| Full name: chitinase acidic | Alias Symbol: AMCase|TSA1902|CHIT2 | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 27159 | HGNC ID: HGNC:17432 | Ensembl Gene: ENSG00000134216 | OMIM ID: 606080 |
| Drug and gene relationship at DGIdb | |||
Expression of CHIA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHIA | 27159 | 220630_s_at | -0.0740 | 0.7032 | |
| GSE20347 | CHIA | 27159 | 220630_s_at | -0.2563 | 0.0086 | |
| GSE23400 | CHIA | 27159 | 220630_s_at | -0.2737 | 0.0004 | |
| GSE26886 | CHIA | 27159 | 220630_s_at | -0.3351 | 0.0100 | |
| GSE29001 | CHIA | 27159 | 220630_s_at | -0.2624 | 0.0661 | |
| GSE38129 | CHIA | 27159 | 220630_s_at | -0.8364 | 0.0662 | |
| GSE45670 | CHIA | 27159 | 220630_s_at | -0.0655 | 0.6008 | |
| GSE53622 | CHIA | 27159 | 20733 | -0.3684 | 0.2952 | |
| GSE53624 | CHIA | 27159 | 20733 | -0.5716 | 0.0533 | |
| GSE63941 | CHIA | 27159 | 220630_s_at | -0.0041 | 0.9826 | |
| GSE77861 | CHIA | 27159 | 220630_s_at | -0.2423 | 0.2310 | |
| TCGA | CHIA | 27159 | RNAseq | -8.4877 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CHIA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHIA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHIA | 27159 | 0 | 11 | 19 | |
| GSE20123 | CHIA | 27159 | 0 | 11 | 19 | |
| GSE43470 | CHIA | 27159 | 0 | 8 | 35 | |
| GSE46452 | CHIA | 27159 | 2 | 1 | 56 | |
| GSE47630 | CHIA | 27159 | 9 | 5 | 26 | |
| GSE54993 | CHIA | 27159 | 0 | 1 | 69 | |
| GSE54994 | CHIA | 27159 | 7 | 4 | 42 | |
| GSE60625 | CHIA | 27159 | 0 | 0 | 11 | |
| GSE74703 | CHIA | 27159 | 0 | 7 | 29 | |
| GSE74704 | CHIA | 27159 | 0 | 7 | 13 | |
| TCGA | CHIA | 27159 | 7 | 27 | 62 |
Total number of gains: 25; Total number of losses: 82; Total Number of normals: 381.
Somatic mutations of CHIA:
Generating mutation plots.
Highly correlated genes for CHIA:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHIA | KCNE2 | 0.739772 | 5 | 0 | 5 |
| CHIA | TBC1D21 | 0.703412 | 3 | 0 | 3 |
| CHIA | CLDN18 | 0.699478 | 7 | 0 | 7 |
| CHIA | CPA2 | 0.68656 | 6 | 0 | 6 |
| CHIA | PGC | 0.682171 | 8 | 0 | 7 |
| CHIA | ATP4A | 0.681037 | 10 | 0 | 8 |
| CHIA | THRSP | 0.672483 | 3 | 0 | 3 |
| CHIA | PLD4 | 0.667951 | 3 | 0 | 3 |
| CHIA | HYAL3 | 0.65467 | 4 | 0 | 3 |
| CHIA | GKN1 | 0.65107 | 7 | 0 | 5 |
| CHIA | ATP4B | 0.644792 | 8 | 0 | 6 |
| CHIA | C6orf223 | 0.641496 | 3 | 0 | 3 |
| CHIA | REG1A | 0.640129 | 6 | 0 | 5 |
| CHIA | HHLA3 | 0.633305 | 3 | 0 | 3 |
| CHIA | TAAR2 | 0.630086 | 4 | 0 | 3 |
| CHIA | DCDC2B | 0.629792 | 3 | 0 | 3 |
| CHIA | PHGR1 | 0.629084 | 4 | 0 | 3 |
| CHIA | SPX | 0.623976 | 5 | 0 | 4 |
| CHIA | SMIM6 | 0.623375 | 5 | 0 | 3 |
| CHIA | FGG | 0.619397 | 5 | 0 | 3 |
For details and further investigation, click here
