| Full name: regulator of telomere elongation helicase 1 | Alias Symbol: bK3184A7.3|NHL|DKFZP434C013|KIAA1088|RTEL | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 51750 | HGNC ID: HGNC:15888 | Ensembl Gene: ENSG00000258366 | OMIM ID: 608833 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RTEL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RTEL1 | 51750 | 213829_x_at | 0.1514 | 0.4462 | |
| GSE20347 | RTEL1 | 51750 | 213829_x_at | 0.0689 | 0.4628 | |
| GSE23400 | RTEL1 | 51750 | 213829_x_at | -0.0826 | 0.0385 | |
| GSE26886 | RTEL1 | 51750 | 213829_x_at | 0.5150 | 0.0000 | |
| GSE29001 | RTEL1 | 51750 | 213829_x_at | -0.0424 | 0.8280 | |
| GSE38129 | RTEL1 | 51750 | 213829_x_at | 0.0827 | 0.4009 | |
| GSE45670 | RTEL1 | 51750 | 213829_x_at | 0.1887 | 0.0490 | |
| GSE53622 | RTEL1 | 51750 | 80356 | 0.1583 | 0.0021 | |
| GSE53624 | RTEL1 | 51750 | 80356 | -0.0041 | 0.9568 | |
| GSE63941 | RTEL1 | 51750 | 213829_x_at | 0.1051 | 0.4010 | |
| GSE77861 | RTEL1 | 51750 | 213829_x_at | -0.0477 | 0.7598 | |
| GSE97050 | RTEL1 | 51750 | A_23_P378526 | 0.1683 | 0.4315 | |
| SRP007169 | RTEL1 | 51750 | RNAseq | 1.1460 | 0.0599 | |
| SRP064894 | RTEL1 | 51750 | RNAseq | 0.8803 | 0.0000 | |
| SRP133303 | RTEL1 | 51750 | RNAseq | 0.3271 | 0.0238 | |
| SRP159526 | RTEL1 | 51750 | RNAseq | 0.7965 | 0.1364 | |
| SRP193095 | RTEL1 | 51750 | RNAseq | 0.6929 | 0.0002 | |
| SRP219564 | RTEL1 | 51750 | RNAseq | 0.8613 | 0.0187 | |
| TCGA | RTEL1 | 51750 | RNAseq | 0.0133 | 0.8233 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RTEL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RTEL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RTEL1 | 51750 | 14 | 2 | 14 | |
| GSE20123 | RTEL1 | 51750 | 14 | 2 | 14 | |
| GSE43470 | RTEL1 | 51750 | 11 | 1 | 31 | |
| GSE46452 | RTEL1 | 51750 | 35 | 0 | 24 | |
| GSE47630 | RTEL1 | 51750 | 25 | 1 | 14 | |
| GSE54993 | RTEL1 | 51750 | 0 | 17 | 53 | |
| GSE54994 | RTEL1 | 51750 | 29 | 0 | 24 | |
| GSE60625 | RTEL1 | 51750 | 0 | 0 | 11 | |
| GSE74703 | RTEL1 | 51750 | 10 | 0 | 26 | |
| GSE74704 | RTEL1 | 51750 | 11 | 0 | 9 | |
| TCGA | RTEL1 | 51750 | 44 | 4 | 48 |
Total number of gains: 193; Total number of losses: 27; Total Number of normals: 268.
Somatic mutations of RTEL1:
Generating mutation plots.
Highly correlated genes for RTEL1:
Showing top 20/829 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RTEL1 | LONP1 | 0.773617 | 3 | 0 | 3 |
| RTEL1 | PPP1R13B | 0.741884 | 3 | 0 | 3 |
| RTEL1 | DRGX | 0.735847 | 3 | 0 | 3 |
| RTEL1 | SCARF2 | 0.724505 | 3 | 0 | 3 |
| RTEL1 | RHBDL1 | 0.711924 | 4 | 0 | 3 |
| RTEL1 | CDC42EP2 | 0.709252 | 5 | 0 | 4 |
| RTEL1 | ARVCF | 0.707217 | 8 | 0 | 7 |
| RTEL1 | ABCA4 | 0.706779 | 3 | 0 | 3 |
| RTEL1 | SP8 | 0.696718 | 4 | 0 | 3 |
| RTEL1 | RAI1 | 0.695485 | 6 | 0 | 6 |
| RTEL1 | COPS7B | 0.694372 | 3 | 0 | 3 |
| RTEL1 | CHRD | 0.693444 | 5 | 0 | 5 |
| RTEL1 | OR2T1 | 0.690583 | 3 | 0 | 3 |
| RTEL1 | ANKRD33 | 0.686788 | 3 | 0 | 3 |
| RTEL1 | LRFN3 | 0.684512 | 4 | 0 | 3 |
| RTEL1 | RP1L1 | 0.683923 | 3 | 0 | 3 |
| RTEL1 | RBP4 | 0.682068 | 3 | 0 | 3 |
| RTEL1 | ZNF221 | 0.680491 | 4 | 0 | 4 |
| RTEL1 | PSMB11 | 0.679402 | 4 | 0 | 4 |
| RTEL1 | NAT14 | 0.675213 | 4 | 0 | 3 |
For details and further investigation, click here
