| Full name: protein tyrosine phosphatase receptor type O | Alias Symbol: PTPU2|GLEPP1|PTP-U2|PTP-oc|NPHS6 | ||
| Type: protein-coding gene | Cytoband: 12p12.3 | ||
| Entrez ID: 5800 | HGNC ID: HGNC:9678 | Ensembl Gene: ENSG00000151490 | OMIM ID: 600579 |
| Drug and gene relationship at DGIdb | |||
Expression of PTPRO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPRO | 5800 | 211600_at | -0.2482 | 0.6493 | |
| GSE20347 | PTPRO | 5800 | 211600_at | -0.0749 | 0.6718 | |
| GSE23400 | PTPRO | 5800 | 211600_at | -0.2243 | 0.0190 | |
| GSE26886 | PTPRO | 5800 | 211600_at | -0.1254 | 0.7073 | |
| GSE29001 | PTPRO | 5800 | 211600_at | -0.6320 | 0.0571 | |
| GSE38129 | PTPRO | 5800 | 211600_at | -0.6003 | 0.0140 | |
| GSE45670 | PTPRO | 5800 | 211600_at | -0.3903 | 0.0239 | |
| GSE53622 | PTPRO | 5800 | 78269 | 0.8242 | 0.0000 | |
| GSE53624 | PTPRO | 5800 | 78269 | 1.0516 | 0.0000 | |
| GSE63941 | PTPRO | 5800 | 211600_at | 2.4555 | 0.0001 | |
| GSE77861 | PTPRO | 5800 | 211600_at | 0.1667 | 0.6765 | |
| SRP007169 | PTPRO | 5800 | RNAseq | 2.0446 | 0.0273 | |
| SRP064894 | PTPRO | 5800 | RNAseq | 1.6705 | 0.0000 | |
| SRP133303 | PTPRO | 5800 | RNAseq | 1.2168 | 0.0000 | |
| SRP159526 | PTPRO | 5800 | RNAseq | 0.8586 | 0.3054 | |
| SRP193095 | PTPRO | 5800 | RNAseq | 1.0036 | 0.0000 | |
| SRP219564 | PTPRO | 5800 | RNAseq | 1.0993 | 0.0867 | |
| TCGA | PTPRO | 5800 | RNAseq | 0.2009 | 0.3908 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by PTPRO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPRO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPRO | 5800 | 6 | 2 | 22 | |
| GSE20123 | PTPRO | 5800 | 6 | 2 | 22 | |
| GSE43470 | PTPRO | 5800 | 9 | 4 | 30 | |
| GSE46452 | PTPRO | 5800 | 10 | 1 | 48 | |
| GSE47630 | PTPRO | 5800 | 14 | 1 | 25 | |
| GSE54993 | PTPRO | 5800 | 1 | 9 | 60 | |
| GSE54994 | PTPRO | 5800 | 11 | 2 | 40 | |
| GSE60625 | PTPRO | 5800 | 0 | 1 | 10 | |
| GSE74703 | PTPRO | 5800 | 9 | 3 | 24 | |
| GSE74704 | PTPRO | 5800 | 4 | 1 | 15 | |
| TCGA | PTPRO | 5800 | 41 | 5 | 50 |
Total number of gains: 111; Total number of losses: 31; Total Number of normals: 346.
Somatic mutations of PTPRO:
Generating mutation plots.
Highly correlated genes for PTPRO:
Showing top 20/217 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPRO | ADRB3 | 0.713067 | 3 | 0 | 3 |
| PTPRO | PRKACA | 0.687536 | 3 | 0 | 3 |
| PTPRO | MUC3B | 0.679001 | 5 | 0 | 5 |
| PTPRO | RAB3IL1 | 0.678773 | 5 | 0 | 4 |
| PTPRO | RAB3A | 0.674505 | 5 | 0 | 5 |
| PTPRO | GDF3 | 0.670939 | 3 | 0 | 3 |
| PTPRO | DICER1 | 0.665673 | 3 | 0 | 3 |
| PTPRO | ART1 | 0.664299 | 3 | 0 | 3 |
| PTPRO | C9orf16 | 0.661667 | 3 | 0 | 3 |
| PTPRO | FCN2 | 0.658261 | 4 | 0 | 4 |
| PTPRO | DGCR9 | 0.65584 | 3 | 0 | 3 |
| PTPRO | FAM223B | 0.655014 | 3 | 0 | 3 |
| PTPRO | CD22 | 0.654875 | 5 | 0 | 5 |
| PTPRO | NOX5 | 0.647677 | 5 | 0 | 3 |
| PTPRO | OPHN1 | 0.646491 | 5 | 0 | 3 |
| PTPRO | LILRB1 | 0.6452 | 4 | 0 | 3 |
| PTPRO | LENEP | 0.644045 | 3 | 0 | 3 |
| PTPRO | ENGASE | 0.634949 | 4 | 0 | 4 |
| PTPRO | DGCR5 | 0.634341 | 4 | 0 | 3 |
| PTPRO | LINC00652 | 0.630513 | 5 | 0 | 4 |
For details and further investigation, click here
