| Full name: regulator of G protein signaling 20 | Alias Symbol: RGSZ1|ZGAP1 | ||
| Type: protein-coding gene | Cytoband: 8q11.23 | ||
| Entrez ID: 8601 | HGNC ID: HGNC:14600 | Ensembl Gene: ENSG00000147509 | OMIM ID: 607193 |
| Drug and gene relationship at DGIdb | |||
Expression of RGS20:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS20 | 8601 | 1569303_s_at | 0.4882 | 0.3507 | |
| GSE20347 | RGS20 | 8601 | 210138_at | 0.1534 | 0.7536 | |
| GSE23400 | RGS20 | 8601 | 210138_at | 0.2587 | 0.0030 | |
| GSE26886 | RGS20 | 8601 | 1569303_s_at | 0.7369 | 0.0043 | |
| GSE29001 | RGS20 | 8601 | 210138_at | -0.1163 | 0.8486 | |
| GSE38129 | RGS20 | 8601 | 210138_at | 0.5404 | 0.1183 | |
| GSE45670 | RGS20 | 8601 | 210138_at | 1.8825 | 0.0003 | |
| GSE53622 | RGS20 | 8601 | 44664 | 0.7676 | 0.0000 | |
| GSE53624 | RGS20 | 8601 | 44664 | 0.5512 | 0.0006 | |
| GSE63941 | RGS20 | 8601 | 210138_at | 0.0129 | 0.9885 | |
| GSE77861 | RGS20 | 8601 | 1569303_s_at | 0.0589 | 0.6786 | |
| GSE97050 | RGS20 | 8601 | A_23_P73097 | 0.1544 | 0.5574 | |
| SRP007169 | RGS20 | 8601 | RNAseq | 0.3668 | 0.4881 | |
| SRP008496 | RGS20 | 8601 | RNAseq | 0.6703 | 0.0705 | |
| SRP064894 | RGS20 | 8601 | RNAseq | 2.4464 | 0.0000 | |
| SRP133303 | RGS20 | 8601 | RNAseq | 1.2594 | 0.0000 | |
| SRP159526 | RGS20 | 8601 | RNAseq | 0.6867 | 0.3516 | |
| SRP219564 | RGS20 | 8601 | RNAseq | 2.0509 | 0.0287 | |
| TCGA | RGS20 | 8601 | RNAseq | 2.1094 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by RGS20 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS20:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS20 | 8601 | 14 | 2 | 14 | |
| GSE20123 | RGS20 | 8601 | 14 | 2 | 14 | |
| GSE43470 | RGS20 | 8601 | 14 | 3 | 26 | |
| GSE46452 | RGS20 | 8601 | 20 | 3 | 36 | |
| GSE47630 | RGS20 | 8601 | 23 | 1 | 16 | |
| GSE54993 | RGS20 | 8601 | 1 | 16 | 53 | |
| GSE54994 | RGS20 | 8601 | 28 | 0 | 25 | |
| GSE60625 | RGS20 | 8601 | 0 | 4 | 7 | |
| GSE74703 | RGS20 | 8601 | 13 | 2 | 21 | |
| GSE74704 | RGS20 | 8601 | 10 | 0 | 10 | |
| TCGA | RGS20 | 8601 | 43 | 10 | 43 |
Total number of gains: 180; Total number of losses: 43; Total Number of normals: 265.
Somatic mutations of RGS20:
Generating mutation plots.
Highly correlated genes for RGS20:
Showing top 20/312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS20 | BAIAP3 | 0.724018 | 3 | 0 | 3 |
| RGS20 | PIGW | 0.673298 | 3 | 0 | 3 |
| RGS20 | ZNF114 | 0.658525 | 3 | 0 | 3 |
| RGS20 | RABGEF1 | 0.649762 | 4 | 0 | 3 |
| RGS20 | IL36G | 0.648495 | 5 | 0 | 4 |
| RGS20 | SPATA2L | 0.64694 | 3 | 0 | 3 |
| RGS20 | TUSC3 | 0.64678 | 3 | 0 | 3 |
| RGS20 | RCC2 | 0.646217 | 3 | 0 | 3 |
| RGS20 | PPP1R14C | 0.641776 | 6 | 0 | 4 |
| RGS20 | IRX2 | 0.639608 | 3 | 0 | 3 |
| RGS20 | GLI1 | 0.63656 | 3 | 0 | 3 |
| RGS20 | QRFPR | 0.636291 | 3 | 0 | 3 |
| RGS20 | GINS4 | 0.636051 | 3 | 0 | 3 |
| RGS20 | S100A3 | 0.632145 | 9 | 0 | 6 |
| RGS20 | RUNX1-IT1 | 0.629447 | 3 | 0 | 3 |
| RGS20 | SPRY4 | 0.625722 | 4 | 0 | 3 |
| RGS20 | LINC00520 | 0.624172 | 5 | 0 | 4 |
| RGS20 | CEACAM19 | 0.620847 | 5 | 0 | 4 |
| RGS20 | PGP | 0.620646 | 3 | 0 | 3 |
| RGS20 | HMGA2 | 0.619208 | 4 | 0 | 3 |
For details and further investigation, click here
