| Full name: vascular endothelial growth factor C | Alias Symbol: VRP|VEGF-C | ||
| Type: protein-coding gene | Cytoband: 4q34.3 | ||
| Entrez ID: 7424 | HGNC ID: HGNC:12682 | Ensembl Gene: ENSG00000150630 | OMIM ID: 601528 |
| Drug and gene relationship at DGIdb | |||
VEGFC involved pathways:
Expression of VEGFC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VEGFC | 7424 | 209946_at | 0.0248 | 0.9846 | |
| GSE20347 | VEGFC | 7424 | 209946_at | 0.1666 | 0.5739 | |
| GSE23400 | VEGFC | 7424 | 209946_at | 0.3667 | 0.0057 | |
| GSE26886 | VEGFC | 7424 | 209946_at | 1.4431 | 0.0128 | |
| GSE29001 | VEGFC | 7424 | 209946_at | 0.8949 | 0.1292 | |
| GSE38129 | VEGFC | 7424 | 209946_at | -0.1854 | 0.5654 | |
| GSE45670 | VEGFC | 7424 | 209946_at | -0.1711 | 0.8541 | |
| GSE53622 | VEGFC | 7424 | 42609 | 0.1511 | 0.4179 | |
| GSE53624 | VEGFC | 7424 | 42609 | 0.6383 | 0.0000 | |
| GSE63941 | VEGFC | 7424 | 209946_at | -4.5914 | 0.0022 | |
| GSE77861 | VEGFC | 7424 | 209946_at | -0.0380 | 0.8325 | |
| GSE97050 | VEGFC | 7424 | A_23_P167096 | 0.4728 | 0.4206 | |
| SRP007169 | VEGFC | 7424 | RNAseq | 0.7048 | 0.2321 | |
| SRP064894 | VEGFC | 7424 | RNAseq | 0.7078 | 0.0009 | |
| SRP133303 | VEGFC | 7424 | RNAseq | 0.6817 | 0.1198 | |
| SRP159526 | VEGFC | 7424 | RNAseq | 0.1746 | 0.6406 | |
| SRP219564 | VEGFC | 7424 | RNAseq | 0.9961 | 0.1381 | |
| TCGA | VEGFC | 7424 | RNAseq | 0.2595 | 0.1660 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by VEGFC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VEGFC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VEGFC | 7424 | 1 | 10 | 19 | |
| GSE20123 | VEGFC | 7424 | 1 | 10 | 19 | |
| GSE43470 | VEGFC | 7424 | 0 | 14 | 29 | |
| GSE46452 | VEGFC | 7424 | 1 | 36 | 22 | |
| GSE47630 | VEGFC | 7424 | 0 | 22 | 18 | |
| GSE54993 | VEGFC | 7424 | 10 | 0 | 60 | |
| GSE54994 | VEGFC | 7424 | 2 | 12 | 39 | |
| GSE60625 | VEGFC | 7424 | 0 | 0 | 11 | |
| GSE74703 | VEGFC | 7424 | 0 | 12 | 24 | |
| GSE74704 | VEGFC | 7424 | 0 | 5 | 15 | |
| TCGA | VEGFC | 7424 | 11 | 35 | 50 |
Total number of gains: 26; Total number of losses: 156; Total Number of normals: 306.
Somatic mutations of VEGFC:
Generating mutation plots.
Highly correlated genes for VEGFC:
Showing top 20/590 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VEGFC | S1PR1 | 0.760293 | 3 | 0 | 3 |
| VEGFC | MICAL1 | 0.713202 | 3 | 0 | 3 |
| VEGFC | RAPGEF6 | 0.702181 | 3 | 0 | 3 |
| VEGFC | TMX3 | 0.697264 | 3 | 0 | 3 |
| VEGFC | ITGBL1 | 0.693778 | 3 | 0 | 3 |
| VEGFC | NNMT | 0.663792 | 3 | 0 | 3 |
| VEGFC | TIE1 | 0.659502 | 6 | 0 | 5 |
| VEGFC | PXK | 0.656385 | 3 | 0 | 3 |
| VEGFC | ALDH1L2 | 0.653913 | 3 | 0 | 3 |
| VEGFC | NT5E | 0.653161 | 13 | 0 | 11 |
| VEGFC | APLNR | 0.645975 | 4 | 0 | 3 |
| VEGFC | GYPC | 0.645739 | 3 | 0 | 3 |
| VEGFC | CFH | 0.645263 | 6 | 0 | 5 |
| VEGFC | CHSY3 | 0.645027 | 7 | 0 | 6 |
| VEGFC | DPT | 0.64053 | 3 | 0 | 3 |
| VEGFC | LRRC8C | 0.639366 | 4 | 0 | 3 |
| VEGFC | FBLN5 | 0.638626 | 4 | 0 | 3 |
| VEGFC | ST6GALNAC5 | 0.6374 | 4 | 0 | 3 |
| VEGFC | RRP7A | 0.637123 | 4 | 0 | 3 |
| VEGFC | CLIP3 | 0.636201 | 3 | 0 | 3 |
For details and further investigation, click here
