CKS2

 

Full name: CDC28 protein kinase regulatory subunit 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 9q22.2
Entrez ID: 1164 HGNC ID: HGNC:2000 Ensembl Gene: ENSG00000123975 OMIM ID: 116901
Drug and gene relationship at DGIdb
Screen Evidence:

 

CKS2 involved pathways:

KEGG pathway Description View
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

 

Expression of CKS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CKS2 1164 204170_s_at 0.6789 0.0886
GSE20347 CKS2 1164 204170_s_at 1.4809 0.0000
GSE23400 CKS2 1164 204170_s_at 2.1500 0.0000
GSE26886 CKS2 1164 204170_s_at 0.9228 0.0038
GSE29001 CKS2 1164 204170_s_at 1.4957 0.0003
GSE38129 CKS2 1164 204170_s_at 1.9461 0.0000
GSE45670 CKS2 1164 204170_s_at 1.5450 0.0000
GSE53622 CKS2 1164 6241 1.5929 0.0000
GSE53624 CKS2 1164 6241 1.8904 0.0000
GSE63941 CKS2 1164 204170_s_at 1.5103 0.0043
GSE77861 CKS2 1164 204170_s_at 0.7474 0.0316
GSE97050 CKS2 1164 A_23_P71727 1.2053 0.1709
SRP007169 CKS2 1164 RNAseq 2.1923 0.0001
SRP008496 CKS2 1164 RNAseq 1.6015 0.0000
SRP064894 CKS2 1164 RNAseq 1.8601 0.0000
SRP133303 CKS2 1164 RNAseq 1.5194 0.0000
SRP159526 CKS2 1164 RNAseq 1.0826 0.0012
SRP193095 CKS2 1164 RNAseq 0.6702 0.0021
SRP219564 CKS2 1164 RNAseq 1.1019 0.0640
TCGA CKS2 1164 RNAseq 0.9254 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by CKS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CKS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CKS2 1164 5 10 15
GSE20123 CKS2 1164 5 10 15
GSE43470 CKS2 1164 6 3 34
GSE46452 CKS2 1164 6 14 39
GSE47630 CKS2 1164 1 18 21
GSE54993 CKS2 1164 4 2 64
GSE54994 CKS2 1164 6 11 36
GSE60625 CKS2 1164 0 0 11
GSE74703 CKS2 1164 5 3 28
GSE74704 CKS2 1164 3 7 10
TCGA CKS2 1164 21 24 51

Total number of gains: 62; Total number of losses: 102; Total Number of normals: 324.  

 

Somatic mutations of CKS2:

 

Generating mutation plots.

 

Highly correlated genes for CKS2:

 

Showing top 20/1682 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CKS2CDK10.81443812012
CKS2TTK0.809111010
CKS2GINS10.80741111011
CKS2CENPF0.8034412012
CKS2GMNN0.79960412012
CKS2PRC10.79888812011
CKS2KIF4A0.79294812012
CKS2CDC60.791423909
CKS2UBE2T0.787464808
CKS2NUSAP10.78565412011
CKS2MCM60.78487812012
CKS2KNSTRN0.783386707
CKS2ASPM0.78289712011
CKS2RACGAP10.78248110010
CKS2MTFR20.782299707
CKS2UBE2C0.78107813012
CKS2FBXO50.78064312012
CKS2CDKN30.77969213012
CKS2BUB10.7771151009
CKS2TPX20.7770613012

For details and further investigation, click here