| Full name: SH3 domain and tetratricopeptide repeats 1 | Alias Symbol: FLJ20356 | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 54436 | HGNC ID: HGNC:26009 | Ensembl Gene: ENSG00000125089 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of SH3TC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3TC1 | 54436 | 219256_s_at | 0.0283 | 0.9822 | |
| GSE20347 | SH3TC1 | 54436 | 219256_s_at | -0.7535 | 0.0025 | |
| GSE23400 | SH3TC1 | 54436 | 219256_s_at | -0.4311 | 0.0001 | |
| GSE26886 | SH3TC1 | 54436 | 219256_s_at | -0.7281 | 0.0730 | |
| GSE29001 | SH3TC1 | 54436 | 219256_s_at | -0.2204 | 0.5674 | |
| GSE38129 | SH3TC1 | 54436 | 219256_s_at | -0.3742 | 0.0925 | |
| GSE45670 | SH3TC1 | 54436 | 219256_s_at | 0.4934 | 0.1379 | |
| GSE53622 | SH3TC1 | 54436 | 95999 | 0.0151 | 0.9090 | |
| GSE53624 | SH3TC1 | 54436 | 95999 | -0.1977 | 0.0193 | |
| GSE63941 | SH3TC1 | 54436 | 229832_x_at | 0.1916 | 0.1585 | |
| GSE77861 | SH3TC1 | 54436 | 219256_s_at | 0.1007 | 0.8539 | |
| GSE97050 | SH3TC1 | 54436 | A_23_P41390 | 0.7223 | 0.1985 | |
| SRP007169 | SH3TC1 | 54436 | RNAseq | -1.0976 | 0.1008 | |
| SRP008496 | SH3TC1 | 54436 | RNAseq | -1.7401 | 0.0000 | |
| SRP064894 | SH3TC1 | 54436 | RNAseq | 0.3695 | 0.1891 | |
| SRP133303 | SH3TC1 | 54436 | RNAseq | -0.0655 | 0.8219 | |
| SRP159526 | SH3TC1 | 54436 | RNAseq | -0.1727 | 0.7477 | |
| SRP193095 | SH3TC1 | 54436 | RNAseq | -0.0314 | 0.8934 | |
| SRP219564 | SH3TC1 | 54436 | RNAseq | 0.7528 | 0.1701 | |
| TCGA | SH3TC1 | 54436 | RNAseq | -0.0977 | 0.4542 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SH3TC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3TC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3TC1 | 54436 | 0 | 18 | 12 | |
| GSE20123 | SH3TC1 | 54436 | 0 | 18 | 12 | |
| GSE43470 | SH3TC1 | 54436 | 0 | 17 | 26 | |
| GSE46452 | SH3TC1 | 54436 | 1 | 36 | 22 | |
| GSE47630 | SH3TC1 | 54436 | 1 | 19 | 20 | |
| GSE54993 | SH3TC1 | 54436 | 10 | 0 | 60 | |
| GSE54994 | SH3TC1 | 54436 | 3 | 12 | 38 | |
| GSE60625 | SH3TC1 | 54436 | 0 | 0 | 11 | |
| GSE74703 | SH3TC1 | 54436 | 0 | 13 | 23 | |
| GSE74704 | SH3TC1 | 54436 | 0 | 10 | 10 | |
| TCGA | SH3TC1 | 54436 | 8 | 47 | 41 |
Total number of gains: 23; Total number of losses: 190; Total Number of normals: 275.
Somatic mutations of SH3TC1:
Generating mutation plots.
Highly correlated genes for SH3TC1:
Showing top 20/64 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3TC1 | KRT6A | 0.656228 | 4 | 0 | 3 |
| SH3TC1 | MYO19 | 0.626781 | 3 | 0 | 3 |
| SH3TC1 | TBX10 | 0.617497 | 3 | 0 | 3 |
| SH3TC1 | RIN1 | 0.616262 | 5 | 0 | 4 |
| SH3TC1 | ADCK5 | 0.614076 | 3 | 0 | 3 |
| SH3TC1 | PPP1R14C | 0.612725 | 4 | 0 | 3 |
| SH3TC1 | PLCB3 | 0.612409 | 3 | 0 | 3 |
| SH3TC1 | RNF43 | 0.608109 | 4 | 0 | 3 |
| SH3TC1 | WDR55 | 0.600709 | 4 | 0 | 3 |
| SH3TC1 | ZDHHC12 | 0.600018 | 3 | 0 | 3 |
| SH3TC1 | VMO1 | 0.598869 | 3 | 0 | 3 |
| SH3TC1 | CYP2D6 | 0.593279 | 4 | 0 | 3 |
| SH3TC1 | ARSI | 0.592239 | 3 | 0 | 3 |
| SH3TC1 | KRT9 | 0.588367 | 4 | 0 | 3 |
| SH3TC1 | GM2A | 0.58246 | 4 | 0 | 3 |
| SH3TC1 | KLC3 | 0.578655 | 4 | 0 | 3 |
| SH3TC1 | ROS1 | 0.57677 | 3 | 0 | 3 |
| SH3TC1 | SDK2 | 0.575034 | 5 | 0 | 3 |
| SH3TC1 | PDZK1IP1 | 0.574627 | 7 | 0 | 6 |
| SH3TC1 | SSTR2 | 0.571724 | 4 | 0 | 3 |
For details and further investigation, click here
