 | 0.3653 | |
| GSE29001 | PSME3 | 10197 | 209852_x_at | 0.0978 | 0.8073 | |
| GSE38129 | PSME3 | 10197 | 209852_x_at | 0.5101 | 0.0003 | |
| GSE45670 | PSME3 | 10197 | 200987_x_at | 0.6166 | 0.0005 | |
| GSE53622 | PSME3 | 10197 | 15775 | 0.3785 | 0.0000 | |
| GSE53624 | PSME3 | 10197 | 15775 | 0.4907 | 0.0000 | |
| GSE63941 | PSME3 | 10197 | 200987_x_at | 0.7204 | 0.0871 | |
| GSE77861 | PSME3 | 10197 | 209852_x_at | 0.6093 | 0.0048 | |
| GSE97050 | PSME3 | 10197 | A_23_P164141 | 0.5846 | 0.1725 | |
| SRP007169 | PSME3 | 10197 | RNAseq | 0.3323 | 0.3323 | |
| SRP008496 | PSME3 | 10197 | RNAseq | 0.1546 | 0.4277 | |
| SRP064894 | PSME3 | 10197 | RNAseq | 0.1693 | 0.2727 | |
| SRP133303 | PSME3 | 10197 | RNAseq | 0.5171 | 0.0001 | |
| SRP159526 | PSME3 | 10197 | RNAseq | 0.2317 | 0.4291 | |
| SRP193095 | PSME3 | 10197 | RNAseq | 0.2337 | 0.0271 | |
| SRP219564 | PSME3 | 10197 | RNAseq | 0.1117 | 0.7332 | |
| TCGA | PSME3 | 10197 | RNAseq | 0.1127 | 0.0075 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSME3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSME3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSME3 | 10197 | 6 | 2 | 22 | |
| GSE20123 | PSME3 | 10197 | 6 | 2 | 22 | |
| GSE43470 | PSME3 | 10197 | 1 | 2 | 40 | |
| GSE46452 | PSME3 | 10197 | 34 | 0 | 25 | |
| GSE47630 | PSME3 | 10197 | 8 | 1 | 31 | |
| GSE54993 | PSME3 | 10197 | 3 | 4 | 63 | |
| GSE54994 | PSME3 | 10197 | 8 | 5 | 40 | |
| GSE60625 | PSME3 | 10197 | 4 | 0 | 7 | |
| GSE74703 | PSME3 | 10197 | 1 | 1 | 34 | |
| GSE74704 | PSME3 | 10197 | 4 | 1 | 15 | |
| TCGA | PSME3 | 10197 | 22 | 7 | 67 |
Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.
Somatic mutations of PSME3:
Generating mutation plots.
Highly correlated genes for PSME3:
Showing top 20/1324 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSME3 | OLFM2 | 0.74806 | 3 | 0 | 3 |
| PSME3 | WIPI1 | 0.746148 | 3 | 0 | 3 |
| PSME3 | GMCL1 | 0.730863 | 3 | 0 | 3 |
| PSME3 | TUBG1 | 0.728146 | 10 | 0 | 9 |
| PSME3 | PHTF1 | 0.727043 | 3 | 0 | 3 |
| PSME3 | KCTD13 | 0.72568 | 3 | 0 | 3 |
| PSME3 | TADA3 | 0.721637 | 4 | 0 | 4 |
| PSME3 | CMIP | 0.719351 | 5 | 0 | 5 |
| PSME3 | SPNS1 | 0.718115 | 5 | 0 | 5 |
| PSME3 | EFTUD2 | 0.716326 | 8 | 0 | 7 |
| PSME3 | LRRC59 | 0.713106 | 9 | 0 | 8 |
| PSME3 | RAB11B | 0.710087 | 3 | 0 | 3 |
| PSME3 | IRF2BPL | 0.707542 | 3 | 0 | 3 |
| PSME3 | KTI12 | 0.707007 | 4 | 0 | 3 |
| PSME3 | CLEC11A | 0.698514 | 3 | 0 | 3 |
| PSME3 | SFT2D3 | 0.698127 | 3 | 0 | 3 |
| PSME3 | LDLRAP1 | 0.697808 | 4 | 0 | 3 |
| PSME3 | PPP1R9B | 0.697642 | 4 | 0 | 4 |
| PSME3 | TPM3 | 0.694211 | 7 | 0 | 6 |
| PSME3 | MTCH2 | 0.692569 | 5 | 0 | 5 |
For details and further investigation, click here
