| Full name: high mobility group AT-hook 2 | Alias Symbol: BABL|LIPO | ||
| Type: protein-coding gene | Cytoband: 12q14.3 | ||
| Entrez ID: 8091 | HGNC ID: HGNC:5009 | Ensembl Gene: ENSG00000149948 | OMIM ID: 600698 |
| Drug and gene relationship at DGIdb | |||
Expression of HMGA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGA2 | 8091 | 208025_s_at | 1.9719 | 0.2496 | |
| GSE20347 | HMGA2 | 8091 | 208025_s_at | 2.3149 | 0.0000 | |
| GSE23400 | HMGA2 | 8091 | 208025_s_at | 0.8695 | 0.0000 | |
| GSE26886 | HMGA2 | 8091 | 208025_s_at | 3.4556 | 0.0000 | |
| GSE29001 | HMGA2 | 8091 | 208025_s_at | 1.8741 | 0.0006 | |
| GSE38129 | HMGA2 | 8091 | 208025_s_at | 2.1862 | 0.0000 | |
| GSE45670 | HMGA2 | 8091 | 208025_s_at | 3.2829 | 0.0000 | |
| GSE53622 | HMGA2 | 8091 | 143646 | 0.3623 | 0.0000 | |
| GSE53624 | HMGA2 | 8091 | 143646 | 0.2120 | 0.0005 | |
| GSE63941 | HMGA2 | 8091 | 208025_s_at | 1.4957 | 0.2416 | |
| GSE77861 | HMGA2 | 8091 | 208025_s_at | 2.2300 | 0.0081 | |
| GSE97050 | HMGA2 | 8091 | A_33_P3211078 | 0.5151 | 0.2438 | |
| SRP007169 | HMGA2 | 8091 | RNAseq | 9.2585 | 0.0000 | |
| SRP008496 | HMGA2 | 8091 | RNAseq | 6.1086 | 0.0000 | |
| SRP133303 | HMGA2 | 8091 | RNAseq | 3.0799 | 0.0000 | |
| SRP159526 | HMGA2 | 8091 | RNAseq | 5.6387 | 0.0000 | |
| SRP219564 | HMGA2 | 8091 | RNAseq | 5.4142 | 0.0000 | |
| TCGA | HMGA2 | 8091 | RNAseq | 1.3228 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by HMGA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGA2 | 8091 | 5 | 1 | 24 | |
| GSE20123 | HMGA2 | 8091 | 5 | 1 | 24 | |
| GSE43470 | HMGA2 | 8091 | 5 | 0 | 38 | |
| GSE46452 | HMGA2 | 8091 | 13 | 0 | 46 | |
| GSE47630 | HMGA2 | 8091 | 10 | 1 | 29 | |
| GSE54993 | HMGA2 | 8091 | 0 | 7 | 63 | |
| GSE54994 | HMGA2 | 8091 | 6 | 1 | 46 | |
| GSE60625 | HMGA2 | 8091 | 0 | 0 | 11 | |
| GSE74703 | HMGA2 | 8091 | 5 | 0 | 31 | |
| GSE74704 | HMGA2 | 8091 | 4 | 1 | 15 | |
| TCGA | HMGA2 | 8091 | 23 | 9 | 64 |
Total number of gains: 76; Total number of losses: 21; Total Number of normals: 391.
Somatic mutations of HMGA2:
Generating mutation plots.
Highly correlated genes for HMGA2:
Showing top 20/1251 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGA2 | SPRED1 | 0.785434 | 3 | 0 | 3 |
| HMGA2 | KNSTRN | 0.785265 | 4 | 0 | 4 |
| HMGA2 | TENM2 | 0.763247 | 4 | 0 | 4 |
| HMGA2 | CDCA5 | 0.729365 | 4 | 0 | 4 |
| HMGA2 | SNAI2 | 0.722697 | 8 | 0 | 8 |
| HMGA2 | MMP1 | 0.721041 | 10 | 0 | 9 |
| HMGA2 | BUB1 | 0.720227 | 6 | 0 | 6 |
| HMGA2 | XPR1 | 0.711533 | 6 | 0 | 6 |
| HMGA2 | MPHOSPH6 | 0.708426 | 6 | 0 | 5 |
| HMGA2 | ORC6 | 0.70798 | 8 | 0 | 8 |
| HMGA2 | PTHLH | 0.705102 | 9 | 0 | 8 |
| HMGA2 | BLACAT1 | 0.704349 | 5 | 0 | 5 |
| HMGA2 | MASTL | 0.702232 | 4 | 0 | 4 |
| HMGA2 | TGFBI | 0.699682 | 10 | 0 | 10 |
| HMGA2 | FBRSL1 | 0.699093 | 5 | 0 | 5 |
| HMGA2 | SLC3A2 | 0.69819 | 7 | 0 | 7 |
| HMGA2 | NUDCD1 | 0.694149 | 4 | 0 | 4 |
| HMGA2 | TIPIN | 0.690684 | 7 | 0 | 7 |
| HMGA2 | MPLKIP | 0.689556 | 4 | 0 | 4 |
| HMGA2 | TRIP13 | 0.688535 | 9 | 0 | 8 |
For details and further investigation, click here
