| Full name: mitochondrial genome maintenance exonuclease 1 | Alias Symbol: bA504H3.4|DDK1 | ||
| Type: protein-coding gene | Cytoband: 20p11.23 | ||
| Entrez ID: 92667 | HGNC ID: HGNC:16205 | Ensembl Gene: ENSG00000125871 | OMIM ID: 615076 |
| Drug and gene relationship at DGIdb | |||
Expression of MGME1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MGME1 | 92667 | 225890_at | 0.7841 | 0.0977 | |
| GSE26886 | MGME1 | 92667 | 225890_at | 0.5430 | 0.0277 | |
| GSE45670 | MGME1 | 92667 | 225890_at | 0.4925 | 0.0096 | |
| GSE53622 | MGME1 | 92667 | 2635 | 0.8333 | 0.0000 | |
| GSE53624 | MGME1 | 92667 | 2635 | 0.8991 | 0.0000 | |
| GSE63941 | MGME1 | 92667 | 225890_at | 1.1608 | 0.0104 | |
| GSE77861 | MGME1 | 92667 | 225890_at | 0.7857 | 0.0583 | |
| SRP007169 | MGME1 | 92667 | RNAseq | 0.9697 | 0.0120 | |
| SRP008496 | MGME1 | 92667 | RNAseq | 0.9896 | 0.0001 | |
| SRP064894 | MGME1 | 92667 | RNAseq | 0.9172 | 0.0002 | |
| SRP133303 | MGME1 | 92667 | RNAseq | 0.5335 | 0.0003 | |
| SRP159526 | MGME1 | 92667 | RNAseq | 1.1434 | 0.0000 | |
| SRP193095 | MGME1 | 92667 | RNAseq | 0.5245 | 0.0000 | |
| SRP219564 | MGME1 | 92667 | RNAseq | 0.6641 | 0.0502 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MGME1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of MGME1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MGME1 | 92667 | 12 | 3 | 15 | |
| GSE20123 | MGME1 | 92667 | 12 | 3 | 15 | |
| GSE43470 | MGME1 | 92667 | 11 | 1 | 31 | |
| GSE46452 | MGME1 | 92667 | 27 | 1 | 31 | |
| GSE47630 | MGME1 | 92667 | 17 | 4 | 19 | |
| GSE54993 | MGME1 | 92667 | 0 | 15 | 55 | |
| GSE54994 | MGME1 | 92667 | 25 | 2 | 26 | |
| GSE60625 | MGME1 | 92667 | 0 | 0 | 11 | |
| GSE74703 | MGME1 | 92667 | 8 | 1 | 27 | |
| GSE74704 | MGME1 | 92667 | 7 | 2 | 11 | |
| TCGA | MGME1 | 92667 | 43 | 10 | 43 |
Total number of gains: 162; Total number of losses: 42; Total Number of normals: 284.
Somatic mutations of MGME1:
Generating mutation plots.
Highly correlated genes for MGME1:
Showing top 20/790 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MGME1 | PCNA | 0.75642 | 6 | 0 | 6 |
| MGME1 | PTK7 | 0.753246 | 3 | 0 | 3 |
| MGME1 | GINS1 | 0.724889 | 7 | 0 | 6 |
| MGME1 | MCM8 | 0.710713 | 7 | 0 | 7 |
| MGME1 | RFC5 | 0.710562 | 3 | 0 | 3 |
| MGME1 | MFAP2 | 0.705607 | 3 | 0 | 3 |
| MGME1 | SNX5 | 0.699232 | 7 | 0 | 7 |
| MGME1 | NANP | 0.694654 | 3 | 0 | 3 |
| MGME1 | PRC1 | 0.689927 | 4 | 0 | 4 |
| MGME1 | SALL4 | 0.688425 | 3 | 0 | 3 |
| MGME1 | TOP2A | 0.684202 | 6 | 0 | 6 |
| MGME1 | CBX3 | 0.681051 | 6 | 0 | 6 |
| MGME1 | TCF3 | 0.679447 | 5 | 0 | 5 |
| MGME1 | SLX4IP | 0.679095 | 6 | 0 | 6 |
| MGME1 | CABYR | 0.677235 | 4 | 0 | 4 |
| MGME1 | APMAP | 0.674949 | 6 | 0 | 5 |
| MGME1 | UBE2C | 0.67481 | 6 | 0 | 5 |
| MGME1 | NEK2 | 0.674474 | 6 | 0 | 5 |
| MGME1 | POLR3F | 0.669734 | 6 | 0 | 6 |
| MGME1 | XRN2 | 0.669292 | 5 | 0 | 5 |
For details and further investigation, click here
