HMCES

 

Full name: 5-hydroxymethylcytosine binding, ES cell specific Alias Symbol: DC12|SRAPD1
Type: protein-coding gene Cytoband: 3q21.3
Entrez ID: 56941 HGNC ID: HGNC:24446 Ensembl Gene: ENSG00000183624 OMIM ID: 618288
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of HMCES:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HMCES 56941 201678_s_at 0.4922 0.0339
GSE20347 HMCES 56941 201678_s_at 0.7166 0.0000
GSE23400 HMCES 56941 201678_s_at 0.5290 0.0000
GSE26886 HMCES 56941 201678_s_at 0.3427 0.0200
GSE29001 HMCES 56941 201678_s_at 0.6283 0.0341
GSE38129 HMCES 56941 201678_s_at 0.7275 0.0000
GSE45670 HMCES 56941 201678_s_at 0.4279 0.0083
GSE53622 HMCES 56941 98826 0.5716 0.0000
GSE53624 HMCES 56941 98826 0.5791 0.0000
GSE63941 HMCES 56941 201678_s_at 1.3998 0.0018
GSE77861 HMCES 56941 201678_s_at 0.6693 0.0142
SRP007169 HMCES 56941 RNAseq 1.3541 0.0002
SRP008496 HMCES 56941 RNAseq 1.0610 0.0002
SRP064894 HMCES 56941 RNAseq 0.6803 0.0125
SRP133303 HMCES 56941 RNAseq 0.3560 0.0897
SRP159526 HMCES 56941 RNAseq 0.7773 0.0137
SRP193095 HMCES 56941 RNAseq 0.6776 0.0000
SRP219564 HMCES 56941 RNAseq 0.1627 0.4173

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by HMCES expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of HMCES:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HMCES 56941 17 0 13
GSE20123 HMCES 56941 17 0 13
GSE43470 HMCES 56941 19 0 24
GSE46452 HMCES 56941 14 5 40
GSE47630 HMCES 56941 18 3 19
GSE54993 HMCES 56941 2 8 60
GSE54994 HMCES 56941 32 3 18
GSE60625 HMCES 56941 0 6 5
GSE74703 HMCES 56941 17 0 19
GSE74704 HMCES 56941 13 0 7

Total number of gains: 149; Total number of losses: 25; Total Number of normals: 218.  

 

Somatic mutations of HMCES:

 

Generating mutation plots.

 

Highly correlated genes for HMCES:

 

Showing top 20/1358 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HMCESMCM20.78829611011
HMCESRUVBL10.76341611010
HMCESPIK3R40.75691511010
HMCESTOPBP10.75684311011
HMCESNCBP20.753609707
HMCESUMPS0.74943310010
HMCESGMPS0.74557611011
HMCESRFC40.74340111010
HMCESMRPL380.733118303
HMCESLRRC580.732316404
HMCESGTF2E10.723742908
HMCESRPN10.723513909
HMCESRNASEH2A0.7214210010
HMCESABCF30.718454909
HMCESACTL6A0.71688311011
HMCESCKS1B0.71649310010
HMCESRNF70.715861008
HMCESTBL1XR10.709743909
HMCESPOLR2H0.70720211010
HMCESTPX20.70688510010

For details and further investigation, click here