| Full name: leucine rich repeat containing 8 VRAC subunit D | Alias Symbol: FLJ10470 | ||
| Type: protein-coding gene | Cytoband: 1p22.2 | ||
| Entrez ID: 55144 | HGNC ID: HGNC:16992 | Ensembl Gene: ENSG00000171492 | OMIM ID: 612890 |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC8D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC8D | 55144 | 218684_at | 1.5687 | 0.0086 | |
| GSE20347 | LRRC8D | 55144 | 218684_at | 1.2440 | 0.0000 | |
| GSE23400 | LRRC8D | 55144 | 218684_at | 1.2198 | 0.0000 | |
| GSE26886 | LRRC8D | 55144 | 218684_at | 1.3031 | 0.0000 | |
| GSE29001 | LRRC8D | 55144 | 218684_at | 1.2723 | 0.0000 | |
| GSE38129 | LRRC8D | 55144 | 218684_at | 1.1632 | 0.0000 | |
| GSE45670 | LRRC8D | 55144 | 218684_at | 1.2303 | 0.0000 | |
| GSE53622 | LRRC8D | 55144 | 72304 | 1.5928 | 0.0000 | |
| GSE53624 | LRRC8D | 55144 | 72304 | 1.5373 | 0.0000 | |
| GSE63941 | LRRC8D | 55144 | 218684_at | 0.9437 | 0.1370 | |
| GSE77861 | LRRC8D | 55144 | 218684_at | 1.2307 | 0.0023 | |
| GSE97050 | LRRC8D | 55144 | A_23_P97365 | 0.7801 | 0.1509 | |
| SRP007169 | LRRC8D | 55144 | RNAseq | 2.8155 | 0.0000 | |
| SRP008496 | LRRC8D | 55144 | RNAseq | 2.6503 | 0.0000 | |
| SRP064894 | LRRC8D | 55144 | RNAseq | 1.1378 | 0.0000 | |
| SRP133303 | LRRC8D | 55144 | RNAseq | 1.2303 | 0.0000 | |
| SRP159526 | LRRC8D | 55144 | RNAseq | 1.3614 | 0.0000 | |
| SRP193095 | LRRC8D | 55144 | RNAseq | 1.2792 | 0.0000 | |
| SRP219564 | LRRC8D | 55144 | RNAseq | 1.2971 | 0.0035 | |
| TCGA | LRRC8D | 55144 | RNAseq | 0.3165 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by LRRC8D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC8D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC8D | 55144 | 0 | 8 | 22 | |
| GSE20123 | LRRC8D | 55144 | 0 | 8 | 22 | |
| GSE43470 | LRRC8D | 55144 | 2 | 5 | 36 | |
| GSE46452 | LRRC8D | 55144 | 1 | 1 | 57 | |
| GSE47630 | LRRC8D | 55144 | 8 | 5 | 27 | |
| GSE54993 | LRRC8D | 55144 | 0 | 1 | 69 | |
| GSE54994 | LRRC8D | 55144 | 6 | 2 | 45 | |
| GSE60625 | LRRC8D | 55144 | 0 | 0 | 11 | |
| GSE74703 | LRRC8D | 55144 | 1 | 4 | 31 | |
| GSE74704 | LRRC8D | 55144 | 0 | 5 | 15 | |
| TCGA | LRRC8D | 55144 | 6 | 22 | 68 |
Total number of gains: 24; Total number of losses: 61; Total Number of normals: 403.
Somatic mutations of LRRC8D:
Generating mutation plots.
Highly correlated genes for LRRC8D:
Showing top 20/1844 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC8D | CTHRC1 | 0.799637 | 7 | 0 | 7 |
| LRRC8D | CDCA5 | 0.791774 | 6 | 0 | 6 |
| LRRC8D | RFC4 | 0.784655 | 11 | 0 | 11 |
| LRRC8D | SNAP47 | 0.77507 | 3 | 0 | 3 |
| LRRC8D | WDR66 | 0.773206 | 7 | 0 | 7 |
| LRRC8D | KNSTRN | 0.772142 | 6 | 0 | 6 |
| LRRC8D | TXNDC12 | 0.771501 | 7 | 0 | 7 |
| LRRC8D | TTYH3 | 0.769774 | 7 | 0 | 7 |
| LRRC8D | BID | 0.76906 | 11 | 0 | 11 |
| LRRC8D | TRIP13 | 0.768824 | 11 | 0 | 11 |
| LRRC8D | CKAP2L | 0.761952 | 6 | 0 | 6 |
| LRRC8D | LAMC2 | 0.761374 | 11 | 0 | 11 |
| LRRC8D | IGF2BP2 | 0.760553 | 11 | 0 | 11 |
| LRRC8D | ATP1B3 | 0.757298 | 11 | 0 | 11 |
| LRRC8D | CKS1B | 0.757065 | 12 | 0 | 11 |
| LRRC8D | SNAI2 | 0.755363 | 8 | 0 | 8 |
| LRRC8D | FANCI | 0.751835 | 11 | 0 | 11 |
| LRRC8D | CEP55 | 0.751254 | 10 | 0 | 10 |
| LRRC8D | CBX3 | 0.749322 | 11 | 0 | 11 |
| LRRC8D | CDC25B | 0.749278 | 11 | 0 | 11 |
For details and further investigation, click here
