| Full name: salvador family WW domain containing protein 1 | Alias Symbol: WW45|WWP4|salvador | ||
| Type: protein-coding gene | Cytoband: 14q22.1 | ||
| Entrez ID: 60485 | HGNC ID: HGNC:17795 | Ensembl Gene: ENSG00000151748 | OMIM ID: 607203 |
| Drug and gene relationship at DGIdb | |||
SAV1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of SAV1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SAV1 | 60485 | 234491_s_at | 0.1460 | 0.8683 | |
| GSE20347 | SAV1 | 60485 | 218276_s_at | 0.9556 | 0.0003 | |
| GSE23400 | SAV1 | 60485 | 218276_s_at | 0.8209 | 0.0000 | |
| GSE26886 | SAV1 | 60485 | 222573_s_at | 0.3027 | 0.1362 | |
| GSE29001 | SAV1 | 60485 | 218276_s_at | 1.3485 | 0.0005 | |
| GSE38129 | SAV1 | 60485 | 218276_s_at | 0.6568 | 0.0020 | |
| GSE45670 | SAV1 | 60485 | 234491_s_at | 0.1072 | 0.6756 | |
| GSE53622 | SAV1 | 60485 | 65628 | 0.2907 | 0.0071 | |
| GSE53624 | SAV1 | 60485 | 65628 | 0.5985 | 0.0000 | |
| GSE63941 | SAV1 | 60485 | 222573_s_at | 0.1209 | 0.8087 | |
| GSE77861 | SAV1 | 60485 | 218276_s_at | 1.0218 | 0.0394 | |
| GSE97050 | SAV1 | 60485 | A_24_P287473 | -0.0342 | 0.9774 | |
| SRP007169 | SAV1 | 60485 | RNAseq | 1.4453 | 0.0004 | |
| SRP008496 | SAV1 | 60485 | RNAseq | 1.3837 | 0.0000 | |
| SRP064894 | SAV1 | 60485 | RNAseq | 0.4568 | 0.0090 | |
| SRP133303 | SAV1 | 60485 | RNAseq | 0.3399 | 0.0872 | |
| SRP159526 | SAV1 | 60485 | RNAseq | 0.5633 | 0.1400 | |
| SRP193095 | SAV1 | 60485 | RNAseq | 0.8489 | 0.0000 | |
| SRP219564 | SAV1 | 60485 | RNAseq | 0.5304 | 0.1392 | |
| TCGA | SAV1 | 60485 | RNAseq | -0.0285 | 0.6111 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SAV1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SAV1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SAV1 | 60485 | 8 | 2 | 20 | |
| GSE20123 | SAV1 | 60485 | 8 | 3 | 19 | |
| GSE43470 | SAV1 | 60485 | 9 | 1 | 33 | |
| GSE46452 | SAV1 | 60485 | 16 | 3 | 40 | |
| GSE47630 | SAV1 | 60485 | 11 | 10 | 19 | |
| GSE54993 | SAV1 | 60485 | 3 | 9 | 58 | |
| GSE54994 | SAV1 | 60485 | 20 | 4 | 29 | |
| GSE60625 | SAV1 | 60485 | 0 | 2 | 9 | |
| GSE74703 | SAV1 | 60485 | 8 | 1 | 27 | |
| GSE74704 | SAV1 | 60485 | 3 | 2 | 15 | |
| TCGA | SAV1 | 60485 | 34 | 13 | 49 |
Total number of gains: 120; Total number of losses: 50; Total Number of normals: 318.
Somatic mutations of SAV1:
Generating mutation plots.
Highly correlated genes for SAV1:
Showing top 20/199 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SAV1 | POLE4 | 0.74055 | 3 | 0 | 3 |
| SAV1 | CHSY1 | 0.657147 | 8 | 0 | 6 |
| SAV1 | ARHGAP22 | 0.654299 | 3 | 0 | 3 |
| SAV1 | CA6 | 0.653087 | 3 | 0 | 3 |
| SAV1 | BUB1B | 0.648859 | 5 | 0 | 5 |
| SAV1 | MKI67 | 0.647842 | 4 | 0 | 4 |
| SAV1 | PDGFA | 0.647171 | 8 | 0 | 7 |
| SAV1 | L3HYPDH | 0.642458 | 5 | 0 | 4 |
| SAV1 | COL4A2 | 0.635318 | 8 | 0 | 7 |
| SAV1 | ZNF697 | 0.634844 | 4 | 0 | 3 |
| SAV1 | LBH | 0.633494 | 9 | 0 | 7 |
| SAV1 | VCAN | 0.633169 | 9 | 0 | 7 |
| SAV1 | TUBB | 0.630954 | 6 | 0 | 5 |
| SAV1 | FNDC3B | 0.630231 | 9 | 0 | 8 |
| SAV1 | ICE1 | 0.623411 | 9 | 0 | 7 |
| SAV1 | NUP62CL | 0.618381 | 4 | 0 | 3 |
| SAV1 | SH3BP4 | 0.613122 | 9 | 0 | 7 |
| SAV1 | C11orf95 | 0.601614 | 7 | 0 | 6 |
| SAV1 | TP53BP1 | 0.60079 | 7 | 0 | 6 |
| SAV1 | ENPEP | 0.600326 | 6 | 0 | 5 |
For details and further investigation, click here
