| Full name: ribosomal protein S6 kinase A1 | Alias Symbol: RSK1|HU-1|p90Rsk | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 6195 | HGNC ID: HGNC:10430 | Ensembl Gene: ENSG00000117676 | OMIM ID: 601684 |
| Drug and gene relationship at DGIdb | |||
RPS6KA1 involved pathways:
Expression of RPS6KA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6KA1 | 6195 | 203379_at | 1.2515 | 0.0331 | |
| GSE20347 | RPS6KA1 | 6195 | 203379_at | 0.5808 | 0.0008 | |
| GSE23400 | RPS6KA1 | 6195 | 203379_at | 0.4880 | 0.0000 | |
| GSE26886 | RPS6KA1 | 6195 | 203379_at | 1.1670 | 0.0000 | |
| GSE29001 | RPS6KA1 | 6195 | 203379_at | 0.1580 | 0.4091 | |
| GSE38129 | RPS6KA1 | 6195 | 203379_at | 0.8148 | 0.0000 | |
| GSE45670 | RPS6KA1 | 6195 | 203379_at | 0.8547 | 0.0001 | |
| GSE53622 | RPS6KA1 | 6195 | 63450 | 0.4768 | 0.0000 | |
| GSE53624 | RPS6KA1 | 6195 | 63450 | 0.5074 | 0.0000 | |
| GSE63941 | RPS6KA1 | 6195 | 203379_at | 2.4396 | 0.0002 | |
| GSE77861 | RPS6KA1 | 6195 | 203379_at | 0.4725 | 0.1676 | |
| GSE97050 | RPS6KA1 | 6195 | A_24_P396650 | 0.9073 | 0.1721 | |
| SRP007169 | RPS6KA1 | 6195 | RNAseq | 1.8945 | 0.0049 | |
| SRP008496 | RPS6KA1 | 6195 | RNAseq | 1.8871 | 0.0001 | |
| SRP064894 | RPS6KA1 | 6195 | RNAseq | 1.1044 | 0.0000 | |
| SRP133303 | RPS6KA1 | 6195 | RNAseq | 0.8371 | 0.0001 | |
| SRP159526 | RPS6KA1 | 6195 | RNAseq | 0.4475 | 0.2117 | |
| SRP193095 | RPS6KA1 | 6195 | RNAseq | 0.1199 | 0.6268 | |
| SRP219564 | RPS6KA1 | 6195 | RNAseq | 0.6610 | 0.2867 | |
| TCGA | RPS6KA1 | 6195 | RNAseq | 0.1127 | 0.1227 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by RPS6KA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6KA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS6KA1 | 6195 | 0 | 6 | 24 | |
| GSE20123 | RPS6KA1 | 6195 | 0 | 5 | 25 | |
| GSE43470 | RPS6KA1 | 6195 | 2 | 6 | 35 | |
| GSE46452 | RPS6KA1 | 6195 | 5 | 1 | 53 | |
| GSE47630 | RPS6KA1 | 6195 | 8 | 3 | 29 | |
| GSE54993 | RPS6KA1 | 6195 | 2 | 1 | 67 | |
| GSE54994 | RPS6KA1 | 6195 | 10 | 4 | 39 | |
| GSE60625 | RPS6KA1 | 6195 | 0 | 0 | 11 | |
| GSE74703 | RPS6KA1 | 6195 | 1 | 4 | 31 | |
| GSE74704 | RPS6KA1 | 6195 | 0 | 0 | 20 | |
| TCGA | RPS6KA1 | 6195 | 9 | 25 | 62 |
Total number of gains: 37; Total number of losses: 55; Total Number of normals: 396.
Somatic mutations of RPS6KA1:
Generating mutation plots.
Highly correlated genes for RPS6KA1:
Showing top 20/1015 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6KA1 | AGTRAP | 0.760269 | 5 | 0 | 5 |
| RPS6KA1 | CCT5 | 0.723691 | 7 | 0 | 7 |
| RPS6KA1 | TRIP13 | 0.722656 | 11 | 0 | 11 |
| RPS6KA1 | SERINC2 | 0.720881 | 3 | 0 | 3 |
| RPS6KA1 | FANCD2 | 0.714955 | 5 | 0 | 4 |
| RPS6KA1 | EME1 | 0.70868 | 6 | 0 | 6 |
| RPS6KA1 | PPP1R14C | 0.708385 | 6 | 0 | 6 |
| RPS6KA1 | OCIAD2 | 0.7046 | 8 | 0 | 8 |
| RPS6KA1 | SLC38A10 | 0.702398 | 3 | 0 | 3 |
| RPS6KA1 | STIL | 0.701401 | 10 | 0 | 9 |
| RPS6KA1 | BMP7 | 0.699809 | 3 | 0 | 3 |
| RPS6KA1 | POU5F2 | 0.698455 | 3 | 0 | 3 |
| RPS6KA1 | CDH3 | 0.694613 | 11 | 0 | 9 |
| RPS6KA1 | USP28 | 0.693857 | 3 | 0 | 3 |
| RPS6KA1 | LAMB3 | 0.693185 | 12 | 0 | 11 |
| RPS6KA1 | KIF2C | 0.691045 | 11 | 0 | 10 |
| RPS6KA1 | AGRN | 0.688256 | 12 | 0 | 12 |
| RPS6KA1 | WDR66 | 0.686245 | 8 | 0 | 8 |
| RPS6KA1 | CKAP2L | 0.685689 | 6 | 0 | 6 |
| RPS6KA1 | UBE2C | 0.684979 | 11 | 0 | 11 |
For details and further investigation, click here
