| Full name: RAB3A, member RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 5864 | HGNC ID: HGNC:9777 | Ensembl Gene: ENSG00000105649 | OMIM ID: 179490 |
| Drug and gene relationship at DGIdb | |||
RAB3A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04911 | Insulin secretion |
Expression of RAB3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB3A | 5864 | 204974_at | 0.0876 | 0.7917 | |
| GSE20347 | RAB3A | 5864 | 204974_at | 0.0491 | 0.4890 | |
| GSE23400 | RAB3A | 5864 | 204974_at | -0.0762 | 0.0682 | |
| GSE26886 | RAB3A | 5864 | 204974_at | 0.1830 | 0.1736 | |
| GSE29001 | RAB3A | 5864 | 204974_at | -0.1437 | 0.3664 | |
| GSE38129 | RAB3A | 5864 | 204974_at | -0.1169 | 0.1067 | |
| GSE45670 | RAB3A | 5864 | 204974_at | 0.0599 | 0.5885 | |
| GSE53622 | RAB3A | 5864 | 130174 | -0.1335 | 0.2943 | |
| GSE53624 | RAB3A | 5864 | 130174 | 0.2978 | 0.0004 | |
| GSE63941 | RAB3A | 5864 | 204974_at | -0.1248 | 0.4817 | |
| GSE77861 | RAB3A | 5864 | 204974_at | -0.0237 | 0.9068 | |
| GSE97050 | RAB3A | 5864 | A_33_P3314550 | -0.2146 | 0.5276 | |
| SRP133303 | RAB3A | 5864 | RNAseq | -0.1757 | 0.5911 | |
| SRP159526 | RAB3A | 5864 | RNAseq | 0.0896 | 0.8339 | |
| SRP219564 | RAB3A | 5864 | RNAseq | 0.5796 | 0.3217 | |
| TCGA | RAB3A | 5864 | RNAseq | -0.2701 | 0.0708 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RAB3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB3A | 5864 | 4 | 4 | 22 | |
| GSE20123 | RAB3A | 5864 | 3 | 2 | 25 | |
| GSE43470 | RAB3A | 5864 | 2 | 6 | 35 | |
| GSE46452 | RAB3A | 5864 | 47 | 1 | 11 | |
| GSE47630 | RAB3A | 5864 | 4 | 8 | 28 | |
| GSE54993 | RAB3A | 5864 | 15 | 4 | 51 | |
| GSE54994 | RAB3A | 5864 | 6 | 13 | 34 | |
| GSE60625 | RAB3A | 5864 | 9 | 0 | 2 | |
| GSE74703 | RAB3A | 5864 | 2 | 4 | 30 | |
| GSE74704 | RAB3A | 5864 | 0 | 2 | 18 | |
| TCGA | RAB3A | 5864 | 17 | 9 | 70 |
Total number of gains: 109; Total number of losses: 53; Total Number of normals: 326.
Somatic mutations of RAB3A:
Generating mutation plots.
Highly correlated genes for RAB3A:
Showing top 20/444 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB3A | ZFYVE9 | 0.780399 | 3 | 0 | 3 |
| RAB3A | TTYH2 | 0.734186 | 3 | 0 | 3 |
| RAB3A | PYROXD2 | 0.730482 | 3 | 0 | 3 |
| RAB3A | PI16 | 0.723857 | 4 | 0 | 4 |
| RAB3A | PI4KB | 0.71594 | 3 | 0 | 3 |
| RAB3A | ICAM5 | 0.713969 | 3 | 0 | 3 |
| RAB3A | STAC | 0.712409 | 3 | 0 | 3 |
| RAB3A | SLC39A13 | 0.703838 | 3 | 0 | 3 |
| RAB3A | MID1IP1 | 0.702021 | 4 | 0 | 4 |
| RAB3A | CD6 | 0.700345 | 3 | 0 | 3 |
| RAB3A | SLIT3 | 0.697682 | 3 | 0 | 3 |
| RAB3A | R3HDM2 | 0.696193 | 3 | 0 | 3 |
| RAB3A | FAM43B | 0.692908 | 3 | 0 | 3 |
| RAB3A | PREX2 | 0.685629 | 4 | 0 | 3 |
| RAB3A | BRD2 | 0.681562 | 3 | 0 | 3 |
| RAB3A | GFRA1 | 0.680038 | 4 | 0 | 3 |
| RAB3A | MINK1 | 0.675256 | 3 | 0 | 3 |
| RAB3A | PTPRO | 0.674505 | 5 | 0 | 5 |
| RAB3A | RILP | 0.673196 | 4 | 0 | 4 |
| RAB3A | RAPGEF1 | 0.66932 | 3 | 0 | 3 |
For details and further investigation, click here
