| Full name: ring finger protein 8 | Alias Symbol: KIAA0646 | ||
| Type: protein-coding gene | Cytoband: 6p21.2 | ||
| Entrez ID: 9025 | HGNC ID: HGNC:10071 | Ensembl Gene: ENSG00000112130 | OMIM ID: 611685 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RNF8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNF8 | 9025 | 203160_s_at | 0.0963 | 0.8631 | |
| GSE20347 | RNF8 | 9025 | 203160_s_at | -0.2463 | 0.0092 | |
| GSE23400 | RNF8 | 9025 | 203160_s_at | -0.0491 | 0.4774 | |
| GSE26886 | RNF8 | 9025 | 203160_s_at | -0.4814 | 0.0066 | |
| GSE29001 | RNF8 | 9025 | 203160_s_at | -0.2173 | 0.4994 | |
| GSE38129 | RNF8 | 9025 | 203160_s_at | -0.0341 | 0.7987 | |
| GSE45670 | RNF8 | 9025 | 203160_s_at | -0.0270 | 0.8512 | |
| GSE53622 | RNF8 | 9025 | 108112 | -0.3109 | 0.0003 | |
| GSE53624 | RNF8 | 9025 | 108112 | -0.3256 | 0.0053 | |
| GSE63941 | RNF8 | 9025 | 203160_s_at | -0.1052 | 0.8117 | |
| GSE77861 | RNF8 | 9025 | 203160_s_at | -0.4865 | 0.0555 | |
| GSE97050 | RNF8 | 9025 | A_23_P70384 | -0.1240 | 0.6766 | |
| SRP007169 | RNF8 | 9025 | RNAseq | 0.1156 | 0.8224 | |
| SRP008496 | RNF8 | 9025 | RNAseq | 0.0685 | 0.8572 | |
| SRP064894 | RNF8 | 9025 | RNAseq | -0.3265 | 0.0221 | |
| SRP133303 | RNF8 | 9025 | RNAseq | -0.2551 | 0.0470 | |
| SRP159526 | RNF8 | 9025 | RNAseq | 0.0131 | 0.9516 | |
| SRP193095 | RNF8 | 9025 | RNAseq | -0.4423 | 0.0000 | |
| SRP219564 | RNF8 | 9025 | RNAseq | -0.2563 | 0.2733 | |
| TCGA | RNF8 | 9025 | RNAseq | 0.0899 | 0.1264 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RNF8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNF8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNF8 | 9025 | 6 | 0 | 24 | |
| GSE20123 | RNF8 | 9025 | 6 | 0 | 24 | |
| GSE43470 | RNF8 | 9025 | 6 | 1 | 36 | |
| GSE46452 | RNF8 | 9025 | 2 | 9 | 48 | |
| GSE47630 | RNF8 | 9025 | 8 | 4 | 28 | |
| GSE54993 | RNF8 | 9025 | 3 | 1 | 66 | |
| GSE54994 | RNF8 | 9025 | 10 | 5 | 38 | |
| GSE60625 | RNF8 | 9025 | 1 | 0 | 10 | |
| GSE74703 | RNF8 | 9025 | 6 | 0 | 30 | |
| GSE74704 | RNF8 | 9025 | 3 | 0 | 17 | |
| TCGA | RNF8 | 9025 | 16 | 14 | 66 |
Total number of gains: 67; Total number of losses: 34; Total Number of normals: 387.
Somatic mutations of RNF8:
Generating mutation plots.
Highly correlated genes for RNF8:
Showing top 20/697 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNF8 | ZKSCAN4 | 0.819493 | 3 | 0 | 3 |
| RNF8 | TMCO4 | 0.738927 | 3 | 0 | 3 |
| RNF8 | PIGM | 0.738082 | 3 | 0 | 3 |
| RNF8 | MMAA | 0.733984 | 3 | 0 | 3 |
| RNF8 | LRRC28 | 0.707292 | 4 | 0 | 4 |
| RNF8 | PUSL1 | 0.698179 | 4 | 0 | 4 |
| RNF8 | IFT46 | 0.69781 | 3 | 0 | 3 |
| RNF8 | INTS12 | 0.687497 | 3 | 0 | 3 |
| RNF8 | MKRN2 | 0.684546 | 3 | 0 | 3 |
| RNF8 | MOSPD2 | 0.678472 | 4 | 0 | 3 |
| RNF8 | FAM83D | 0.67364 | 3 | 0 | 3 |
| RNF8 | RPP38 | 0.671531 | 4 | 0 | 4 |
| RNF8 | C2orf76 | 0.671355 | 4 | 0 | 4 |
| RNF8 | CISD1 | 0.670963 | 3 | 0 | 3 |
| RNF8 | BLOC1S2 | 0.670721 | 3 | 0 | 3 |
| RNF8 | CAPNS2 | 0.66723 | 3 | 0 | 3 |
| RNF8 | STX18 | 0.663263 | 6 | 0 | 6 |
| RNF8 | TMEM120A | 0.660016 | 6 | 0 | 5 |
| RNF8 | ZCCHC9 | 0.652899 | 3 | 0 | 3 |
| RNF8 | DCTN5 | 0.652743 | 3 | 0 | 3 |
For details and further investigation, click here
