TLR4

 

Full name: toll like receptor 4 Alias Symbol: hToll|CD284|TLR-4|ARMD10
Type: protein-coding gene Cytoband: 9q33.1
Entrez ID: 7099 HGNC ID: HGNC:11850 Ensembl Gene: ENSG00000136869 OMIM ID: 603030
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TLR4 involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04066HIF-1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05205Proteoglycans in cancer
hsa05321Inflammatory bowel disease (IBD)

 

Expression of TLR4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TLR4 7099 221060_s_at -0.0703 0.9581
GSE20347 TLR4 7099 221060_s_at 0.0629 0.1599
GSE23400 TLR4 7099 221060_s_at 0.0876 0.0668
GSE26886 TLR4 7099 1552798_a_at 0.1658 0.4157
GSE29001 TLR4 7099 221060_s_at -0.0664 0.6661
GSE38129 TLR4 7099 221060_s_at -0.0051 0.9294
GSE45670 TLR4 7099 1552798_a_at -0.1624 0.3401
GSE53622 TLR4 7099 38813 0.0745 0.6426
GSE53624 TLR4 7099 38813 0.3998 0.0054
GSE63941 TLR4 7099 1552798_a_at -0.4070 0.3880
GSE77861 TLR4 7099 1552798_a_at -0.0481 0.7080
GSE97050 TLR4 7099 A_24_P69538 0.3584 0.2285
SRP007169 TLR4 7099 RNAseq 2.9087 0.0000
SRP008496 TLR4 7099 RNAseq 2.2387 0.0000
SRP064894 TLR4 7099 RNAseq 0.6929 0.0626
SRP133303 TLR4 7099 RNAseq 0.3475 0.1381
SRP159526 TLR4 7099 RNAseq 0.8305 0.2327
SRP193095 TLR4 7099 RNAseq 0.8150 0.0018
SRP219564 TLR4 7099 RNAseq 0.7761 0.2142
TCGA TLR4 7099 RNAseq -0.3941 0.0127

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by TLR4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TLR4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TLR4 7099 4 9 17
GSE20123 TLR4 7099 4 9 17
GSE43470 TLR4 7099 4 5 34
GSE46452 TLR4 7099 6 13 40
GSE47630 TLR4 7099 3 16 21
GSE54993 TLR4 7099 3 3 64
GSE54994 TLR4 7099 9 10 34
GSE60625 TLR4 7099 0 0 11
GSE74703 TLR4 7099 4 4 28
GSE74704 TLR4 7099 2 6 12
TCGA TLR4 7099 27 23 46

Total number of gains: 66; Total number of losses: 98; Total Number of normals: 324.  

 

Somatic mutations of TLR4:

 

Generating mutation plots.

 

Highly correlated genes for TLR4:

 

Showing top 20/422 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TLR4NRROS0.755584404
TLR4NNMT0.724359303
TLR4C19orf380.703099303
TLR4SPI10.696276303
TLR4PTGER40.691148303
TLR4CSF2RA0.683746303
TLR4MS4A70.679537303
TLR4ITGAM0.676511505
TLR4EGFLAM0.672969303
TLR4CYBB0.67111605
TLR4GGT50.67107505
TLR4GPC60.67012604
TLR4CCR10.66745504
TLR4MTNR1B0.658625303
TLR4GATA60.65697404
TLR4STAB10.656962605
TLR4ICAM20.655717403
TLR4SH2B30.654306707
TLR4TIE10.653102605
TLR4MS4A4A0.651541807

For details and further investigation, click here