| Full name: prostaglandin E receptor 4 | Alias Symbol: EP4 | ||
| Type: protein-coding gene | Cytoband: 5p13.1 | ||
| Entrez ID: 5734 | HGNC ID: HGNC:9596 | Ensembl Gene: ENSG00000171522 | OMIM ID: 601586 |
| Drug and gene relationship at DGIdb | |||
PTGER4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels | |
| hsa04924 | Renin secretion |
Expression of PTGER4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTGER4 | 5734 | 204897_at | -0.0994 | 0.9422 | |
| GSE20347 | PTGER4 | 5734 | 204897_at | 0.4841 | 0.2675 | |
| GSE23400 | PTGER4 | 5734 | 204896_s_at | -0.1580 | 0.0033 | |
| GSE26886 | PTGER4 | 5734 | 204897_at | 0.2361 | 0.6996 | |
| GSE29001 | PTGER4 | 5734 | 204897_at | -0.4777 | 0.3937 | |
| GSE38129 | PTGER4 | 5734 | 204897_at | 0.1961 | 0.5674 | |
| GSE45670 | PTGER4 | 5734 | 204897_at | -0.7157 | 0.0286 | |
| GSE53622 | PTGER4 | 5734 | 41692 | -0.1484 | 0.2011 | |
| GSE53624 | PTGER4 | 5734 | 36191 | 0.0160 | 0.9268 | |
| GSE63941 | PTGER4 | 5734 | 204897_at | -2.4961 | 0.0835 | |
| GSE77861 | PTGER4 | 5734 | 204897_at | 1.0007 | 0.2068 | |
| GSE97050 | PTGER4 | 5734 | A_23_P148047 | 0.2684 | 0.2156 | |
| SRP007169 | PTGER4 | 5734 | RNAseq | 0.6846 | 0.1851 | |
| SRP064894 | PTGER4 | 5734 | RNAseq | 0.0024 | 0.9938 | |
| SRP133303 | PTGER4 | 5734 | RNAseq | 0.0174 | 0.9320 | |
| SRP159526 | PTGER4 | 5734 | RNAseq | 0.8899 | 0.0190 | |
| SRP193095 | PTGER4 | 5734 | RNAseq | -0.3453 | 0.2463 | |
| SRP219564 | PTGER4 | 5734 | RNAseq | 0.8050 | 0.2808 | |
| TCGA | PTGER4 | 5734 | RNAseq | -0.4583 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PTGER4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTGER4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTGER4 | 5734 | 9 | 0 | 21 | |
| GSE20123 | PTGER4 | 5734 | 9 | 0 | 21 | |
| GSE43470 | PTGER4 | 5734 | 17 | 0 | 26 | |
| GSE46452 | PTGER4 | 5734 | 5 | 22 | 32 | |
| GSE47630 | PTGER4 | 5734 | 6 | 12 | 22 | |
| GSE54993 | PTGER4 | 5734 | 5 | 4 | 61 | |
| GSE54994 | PTGER4 | 5734 | 24 | 2 | 27 | |
| GSE60625 | PTGER4 | 5734 | 0 | 0 | 11 | |
| GSE74703 | PTGER4 | 5734 | 13 | 0 | 23 | |
| GSE74704 | PTGER4 | 5734 | 8 | 0 | 12 | |
| TCGA | PTGER4 | 5734 | 53 | 6 | 37 |
Total number of gains: 149; Total number of losses: 46; Total Number of normals: 293.
Somatic mutations of PTGER4:
Generating mutation plots.
Highly correlated genes for PTGER4:
Showing top 20/368 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTGER4 | DOCK7 | 0.743598 | 4 | 0 | 4 |
| PTGER4 | MAGED2 | 0.73585 | 3 | 0 | 3 |
| PTGER4 | RAMP2 | 0.723539 | 3 | 0 | 3 |
| PTGER4 | WDR35 | 0.716074 | 4 | 0 | 3 |
| PTGER4 | INTS10 | 0.71422 | 3 | 0 | 3 |
| PTGER4 | CPVL | 0.705583 | 3 | 0 | 3 |
| PTGER4 | ACSS3 | 0.704563 | 3 | 0 | 3 |
| PTGER4 | HDAC9 | 0.701342 | 4 | 0 | 4 |
| PTGER4 | KCNE3 | 0.698541 | 3 | 0 | 3 |
| PTGER4 | TLR4 | 0.691148 | 3 | 0 | 3 |
| PTGER4 | BBS12 | 0.685893 | 3 | 0 | 3 |
| PTGER4 | TTC19 | 0.682941 | 3 | 0 | 3 |
| PTGER4 | TMEM168 | 0.680561 | 3 | 0 | 3 |
| PTGER4 | ETV5 | 0.68052 | 3 | 0 | 3 |
| PTGER4 | SPRED1 | 0.671297 | 4 | 0 | 3 |
| PTGER4 | STAT5A | 0.670279 | 4 | 0 | 4 |
| PTGER4 | FUNDC2 | 0.667492 | 4 | 0 | 4 |
| PTGER4 | PLOD3 | 0.664922 | 3 | 0 | 3 |
| PTGER4 | ACVRL1 | 0.663191 | 3 | 0 | 3 |
| PTGER4 | CDCA2 | 0.660754 | 3 | 0 | 3 |
For details and further investigation, click here
