RBBP8

 

Full name: RB binding protein 8, endonuclease Alias Symbol: CtIP|RIM|COM1
Type: protein-coding gene Cytoband: 18q11.2
Entrez ID: 5932 HGNC ID: HGNC:9891 Ensembl Gene: ENSG00000101773 OMIM ID: 604124
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of RBBP8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RBBP8 5932 203344_s_at 0.3331 0.5613
GSE20347 RBBP8 5932 203344_s_at 0.7080 0.0004
GSE23400 RBBP8 5932 203344_s_at 0.7628 0.0000
GSE26886 RBBP8 5932 203344_s_at 1.1290 0.0002
GSE29001 RBBP8 5932 203344_s_at 0.3751 0.2897
GSE38129 RBBP8 5932 203344_s_at 1.0482 0.0000
GSE45670 RBBP8 5932 203344_s_at 0.5356 0.0137
GSE53622 RBBP8 5932 119485 0.6049 0.0000
GSE53624 RBBP8 5932 119485 0.7348 0.0000
GSE63941 RBBP8 5932 203344_s_at 0.6488 0.2902
GSE77861 RBBP8 5932 203344_s_at 0.5488 0.2512
GSE97050 RBBP8 5932 A_33_P3240702 0.6797 0.1453
SRP007169 RBBP8 5932 RNAseq 1.9629 0.0000
SRP008496 RBBP8 5932 RNAseq 1.8569 0.0000
SRP064894 RBBP8 5932 RNAseq 0.2763 0.2450
SRP133303 RBBP8 5932 RNAseq 0.6729 0.0002
SRP159526 RBBP8 5932 RNAseq 0.8129 0.1060
SRP193095 RBBP8 5932 RNAseq 0.5731 0.0085
SRP219564 RBBP8 5932 RNAseq 0.0849 0.9038
TCGA RBBP8 5932 RNAseq 0.3112 0.0001

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by RBBP8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RBBP8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RBBP8 5932 3 6 21
GSE20123 RBBP8 5932 2 6 22
GSE43470 RBBP8 5932 4 1 38
GSE46452 RBBP8 5932 3 23 33
GSE47630 RBBP8 5932 7 17 16
GSE54993 RBBP8 5932 7 1 62
GSE54994 RBBP8 5932 4 12 37
GSE60625 RBBP8 5932 0 4 7
GSE74703 RBBP8 5932 3 1 32
GSE74704 RBBP8 5932 2 5 13
TCGA RBBP8 5932 15 24 57

Total number of gains: 50; Total number of losses: 100; Total Number of normals: 338.  

 

Somatic mutations of RBBP8:

 

Generating mutation plots.

 

Highly correlated genes for RBBP8:

 

Showing top 20/635 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RBBP8NOB10.67721504
RBBP8LARP60.658934404
RBBP8PCNA0.65546112011
RBBP8LRRC8D0.65398711011
RBBP8MCM40.6534251009
RBBP8DDHD20.65127303
RBBP8CDK10.6508461009
RBBP8CKS20.64302311010
RBBP8SNUPN0.640858403
RBBP8RFC40.63949511011
RBBP8MGME10.636594606
RBBP8NCAPG0.633681706
RBBP8SLC41A10.629361303
RBBP8CRLS10.624343604
RBBP8ETAA10.621519807
RBBP8PAICS0.6215011109
RBBP8CBX30.6211331109
RBBP8CENPF0.6186971109
RBBP8GINS10.6178211010
RBBP8MCM60.6117611109

For details and further investigation, click here